Imperial College London

DrVanessaGarcia Larsen

Faculty of MedicineNational Heart & Lung Institute

Honorary Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 7945vgla

 
 
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Location

 

61Emmanuel Kaye BuildingRoyal Brompton Campus

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Summary

 

Publications

Publication Type
Year
to

135 results found

Poudyal A, Karki KB, Shrestha N, Aryal KK, Mahato NK, Bista B, Ghimire L, Kc D, Gyanwali P, Jha AK, Garcia-Larsen V, Kuch U, Groneberg DA, Sharma SK, Dhimal Met al., 2022, Prevalence and risk factors associated with chronic kidney disease in Nepal: evidence from a nationally representative population-based cross-sectional study., BMJ Open, Vol: 12, Pages: e057509-e057509, ISSN: 2044-6055

OBJECTIVE: This study aimed to determine population-based prevalence of chronic kidney disease (CKD) and its associated factors in Nepal. STUDY DESIGN: The study was a nationwide population-based cross-sectional study. SETTING AND PARTICIPANTS: Cross-sectional survey conducted in a nationally representative sample of 12 109 Nepalese adult from 2016 to 2018 on selected chronic non-communicable diseases was examined. Multistage cluster sampling with a mix of probability proportionate to size and systematic random sampling was used for the selection of individuals aged 20 years and above. PRIMARY AND SECONDARY OUTCOME MEASURES: Primary outcome in this study was population-based prevalence of CKD in Nepal. A participant was considered to have CKD if the urine albumin-to-creatinine ratio was greater than or equal to 30 mg/g and/or estimated glomerular filtration rate is less than 60 mL/min/1.73 m2 at baseline and in follow-up using modification of diet in renal disease study equations. The secondary outcome measure was factors associated with CKD in Nepal. The covariate adjusted association of risk factors and CKD was calculated using multivariable binary logistic regression. RESULTS: The overall prevalence of CKD in Nepal was 6.0% (95% CI 5.5 to 6.6). Factors independently associated with CKD included older age (adjusted OR (AOR) 2.6, 95% CI 1.9 to 3.6), Dalit caste (AOR 1.6, 95% CI 1.1 to 2.3), hypertension (AOR 2.4, 95% CI 2.0 to 3.0), diabetes mellitus (AOR 3.2, 95% CI 2.5 to 4.1), raised total cholesterol (AOR 1.3, 95% CI 1.0 to 1.6) and increased waist-to-hip ratio (AOR 1.6, 95% CI 1.2 to 2.3). CONCLUSION: This nationally representative study shows that the prevalence of CKD in the adult population of Nepal is substantial, and it is independently associated with several cardiometabolic traits. These findings warrant longitudinal studies to identify the causes of CKD in Nepal and effective strategies to

Journal article

Hernandes VV, Dordevic N, Hantikainen EM, Sigurdsson BB, Smarason SV, Garcia-Larsen V, Gogele M, Caprioli G, Bozzolan I, Pramstaller PP, Rainer Jet al., 2022, Age, Sex, Body Mass Index, Diet and Menopause Related Metabolites in a Large Homogeneous Alpine Cohort, METABOLITES, Vol: 12

Journal article

Guzman-Vilca WC, Yovera Juarez EA, Tarazona-Meza C, Garcia-Larsen V, Carrillo Larco Ret al., 2022, Sugar-sweetened beverages consumption in adults: evidence from a National Health Survey in Peru, Nutrients, Vol: 14, ISSN: 2072-6643

High consumption of sugar-sweetened beverages (SSB) is associated with a high risk of non-communicable diseases. Evidence of SSB consumption is needed to inform SSB-related policies, especially in countries with a high consumption, such as Peru. Using data from Peru’s National Health Survey conducted in 2017–2018, the consumption of homemade and ready-to-drink SSB was estimated from a single 24 h dietary recall, accounting for socio-demographic and health-related variables. Regression models were fitted to assess which variables were linked to a high/low SSB consumption. There were 913 people and mean age was 37.7 years (95% confidence interval (CI): 36.9–38.6). Mean consumption (8 oz servings/day) of homemade SSB (1.2) doubled that of ready-to-drink SSB (0.5). The intake of homemade and ready-to-drink SSB was higher in men (1.3 and 0.7) than women (1.1 and 0.3). The intake of ready-to-drink SSB was higher in urban (0.6) compared to rural (0.2) populations. People aware of having diabetes had a lower consumption of both ready-to-drink (0.9 vs. 0.4) and homemade SSB (1.3 vs. 0.8) than those unaware of having diabetes. Male sex and living in urban locations were associated with higher ready-to-drink SSB intake. Older age was associated with a higher intake of homemade SSB. Amongst Peruvian adults, the consumption of SSB products (particularly homemade) remains high. Population-wide interventions should also aim to improve awareness of the nutritional components of homemade beverages.

Journal article

Paudyal N, Parajuli KR, Garcia Larsen V, Adhikari RK, Devkota MD, Rijal S, Chitekwe S, Torlesse Het al., 2022, A review of the maternal iron and folic acid supplementation programme in Nepal: Achievements and challenges, Maternal and Child Nutrition, Vol: 18, ISSN: 1740-8695

In the late 1990s, an estimated 75% of pregnant women in Nepal were anaemic. Although iron and folic acid (IFA) supplements were available free of charge, coverage among pregnant women was very low. In response, the Government of Nepal launched the Iron Intensification Programme (IIP) in 2003 to improve the coverage of IFA supplementation and anthelminthic treatment during pregnancy, as well as promote the utilization of antenatal care. This review examined how the IIP programme contributed to Nepal's success in increasing the consumption of IFA supplements during pregnancy. Nepal's cadre of Female Community Health Volunteers were engaged in the IIP to support the community-based distribution of IFA supplements to pregnant women and complement IFA distribution through health facilities and outreach services. As a result, the country achieved a fourfold increase in the proportion of women who took IFA supplements during pregnancy between 2001 and 2016 (from 23% to 91%) and a 12-fold increase in the proportion who took IFA supplements for at least 90 days during pregnancy (from 6% to 71%). The increase in coverage of IFA supplements accompanied an increase in the coverage of antenatal care during the same period. By 2016, the prevalence of anaemia in pregnant women decreased to 46%, highlighting the need to tackle other causes of anaemia and improve haemoglobin concentration before pregnancy, while maintaining the successful efforts to reach pregnant women with IFA supplements at the community level.

Journal article

Ducharme-Smith K, Brady TM, Vizthum D, Caulfield LE, Mueller NT, Rosenstock S, Garcia-Larsen Vet al., 2021, Diet quality scores associated with improved cardiometabolic measures among African American adolescents, PEDIATRIC RESEARCH, ISSN: 0031-3998

Journal article

Bernier-Jean A, Wong G, Saglimbene V, Ruospo M, Palmer SC, Natale P, Garcia-Larsen V, Johnson DW, Tonelli M, Hegbrant J, Craig JC, Teixeira-Pinto A, Strippoli GFMet al., 2021, Dietary potassium intake and all-cause mortality in adults treated with hemodialysis, Clinical Journal of the American Society of Nephrology, Vol: 16, Pages: 1851-1861, ISSN: 1555-9041

Background and objectives Dietary potassium restriction in people receiving maintenance hemodialysis is standard practice and is recommended in guidelines, despite a lack of evidence. We aimed to assess the association between dietary potassium intake and mortality and whether hyperkalemia mediates this association.Design, setting, participants, & measurements A total of 8043 adults undergoing maintenance hemodialysis in Europe and South America were included in the DIETary intake, death and hospitalization in adults with end-stage kidney disease treated with HemoDialysis (DIET-HD) study. We measured baseline potassium intake from the Global Allergy and Asthma European Network food frequency questionnaire and performed time-to-event and mediation analyses.Results The median potassium intake at baseline was 3.5 (interquartile range, 2.5–5.0) g/d. During a median follow-up of 4.0 years (25,890 person-years), we observed 2921 (36%) deaths. After adjusting for baseline characteristics, including cardiac disease and food groups, dietary potassium intake was not associated with all-cause mortality (per 1 g/d higher dietary potassium intake: hazard ratio, 1.00; 95% confidence interval [95% CI], 0.95 to 1.05). A mediation analysis showed no association of potassium intake with mortality, either through or independent of serum potassium (hazard ratio, 1.00; 95% CI, 1.00 to 1.00 and hazard ratio, 1.01; 95% CI, 0.96 to 1.06, respectively). Potassium intake was not significantly associated with serum levels (0.03; 95% CI, −0.01 to 0.07 mEq/L per 1 g/d higher dietary potassium intake) or the prevalence of hyperkalemia (≥6.0 mEq/L) at baseline (odds ratio, 1.11; 95% CI, 0.89 to 1.37 per 1 g/d higher dietary potassium intake). Hyperkalemia was associated with cardiovascular death (hazard ratio, 1.23; 95% CI, 1.03 to 1.48).Conclusions Higher dietary intake of potassium is not associated with hyperkalemia or death in patients treated with hemodialysis.

Journal article

Bernier-Jean A, Wong G, Saglimbene V, Ruospo M, Palmer SC, Natale P, Garcia-Larsen V, Johnson DW, Tonelli M, Hegbrant J, Craig JC, Teixeira-Pinto A, Strippoli GFMet al., 2021, Self-Reported Physical Activity and Survival in Adults Treated With Hemodialysis: A DIET-HD Cohort Study, KIDNEY INTERNATIONAL REPORTS, Vol: 6, Pages: 3014-3025, ISSN: 2468-0249

Journal article

Helfer B, Leonardi-Bee J, Mundell A, Parr C, Ierodiakonou D, Garcia-Larsen V, Kroeger CM, Dai Z, Man A, Jobson J, Dewji F, Kunc M, Bero L, Boyle RJet al., 2021, Conduct and reporting of formula milk trials: systematic review (vol 375, n2202, 2021), BMJ: British Medical Journal, Vol: 375, Pages: 1-1, ISSN: 0959-535X

Journal article

Helfer B, Leonardi-Bee J, Mundell A, Parr C, Ierodiakonou D, Garcia-Larsen V, Kroeger CM, Dai Z, Man A, Jobson J, Dewji F, Kunc M, Bero L, Boyle Ret al., 2021, Conduct and reporting of formula milk trials: systematic review, BMJ: British Medical Journal, Vol: 375, Pages: 1-9, ISSN: 0959-535X

Objective To systematically review the conduct and reporting of formula trials.Design Systematic review.Data sources Medline, Embase, and Cochrane Central Register of Controlled Trials (CENTRAL) were searched from 1 January 2006 to 31 December 2020.Review methods Intervention trials comparing at least two formula products in children less than three years of age were included, but not trials of human breast milk or fortifiers of breast milk. Data were extracted in duplicate and primary outcome data were synthesised for meta-analysis with a random effects model weighted by the inverse variance method. Risk of bias was evaluated with Cochrane risk of bias version 2.0, and risk of undermining breastfeeding was evaluated according to published consensus guidance. Primary outcomes of the trials included in the systematic review were identified from clinical trial registries, protocols, or trial publications.Results 22 201 titles were screened and 307 trials were identified that were published between 2006 and 2020, of which 73 (24%) trials in 13 197 children were prospectively registered. Another 111 unpublished but registered trials in 17 411 children were identified. Detailed analysis was undertaken for 125 trials (23 757 children) published since 2015. Seventeen (14%) of these recently published trials were conducted independently of formula companies, 26 (21%) were prospectively registered with a clear aim and primary outcome, and authors or sponsors shared prospective protocols for 11 (9%) trials. Risk of bias was low in five (4%) and high in 100 (80%) recently published trials, mainly because of inappropriate exclusions from analysis and selective reporting. For 68 recently published superiority trials, a pooled standardised mean difference of 0.51 (range −0.43 to 3.29) was calculated with an asymmetrical funnel plot (Egger’s test P<0.001), which reduced to 0.19 after correction for asymmetry. Primary outcomes were reporte

Journal article

Ducharme-Smith K, Mora-Garcia G, Mendes FDC, Stephany Ruiz-Diaz M, Moreira A, Villegas R, Garcia-Larsen Vet al., 2021, Lung function, COPD and alternative healthy eating index in US adults, ERJ Open Research, Vol: 7, Pages: 1-12, ISSN: 2312-0541

Background There is a large burden of COPD in the US. The purpose of this study was to investigate the association between diet quality with lung function, spirometric restriction and spirometrically defined COPD in a nationally representative sample of US adults.Methods Adults (19–70 years of age) from the National Health and Nutrition Examination Survey 2007–2012 cycles were included (n=10 428). Diet quality was determined using the Alternative Healthy Eating Index (AHEI-2010). Pre-bronchodilator measurements of forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and the FEV1/FVC were described. Calibrated lower limit of normal (LLN) estimates were derived to determine prevalence of spirometric restriction (FVC<LLN) and COPD (FEV1/FVC ratio<LLN). Population-weighted linear and logistic regression models were used to investigate the association of AHEI-2010 and respiratory outcomes.Results The mean±SD AHEI was 45.3±12.2, equivalent to meeting 41% of the daily recommendations for optimal diet quality. Those in the highest quartile of AHEI had better FEV1 (adjusted (a)β 47.92, 95% CI 2.27–93.57) and FVC (aβ 80.23, 95% CI 34.03–126.42; p-value interaction (*) of AHEI and smoking >0.05) compared to those in quartile 1. Higher AHEI was also associated with lower odds of spirometric restriction (OR 0.23, 95% CI 0.08–0.67; p-value AHEI*ethnicity >0.05).Conclusions Diet quality was independently associated with better FEV1 and FVC and with lower odds of spirometric restriction. These findings highlight the need for research to further elucidate the possible beneficial role of diet in the preservation of lung function.

Journal article

Garcia-Larsen V, 2021, Omega-3 polyunsaturated fatty acids and FADS genotype: is personalised prevention of asthma on the horizon?, EUROPEAN RESPIRATORY JOURNAL, Vol: 58, ISSN: 0903-1936

Journal article

Benslimane A, Garcia-Larsen V, El Kinany K, Alaoui Chrifi A, Hatime Z, Benjelloun MC, El Biaze M, Nejjari C, El Rhazi Ket al., 2021, Association between obesity and chronic obstructive pulmonary disease in Moroccan adults: Evidence from the BOLD study, SAGE OPEN MEDICINE, Vol: 9, ISSN: 2050-3121

Journal article

Mendes FDC, Ducharme-Smith K, Mora-Garcia G, Alqahtani SA, Ruiz-Diaz MS, Moreira A, Villegas R, Garcia-Larsen Vet al., 2021, Household Food Insecurity, Lung Function, and COPD in US Adults, NUTRIENTS, Vol: 13

Journal article

Ducharme-Smith K, Chambers R, Garcia-Larsen V, Larzelere F, Kenney A, Reid R, Nelson L, Richards J, Begay M, Barlow A, Rosenstock Set al., 2021, Native Youth Participating in the Together on Diabetes 12-Month Home-Visiting Program Reported Improvements in Alternative Healthy Eating Index-2010 Diet Quality Domains Likely to Be Associated With Blood Pressure and Glycemic Control, JOURNAL OF THE ACADEMY OF NUTRITION AND DIETETICS, Vol: 121, Pages: 1125-1135, ISSN: 2212-2672

Journal article

de Castro Mendes F, Paciencia I, Rufo JC, Farraia M, Silva D, Padrao P, Delgado L, Garcia-Larsen V, Moreira A, Moreira Pet al., 2021, Increasing Vegetable Diversity Consumption Impacts the Sympathetic Nervous System Activity in School-Aged Children, NUTRIENTS, Vol: 13

Journal article

Ducharme-Smith K, Caulfield LE, Brady TM, Rosenstock S, Mueller NT, Garcia-Larsen Vet al., 2021, Higher Diet Quality in African-American Adolescents Is Associated with Lower Odds of Metabolic Syndrome: Evidence from the NHANES, JOURNAL OF NUTRITION, Vol: 151, Pages: 1609-1617, ISSN: 0022-3166

Journal article

Mendes FDC, Paciencia I, Cavaleiro Rufo J, Farraia M, Silva D, Padrao P, Delgado L, Garcia-Larsen V, Moreira A, Moreira Pet al., 2021, Higher diversity of vegetable consumption is associated with less airway inflammation and prevalence of asthma in school-aged children, PEDIATRIC ALLERGY AND IMMUNOLOGY, Vol: 32, Pages: 925-936, ISSN: 0905-6157

Journal article

Charles D, Gethings LA, Potts JF, Burney PGJ, Garcia-Larsen Vet al., 2021, Mass spectrometry-based metabolomics for the discovery of candidate markers of flavonoid and polyphenolic intake in adults, Scientific Reports, Vol: 11, ISSN: 2045-2322

Robust biological markers of dietary exposure are essential in improving the understanding of the link between diet and health outcomes. Polyphenolic compounds, including flavonoids, have been proposed to mitigate the risk of chronic diseases where oxidative stress and inflammation play a central role. Biomarkers can provide objective measurement of the levels of polyphenolic compounds. In this study, we provide methodology to identify potential candidate markers of polyphenol intake in human serum. Seventeen participants from the UK arm of the Global Allergy and Asthma Network of Excellence (GA2LEN) had their dietary intake estimated using a validated food frequency questionnaire, and serum samples were assessed using mass spectrometry to identify potential candidate markers. 144 features were assigned identities, of these we identified four biologically relevant compounds (rhamnazin 3-rutinoside, 2-galloyl-1,4-galactarolactone methyl ester, 2″,32″-di-O-p-coumaroylafzelin and cyclocommunin), which were significantly increased in the serum of participants with high predicted level of fruit and vegetable intake. 2-galloyl-1,4-galactarolactone methyl ester was strongly correlated with total flavonoids (r = 0.62; P = 0.005), flavan-3-ols (r = 0.67; P = 0.002) as well as with other four subclasses. Rhamnazin 3-rutinoside showed strong correlation with pro-anthocyanidins (r = 0.68; P = 0.001), flavones (r = 0.62; P = 0.005). Our results suggest that serum profiling for these compounds might be an effective way of establishing the relative intake of flavonoids and could contribute to improve the accuracy of epidemiological methods to ascertain flavonoid intake.

Journal article

Russell MA, Dharmage S, Fuertes E, Marcon A, Carsin A-E, Pascual Erquicia S, Heinrich J, Johannessen A, Abramson MJ, Amaral A, Cerveri I, Demoly P, Garcia-Larsen V, Jarvis D, Martinez-Moratalla J, Nowak D, Palacios-Gomez L, Squillacioti G, Raza W, Emtner M, Garcia-Aymerich Jet al., 2021, The effect of physical activity on asthma incidence over 10 years: population-based study, ERJ Open Research, Vol: 7, ISSN: 2312-0541

Journal article

Triebner K, Bifulco E, Barrera-Gomez J, Basagan X, Benediktsdottir B, Forsberg B, Franklin KA, Garcia-Larsen V, Leynaert B, Lindberg E, Martinez-Moratalla J, Muniozguren-Agirre N, Pin I, Raherison C, Pereira-Vega A, Schlunssen V, Valentin A, Hustad S, Real FG, Dadvand Pet al., 2021, Ultraviolet radiation as a predictor of sex hormone levels in postmenopausal women: A European multi-center study (ECRHS), MATURITAS, Vol: 145, Pages: 49-55, ISSN: 0378-5122

Journal article

Bernier-Jean A, Wong G, Saglimbene V, Ruospo M, Palmer S, Natale P, Garcia-Larsen V, Johnson DW, Tonelli M, Hegbran J, Craig JC, Teixeira-Pinto A, Strippoli GFMet al., 2020, PHYSICAL ACTIVITY AND MORTALITY IN ADULTS UNDERGOING HAEMODIALYSIS: A DIET-HD COHORT STUDY, Publisher: WILEY, Pages: 32-33, ISSN: 1320-5358

Conference paper

Bernier-Jean A, Wong G, Saglimbene V, Ruospo M, Palmer SC, Natale P, Garcia-Larsen V, Johnson DW, Tonelli M, Hegbrant J, Craig JC, Teixeira-Pinto A, Strippoli GFMet al., 2020, DIETARY POTASSIUM INTAKE AND ALL-CAUSE MORTALITY IN ADULTS UNDERGOING HEMODIALYSIS: THE DIET-HD COHORT STUDY, Publisher: WILEY, Pages: 10-10, ISSN: 1320-5358

Conference paper

Mattioli V, Zanolin ME, Cazzoletti L, Bono R, Cerveri I, Ferrari M, Pirina P, Garcia-Larsen Vet al., 2020, Dietary flavonoids and respiratory diseases: a population-based multi-case-control study in Italian adults, Public Health Nutrition, Vol: 23, Pages: 2548-2556, ISSN: 1368-9800

OBJECTIVE: To analyse the associations between chronic respiratory diseases and intakes of total flavonoids and their major subclasses (flavanones, anthocyanins, flavan-3-ols, flavonols, flavones, polymers and proanthocyanidins). DESIGN: Multi-case-control study. SETTING: The analysis was conducted in the frame of the Genes Environment Interaction in Respiratory Diseases (GEIRD) study. The European Prospective Investigation into Cancer and Nutrition FFQ was used to ascertain dietary intake. Multinomial regression models adjusting for age, sex, centre, BMI, smoking habit, alcohol intake, education, total energy intake, vitamin C intake and total fruit intake were used to examine the associations between dietary exposures and the relative risk ratio (RRR) of being a case. PARTICIPANTS: Individuals (n 990) hierarchically defined as follows: cases with asthma (current, n 159; past, n 78), chronic bronchitis (n 47), rhinitis (allergic rhinitis, n 167; non-allergic rhinitis, n 142) and controls (n 97). RESULTS: An increase of 1 sd in flavanones was associated with a reduced risk of non-allergic rhinitis (adjusted RRR = 0·68, 95 % CI 0·47, 0·97); a similar result was found comparing the highest v. lowest quartile of flavanones intake (adjusted RRR = 0·24, 95 % CI 0·10, 0·59). CONCLUSIONS: Flavonoids contained in fruits and vegetables, especially flavanones, might reduce the risk of non-allergic rhinitis. No associations were found between other flavonoids and the considered outcomes.

Journal article

Ducharme-Smith K, De Castro Mendes F, Villegas R, Mora-Garcia G, Stephany Ruiz-Diaz M, Moreira A, Garcia-Larsen Vet al., 2020, Late Breaking Abstract - Ventilatory function and diet quality in US adults - Evidence from the National Health and Nutrition Examination Survey (NHANES), Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936

Conference paper

Bédard A, Carsin A-E, Fuertes E, Accordini S, Dharmage SC, Garcia-Larsen V, Heinrich J, Janson C, Johannessen A, Leynaert B, Sánchez-Ramos JL, Peralta GP, Pin I, Squillacioti G, Weyler J, Jarvis D, Garcia-Aymerich Jet al., 2020, Physical activity and lung function - cause or consequence?, PLoS One, Vol: 15, ISSN: 1932-6203

Concerns exist that the positive association of physical activity with better lung function, which has been suggested in previous longitudinal studies in smokers, is due to reverse causation. To investigate this, we applied structural equation modeling (SEM), an exploratory approach, and marginal structural modeling (MSM), an approach from the causal inference framework that corrects for reverse causation and time-dependent confounding and estimates causal effects, on data from participants in the European Community Respiratory Health Survey (ECRHS, a multicentre European cohort study initiated in 1991–1993 with ECRHS I, and with two follow-ups: ECRHS II in 1999–2003, and ECRHS III in 2010–2014). 753 subjects who reported current smoking at ECRHS II, with repeated data on lung function at ECRHS I, II and III, physical activity at ECRHS II and III, and potential confounders at ECRHS I and II, were included in the analyses. SEM showed positive associations between physical activity and lung function in both directions. MSM suggested a protective causal effect of physical activity on lung function (overall difference in mean β (95% CI), comparing active versus non-active individuals: 58 mL (21–95) for forced expiratory volume in one second and 83 mL (36–130) for forced vital capacity). Our results suggest bi-directional causation and support a true protective effect of physical activity on lung function in smokers, after accounting for reverse causation and time-dependent confounding.

Journal article

Mora-Garcia G, Stephany Ruiz-Diaz M, Villegas R, Garcia-Larsen Vet al., 2020, Changes in diet quality over 10 years of nutrition transition in Colombia: analysis of the 2005 and 2015 nationally representative cross-sectional surveys, INTERNATIONAL JOURNAL OF PUBLIC HEALTH, Vol: 65, Pages: 547-558, ISSN: 1661-8556

Journal article

del Giacco S, Couto M, Firinu D, Garcia-Larsen Vet al., 2020, Management of Intermittent and Persistent Asthma in Adolescent and High School Athletes, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, Vol: 8, Pages: 2166-2181, ISSN: 2213-2198

Journal article

Chamitava L, Cazzoletti L, Ferrari M, Garcia-Larsen V, Jalil A, Degan P, Fois AG, Zinellu E, Fois SS, Pasini AMF, Nicolis M, Olivieri M, Corsico A, Bono R, Pirina P, Zanolin MEet al., 2020, Biomarkers of Oxidative Stress and Inflammation in Chronic Airway Diseases, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, Vol: 21

Journal article

Jarrold K, Helfer B, Eskander M, Crawley H, Trabulsi J, Caulfield LE, Duffy G, Garcia-Larsen V, Hayward D, Hyde M, Jeffries S, Knip M, Leonardi-Bee J, Loder E, Lodge CJ, Lowe AJ, McGuire W, Osborn D, Przyrembel H, Renfrew MJ, Trumbo P, Warner J, Schneeman B, Boyle RJet al., 2020, Guidance for the conduct and reporting of clinical trials of breast milk substitutes., JAMA Pediatrics, ISSN: 2168-6203

Importance: Breast milk substitutes (BMS) are important nutritional products evaluated in clinical trials. Concerns have been raised about the risk of bias in BMS trials, the reliability of claims that arise from such trials, and the potential for BMS trials to undermine breastfeeding in trial participants. Existing clinical trial guidance does not fully address issues specific to BMS trials. Objectives: To establish new methodological criteria to guide the design, conduct, analysis, and reporting of BMS trials and to support clinical trialists designing and undertaking BMS trials, editors and peer reviewers assessing trial reports for publication, and regulators evaluating the safety, nutritional adequacy, and efficacy of BMS products. Design, Setting, and Participants: A modified Delphi method was conducted, involving 3 rounds of anonymous questionnaires and a face-to-face consensus meeting between January 1 and October 24, 2018. Participants were 23 experts in BMS trials, BMS regulation, trial methods, breastfeeding support, infant feeding research, and medical publishing, and were affiliated with institutions across Europe, North America, and Australasia. Guidance development was supported by an industry consultation, analysis of methodological issues in a sample of published BMS trials, and consultations with BMS trial participants and a research ethics committee. Results: An initial 73 criteria, derived from the literature, were sent to the experts. The final consensus guidance contains 54 essential criteria and 4 recommended criteria. An 18-point checklist summarizes the criteria that are specific to BMS trials. Key themes emphasized in the guidance are research integrity and transparency of reporting, supporting breastfeeding in trial participants, accurate description of trial interventions, and use of valid and meaningful outcome measures. Conclusions and Relevance: Implementation of this guidance should enhance the quality and validity of BMS trials, prot

Journal article

Mora-García G, Trujillo A, García-Larsen V, 2020, Diet quality, general health and anthropometric outcomes in a Latin American population: evidence from the Colombian National Nutritional Survey (ENSIN) 2010., Public Health Nutr, Pages: 1-8

OBJECTIVE: Colombia is experiencing a nutrition transition, characterised by nutritionally poor diets and an increased prevalence of non-communicable diseases (NCD). We aimed to investigate the association between diet quality and general health outcomes related to the risk of NCD, in a nationally representative sample of Colombian adolescents and adults. DESIGN: Cross-sectional analysis. The Alternative Healthy-Eating Index (AHEI) was derived to calculate diet quality. Adjusted regressions were used to examine the association between AHEI, self-perceived general health status (GHS) and anthropometric variables (i.e. age-specific z-scores for height, and BMI for adolescents; waist circumference and BMI for adults). SETTING: Nationally representative data from the Colombian National Nutrition Survey (ENSIN) 2010. PARTICIPANTS: Adolescents aged 10-17 years (n 6566) and adults aged ≥18 years (n 6750). RESULTS: AHEI scores were similar between adolescents (mean 29·3 ± 7·2) and adults (mean 30·5 ± 7·2). In the whole sample, a better diet quality (higher AHEI score) was associated with worse self-perceived GHS (adjusted (a) β-coefficient: -0·004; P < 0·001) and with a smaller waist circumference ((a) β-coefficient: -0·06; P < 0·01). In adults, a higher AHEI score was negatively associated with BMI ((a) β-coefficient: -0·02; P < 0·05), whilst in adolescents it was associated with a reduced height-for-age z-score ((a) β-coefficient: -0·009; P < 0·001). CONCLUSIONS: A better diet quality was associated with reduced prevalence of predictors of NCD and with some indicators of general health in the Colombian population. In light of the high prevalence of overweight, our findings support the need for public health interventions focused on sustainable positive changes in dietary habits in the general population.

Journal article

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