Imperial College London
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Professor Vasso Episkopou

Faculty of Medicine, Department of Brain Sciences

Emeritus Professor
 
 
 
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Contact

 

+44 (0)20 7594 6587vasso.episkopou

 
 
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Location

 

Burlington DanesHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Kicheva:2014:10.1126/science.1254927,
author = {Kicheva, A and Bollenbach, T and Ribeiro, A and Valle, HP and Lovell-Badge, R and Episkopou, V and Briscoe, J},
doi = {10.1126/science.1254927},
journal = {Science},
pages = {1--11},
title = {Coordination of progenitor specification and growth in mouse and chick spinal cord},
url = {http://dx.doi.org/10.1126/science.1254927},
volume = {345},
year = {2014}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Development requires tissue growth as well as cell diversification. To address how these processes are coordinated, we analyzed the development of molecularly distinct domains of neural progenitors in the mouse and chick neural tube. We show that during development, these domains undergo changes in size that do not scale with changes in overall tissue size. Our data show that domain proportions are first established by opposing morphogen gradients and subsequently controlled by domain-specific regulation of differentiation rate but not differences in proliferation rate. Regulation of differentiation rate is key to maintaining domain proportions while accommodating both intra- and interspecies variations in size. Thus, the sequential control of progenitor specification and differentiation elaborates pattern without requiring that signaling gradients grow as tissues expand.
AU  - Kicheva,A
AU  - Bollenbach,T
AU  - Ribeiro,A
AU  - Valle,HP
AU  - Lovell-Badge,R
AU  - Episkopou,V
AU  - Briscoe,J
DO  - 10.1126/science.1254927
EP  - 11
PY  - 2014///
SN  - 0036-8075
SP  - 1
TI  - Coordination of progenitor specification and growth in mouse and chick spinal cord
T2  - Science
UR  - http://dx.doi.org/10.1126/science.1254927
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000342164500032&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://science.sciencemag.org/content/345/6204/1254927
VL  - 345
ER  -
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