Imperial College London
Alternate

DrVasaCurcin

Faculty of Medicine, School of Public Health

Honorary Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 0716vasa.curcin Website

 
 
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Location

 

320Reynolds BuildingCharing Cross Campus

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Summary

 

Publications

Citation

BibTex format

@article{Snell:2021:10.1101/2021.03.16.21253377,
author = {Snell, LB and Wang, W and Alcolea-Medina, A and Charalampous, T and Nebbia, G and Batra, R and de, Jongh L and Higgins, F and Wang, Y and Edgeworth, JD and Curcin, V},
doi = {10.1101/2021.03.16.21253377},
title = {First and second SARS-CoV-2 waves in inner London: A comparison of admission characteristics and the impact of the B.1.1.7 variant},
url = {http://dx.doi.org/10.1101/2021.03.16.21253377},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - <jats:title>Abstract</jats:title><jats:sec><jats:title>Introduction</jats:title><jats:p>A second wave of SARS-CoV-2 infection spread across the UK in 2020 linked with emergence of the more transmissible B.1.1.7 variant. The emergence of new variants, particularly during relaxation of social distancing policies and implementation of mass vaccination, highlights the need for real-time integration of detailed patient clinical data alongside pathogen genomic data. We linked clinical data with viral genome sequence data to compare cases admitted during the first and second waves of SARS-CoV-2 infection.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Clinical, laboratory and demographic data from five electronic health record (EHR) systems was collected for all cases with a positive SARS-CoV-2 RNA test between March 13th 2020 and February 17th 2021. SARS-CoV-2 viral sequencing was performed using Oxford Nanopore Technology. Descriptive data are presented comparing cases between waves, and between cases of B.1.1.7 and non-B.1.1.7 variants.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>There were 5810 SARS-CoV-2 RNA positive cases comprising inpatients (n=2341), healthcare workers (n=1549), outpatients (n=874), emergency department (ED) attenders not subsequently admitted (n=532), inter-hospital transfers (n=281) and nosocomial cases (n=233). There were two dominant waves of hospital admissions, with wave one starting from March 13<jats:sup>th</jats:sup>(n=838) and wave two from October 20<jats:sup>th</jats:sup>(n=1503), both with a temporally aligned rise in nosocomial cases (n=96 in wave one, n=137 in wave two). 1470 SARS-CoV-2 isolates were successfully sequenced, including 216/838 (26%) admitted cases from wave one, 472/1503 (31%) admitted cases in wave two and 121/233 (52%) nosocomial cases. The
AU  - Snell,LB
AU  - Wang,W
AU  - Alcolea-Medina,A
AU  - Charalampous,T
AU  - Nebbia,G
AU  - Batra,R
AU  - de,Jongh L
AU  - Higgins,F
AU  - Wang,Y
AU  - Edgeworth,JD
AU  - Curcin,V
DO  - 10.1101/2021.03.16.21253377
PY  - 2021///
TI  - First and second SARS-CoV-2 waves in inner London: A comparison of admission characteristics and the impact of the B.1.1.7 variant
UR  - http://dx.doi.org/10.1101/2021.03.16.21253377
ER  -
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