Imperial College London
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Professor Vasso Episkopou

Faculty of Medicine, Department of Brain Sciences

Emeritus Professor
 
 
 
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Contact

 

+44 (0)20 7594 6587vasso.episkopou

 
 
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Location

 

Burlington DanesHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Bravou:2009:10.3233/CLO-2009-0460,
author = {Bravou, V and Antonacopoulou, A and Papadaki, H and Floratou, K and Stavropoulos, M and Episkopou, V and Petropoulou, C and Kalofonos, H},
doi = {10.3233/CLO-2009-0460},
journal = {Cellular Oncology},
pages = {41--51},
title = {TGF-beta repressors SnoN and Ski are implicated in human colorectal carcinogenesis},
url = {http://dx.doi.org/10.3233/CLO-2009-0460},
volume = {31},
year = {2009}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background: The TGF-β signaling repressors SnoN and Ski have been critically implicated in human cancer.Methods: To explore the role of SnoN and Ski in the development and progression of colorectal cancer we examined their protein expression profile by immunohistochemistry in a series of human colorectal adenomas, carcinomas and lymph node metastases. The mRNA expression of SnoN was also quantified by Real-Time RT-PCR.Results: SnoN and Ski were overexpressed both in adenomas with severe dysplasia and colorectal carcinomas. Protein expression was cytoplasmic and nuclear with predominant cytoplasmic localization. The subcellular localization was related differently to pathologic variables of colorectal carcinomas. Although there was no significant association of protein levels with tumor invasion and metastasis, a significant correlation of nuclear SnoN and Ski with β-catenin pathway was observed. Moreover, SnoN mRNA did not differ in carcinomas as compared to normal control and there was no correlation between SnoN protein and mRNA levels.Conclusion: Our findings suggest that SnoN and Ski exert oncogenic effects in human colorectal carcinogenesis and their overexpression is implicated in early stage disease.
AU  - Bravou,V
AU  - Antonacopoulou,A
AU  - Papadaki,H
AU  - Floratou,K
AU  - Stavropoulos,M
AU  - Episkopou,V
AU  - Petropoulou,C
AU  - Kalofonos,H
DO  - 10.3233/CLO-2009-0460
EP  - 51
PY  - 2009///
SN  - 0884-6812
SP  - 41
TI  - TGF-beta repressors SnoN and Ski are implicated in human colorectal carcinogenesis
T2  - Cellular Oncology
UR  - http://dx.doi.org/10.3233/CLO-2009-0460
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000264610400005&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.hindawi.com/journals/acp/2009/975602/
UR  - http://hdl.handle.net/10044/1/95742
VL  - 31
ER  -
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