126 results found
Garcia-Larsen V, 2021, Omega-3 polyunsaturated fatty acids and FADS genotype: is personalised prevention of asthma on the horizon?, Eur Respir J, Vol: 58
Benslimane A, Garcia-Larsen V, El Kinany K, et al., 2021, Association between obesity and chronic obstructive pulmonary disease in Moroccan adults: Evidence from the BOLD study, SAGE OPEN MEDICINE, Vol: 9, ISSN: 2050-3121
Mendes FDC, Ducharme-Smith K, Mora-Garcia G, et al., 2021, Household Food Insecurity, Lung Function, and COPD in US Adults, NUTRIENTS, Vol: 13
Ducharme-Smith K, Chambers R, Garcia-Larsen V, et al., 2021, Native Youth Participating in the Together on Diabetes 12-Month Home-Visiting Program Reported Improvements in Alternative Healthy Eating Index-2010 Diet Quality Domains Likely to Be Associated With Blood Pressure and Glycemic Control, JOURNAL OF THE ACADEMY OF NUTRITION AND DIETETICS, Vol: 121, Pages: 1125-1135, ISSN: 2212-2672
Ducharme-Smith K, Caulfield LE, Brady TM, et al., 2021, Higher Diet Quality in African-American Adolescents Is Associated with Lower Odds of Metabolic Syndrome: Evidence from the NHANES, JOURNAL OF NUTRITION, Vol: 151, Pages: 1609-1617, ISSN: 0022-3166
de Castro Mendes F, Paciencia I, Rufo JC, et al., 2021, Increasing Vegetable Diversity Consumption Impacts the Sympathetic Nervous System Activity in School-Aged Children, NUTRIENTS, Vol: 13
Paudyal N, Parajuli KR, Garcia Larsen V, et al., 2021, A review of the maternal iron and folic acid supplementation programme in Nepal: Achievements and challenges, Maternal and Child Nutrition, ISSN: 1740-8695
In the late 1990s, an estimated 75% of pregnant women in Nepal were anaemic. Although iron and folic acid (IFA) supplements were available free of charge, coverage among pregnant women was very low. In response, the Government of Nepal launched the Iron Intensification Programme (IIP) in 2003 to improve the coverage of IFA supplementation and anthelminthic treatment during pregnancy, as well as promote the utilization of antenatal care. This review examined how the IIP programme contributed to Nepal's success in increasing the consumption of IFA supplements during pregnancy. Nepal's cadre of Female Community Health Volunteers were engaged in the IIP to support the community-based distribution of IFA supplements to pregnant women and complement IFA distribution through health facilities and outreach services. As a result, the country achieved a fourfold increase in the proportion of women who took IFA supplements during pregnancy between 2001 and 2016 (from 23% to 91%) and a 12-fold increase in the proportion who took IFA supplements for at least 90 days during pregnancy (from 6% to 71%). The increase in coverage of IFA supplements accompanied an increase in the coverage of antenatal care during the same period. By 2016, the prevalence of anaemia in pregnant women decreased to 46%, highlighting the need to tackle other causes of anaemia and improve haemoglobin concentration before pregnancy, while maintaining the successful efforts to reach pregnant women with IFA supplements at the community level.
Mendes FDC, Paciencia I, Cavaleiro Rufo J, et al., 2021, Higher diversity of vegetable consumption is associated with less airway inflammation and prevalence of asthma in school-aged children, PEDIATRIC ALLERGY AND IMMUNOLOGY, Vol: 32, Pages: 925-936, ISSN: 0905-6157
Charles D, Gethings LA, Potts JF, et al., 2021, Mass spectrometry-based metabolomics for the discovery of candidate markers of flavonoid and polyphenolic intake in adults, Scientific Reports, Vol: 11, ISSN: 2045-2322
Robust biological markers of dietary exposure are essential in improving the understanding of the link between diet and health outcomes. Polyphenolic compounds, including flavonoids, have been proposed to mitigate the risk of chronic diseases where oxidative stress and inflammation play a central role. Biomarkers can provide objective measurement of the levels of polyphenolic compounds. In this study, we provide methodology to identify potential candidate markers of polyphenol intake in human serum. Seventeen participants from the UK arm of the Global Allergy and Asthma Network of Excellence (GA2LEN) had their dietary intake estimated using a validated food frequency questionnaire, and serum samples were assessed using mass spectrometry to identify potential candidate markers. 144 features were assigned identities, of these we identified four biologically relevant compounds (rhamnazin 3-rutinoside, 2-galloyl-1,4-galactarolactone methyl ester, 2″,32″-di-O-p-coumaroylafzelin and cyclocommunin), which were significantly increased in the serum of participants with high predicted level of fruit and vegetable intake. 2-galloyl-1,4-galactarolactone methyl ester was strongly correlated with total flavonoids (r = 0.62; P = 0.005), flavan-3-ols (r = 0.67; P = 0.002) as well as with other four subclasses. Rhamnazin 3-rutinoside showed strong correlation with pro-anthocyanidins (r = 0.68; P = 0.001), flavones (r = 0.62; P = 0.005). Our results suggest that serum profiling for these compounds might be an effective way of establishing the relative intake of flavonoids and could contribute to improve the accuracy of epidemiological methods to ascertain flavonoid intake.
Triebner K, Bifulco E, Barrera-Gomez J, et al., 2021, Ultraviolet radiation as a predictor of sex hormone levels in postmenopausal women: A European multi-center study (ECRHS), MATURITAS, Vol: 145, Pages: 49-55, ISSN: 0378-5122
Russell MA, Dharmage S, Fuertes E, et al., 2021, The effect of physical activity on asthma incidence over 10 years: population-based study, ERJ Open Research, Vol: 7, ISSN: 2312-0541
Bernier-Jean A, Wong G, Saglimbene V, et al., 2020, PHYSICAL ACTIVITY AND MORTALITY IN ADULTS UNDERGOING HAEMODIALYSIS: A DIET-HD COHORT STUDY, Publisher: WILEY, Pages: 32-33, ISSN: 1320-5358
Bernier-Jean A, Wong G, Saglimbene V, et al., 2020, DIETARY POTASSIUM INTAKE AND ALL-CAUSE MORTALITY IN ADULTS UNDERGOING HEMODIALYSIS: THE DIET-HD COHORT STUDY, Publisher: WILEY, Pages: 10-10, ISSN: 1320-5358
Mattioli V, Zanolin ME, Cazzoletti L, et al., 2020, Dietary flavonoids and respiratory diseases: a population-based multi-case-control study in Italian adults, Public Health Nutrition, Vol: 23, Pages: 2548-2556, ISSN: 1368-9800
OBJECTIVE: To analyse the associations between chronic respiratory diseases and intakes of total flavonoids and their major subclasses (flavanones, anthocyanins, flavan-3-ols, flavonols, flavones, polymers and proanthocyanidins). DESIGN: Multi-case-control study. SETTING: The analysis was conducted in the frame of the Genes Environment Interaction in Respiratory Diseases (GEIRD) study. The European Prospective Investigation into Cancer and Nutrition FFQ was used to ascertain dietary intake. Multinomial regression models adjusting for age, sex, centre, BMI, smoking habit, alcohol intake, education, total energy intake, vitamin C intake and total fruit intake were used to examine the associations between dietary exposures and the relative risk ratio (RRR) of being a case. PARTICIPANTS: Individuals (n 990) hierarchically defined as follows: cases with asthma (current, n 159; past, n 78), chronic bronchitis (n 47), rhinitis (allergic rhinitis, n 167; non-allergic rhinitis, n 142) and controls (n 97). RESULTS: An increase of 1 sd in flavanones was associated with a reduced risk of non-allergic rhinitis (adjusted RRR = 0·68, 95 % CI 0·47, 0·97); a similar result was found comparing the highest v. lowest quartile of flavanones intake (adjusted RRR = 0·24, 95 % CI 0·10, 0·59). CONCLUSIONS: Flavonoids contained in fruits and vegetables, especially flavanones, might reduce the risk of non-allergic rhinitis. No associations were found between other flavonoids and the considered outcomes.
Ducharme-Smith K, De Castro Mendes F, Villegas R, et al., 2020, Late Breaking Abstract - Ventilatory function and diet quality in US adults - Evidence from the National Health and Nutrition Examination Survey (NHANES), Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936
Bédard A, Carsin A-E, Fuertes E, et al., 2020, Physical activity and lung function - cause or consequence?, PLoS One, Vol: 15, ISSN: 1932-6203
Concerns exist that the positive association of physical activity with better lung function, which has been suggested in previous longitudinal studies in smokers, is due to reverse causation. To investigate this, we applied structural equation modeling (SEM), an exploratory approach, and marginal structural modeling (MSM), an approach from the causal inference framework that corrects for reverse causation and time-dependent confounding and estimates causal effects, on data from participants in the European Community Respiratory Health Survey (ECRHS, a multicentre European cohort study initiated in 1991–1993 with ECRHS I, and with two follow-ups: ECRHS II in 1999–2003, and ECRHS III in 2010–2014). 753 subjects who reported current smoking at ECRHS II, with repeated data on lung function at ECRHS I, II and III, physical activity at ECRHS II and III, and potential confounders at ECRHS I and II, were included in the analyses. SEM showed positive associations between physical activity and lung function in both directions. MSM suggested a protective causal effect of physical activity on lung function (overall difference in mean β (95% CI), comparing active versus non-active individuals: 58 mL (21–95) for forced expiratory volume in one second and 83 mL (36–130) for forced vital capacity). Our results suggest bi-directional causation and support a true protective effect of physical activity on lung function in smokers, after accounting for reverse causation and time-dependent confounding.
Mora-Garcia G, Stephany Ruiz-Diaz M, Villegas R, et al., 2020, Changes in diet quality over 10 years of nutrition transition in Colombia: analysis of the 2005 and 2015 nationally representative cross-sectional surveys, INTERNATIONAL JOURNAL OF PUBLIC HEALTH, Vol: 65, Pages: 547-558, ISSN: 1661-8556
del Giacco S, Couto M, Firinu D, et al., 2020, Management of Intermittent and Persistent Asthma in Adolescent and High School Athletes, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, Vol: 8, Pages: 2166-2181, ISSN: 2213-2198
Chamitava L, Cazzoletti L, Ferrari M, et al., 2020, Biomarkers of Oxidative Stress and Inflammation in Chronic Airway Diseases, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, Vol: 21
Mora-García G, Trujillo A, García-Larsen V, 2020, Diet quality, general health and anthropometric outcomes in a Latin American population: evidence from the Colombian National Nutritional Survey (ENSIN) 2010., Public Health Nutr, Pages: 1-8
OBJECTIVE: Colombia is experiencing a nutrition transition, characterised by nutritionally poor diets and an increased prevalence of non-communicable diseases (NCD). We aimed to investigate the association between diet quality and general health outcomes related to the risk of NCD, in a nationally representative sample of Colombian adolescents and adults. DESIGN: Cross-sectional analysis. The Alternative Healthy-Eating Index (AHEI) was derived to calculate diet quality. Adjusted regressions were used to examine the association between AHEI, self-perceived general health status (GHS) and anthropometric variables (i.e. age-specific z-scores for height, and BMI for adolescents; waist circumference and BMI for adults). SETTING: Nationally representative data from the Colombian National Nutrition Survey (ENSIN) 2010. PARTICIPANTS: Adolescents aged 10-17 years (n 6566) and adults aged ≥18 years (n 6750). RESULTS: AHEI scores were similar between adolescents (mean 29·3 ± 7·2) and adults (mean 30·5 ± 7·2). In the whole sample, a better diet quality (higher AHEI score) was associated with worse self-perceived GHS (adjusted (a) β-coefficient: -0·004; P < 0·001) and with a smaller waist circumference ((a) β-coefficient: -0·06; P < 0·01). In adults, a higher AHEI score was negatively associated with BMI ((a) β-coefficient: -0·02; P < 0·05), whilst in adolescents it was associated with a reduced height-for-age z-score ((a) β-coefficient: -0·009; P < 0·001). CONCLUSIONS: A better diet quality was associated with reduced prevalence of predictors of NCD and with some indicators of general health in the Colombian population. In light of the high prevalence of overweight, our findings support the need for public health interventions focused on sustainable positive changes in dietary habits in the general population.
Jarrold K, Helfer B, Eskander M, et al., 2020, Guidance for the conduct and reporting of clinical trials of breast milk substitutes., JAMA Pediatrics, ISSN: 2168-6203
Importance: Breast milk substitutes (BMS) are important nutritional products evaluated in clinical trials. Concerns have been raised about the risk of bias in BMS trials, the reliability of claims that arise from such trials, and the potential for BMS trials to undermine breastfeeding in trial participants. Existing clinical trial guidance does not fully address issues specific to BMS trials. Objectives: To establish new methodological criteria to guide the design, conduct, analysis, and reporting of BMS trials and to support clinical trialists designing and undertaking BMS trials, editors and peer reviewers assessing trial reports for publication, and regulators evaluating the safety, nutritional adequacy, and efficacy of BMS products. Design, Setting, and Participants: A modified Delphi method was conducted, involving 3 rounds of anonymous questionnaires and a face-to-face consensus meeting between January 1 and October 24, 2018. Participants were 23 experts in BMS trials, BMS regulation, trial methods, breastfeeding support, infant feeding research, and medical publishing, and were affiliated with institutions across Europe, North America, and Australasia. Guidance development was supported by an industry consultation, analysis of methodological issues in a sample of published BMS trials, and consultations with BMS trial participants and a research ethics committee. Results: An initial 73 criteria, derived from the literature, were sent to the experts. The final consensus guidance contains 54 essential criteria and 4 recommended criteria. An 18-point checklist summarizes the criteria that are specific to BMS trials. Key themes emphasized in the guidance are research integrity and transparency of reporting, supporting breastfeeding in trial participants, accurate description of trial interventions, and use of valid and meaningful outcome measures. Conclusions and Relevance: Implementation of this guidance should enhance the quality and validity of BMS trials, prot
Bjornsdottir E, Lindberg E, Benediktsdottir B, et al., 2020, Are symptoms of insomnia related to respiratory symptoms? Cross-sectional results from 10 European countries and Australia., BMJ Open, Vol: 10, Pages: 1-8, ISSN: 2044-6055
OBJECTIVES: To compare the prevalence of different insomnia subtypes among middle-aged adults from Europe and Australia and to explore the cross-sectional relationship between insomnia subtypes, respiratory symptoms and lung function. DESIGN: Cross-sectional population-based, multicentre cohort study. SETTING: 23 centres in 10 European countries and Australia. METHODS: We included 5800 participants in the third follow-up of the European Community Respiratory Health Survey III (ECRHS III) who answered three questions on insomnia symptoms: difficulties falling asleep (initial insomnia), waking up often during the night (middle insomnia) and waking up early in the morning and not being able to fall back asleep (late insomnia). They also answered questions on smoking, general health and chronic diseases and had the following lung function measurements: forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and the FEV1/FVC ratio. Changes in lung function since ECRHS I about 20 years earlier were also analysed. MAIN OUTCOME MEASURES: Prevalence of insomnia subtypes and relationship to respiratory symptoms and function. RESULTS: Overall, middle insomnia (31.2%) was the most common subtype followed by late insomnia (14.2%) and initial insomnia (11.2%). The highest reported prevalence of middle insomnia was found in Iceland (37.2%) and the lowest in Australia (22.7%), while the prevalence of initial and late insomnia was highest in Spain (16.0% and 19.7%, respectively) and lowest in Denmark (4.6% and 9.2%, respectively). All subtypes of insomnia were associated with significantly higher reported prevalence of respiratory symptoms. Only isolated initial insomnia was associated with lower FEV1, whereas no association was found between insomnia and low FEV1/FVC ratio or decline in lung function. CONCLUSION: There is considerable geographical variation in the prevalence of insomnia symptoms. Middle insomnia is most common especially in Iceland. Initial and l
Kim H, Rebholz CM, Garcia-Larsen V, et al., 2020, Operational Differences in Plant-Based Diet Indices Affect the Ability to Detect Associations with Incident Hypertension in Middle-Aged US Adults, JOURNAL OF NUTRITION, Vol: 150, Pages: 842-850, ISSN: 0022-3166
de Castro Mendes F, Paciência I, Cavaleiro Rufo J, et al., 2020, The inflammatory potential of diet impacts the association between air pollution and childhood asthma., Pediatric Allergy and Immunology, Vol: 31, Pages: 290-296, ISSN: 0905-6157
BACKGROUND: Inhalation of fine particulate matter (PM) can cause systematic inflammation and oxidative stress, which may further aggravate the development and progression of asthma. Although nutritional intake of fatty acids and antioxidants may attenuate some effects of fine PM, the role of the inflammatory potential of diet has not been addressed. Therefore, we aimed to investigate possible modulatory effects of dietary inflammatory potential on the association of indoor air pollution and childhood asthma-related outcomes. METHODS: In a sample of 501 children (48.1% males, aged 7 to 12 years) from 20 public schools located in Porto, Portugal, we evaluated airway reversibility, exhaled nitric oxide levels, atopy and current respiratory symptoms. Dietary inflammatory index was calculated based on information collected through a reported 24-hour recall questionnaire, and participants were categorized as having an anti-inflammatory or pro-inflammatory diet. Concentrations of indoor PM2.5 and PM10 were measured to assess indoor air quality. Generalized linear mixed models were used to investigate the proportion of effects explained by the exposures to PM2.5 and PM10. RESULTS: After adjustment, the exposure effect of PM2.5 and PM10 levels on children with asthma was higher for those having a pro-inflammatory diet (OR= 1.44, 95% CI: 1.01 to 2.21 and OR=1.29, 95% CI: 1.03 to 1.68, respectively) compared to those having an anti-inflammatory diet. CONCLUSION: These findings suggest that the quality of diet might affect the association of indoor pollution and asthma in children, highlighting the relevance of children's diet as a potential protective factor to pollutants exposure in childhood asthma.
Khalis M, Garcia-Larsen V, Charaka H, et al., 2020, Update of the Moroccan food composition tables: Towards a more reliable tool for nutrition research, Journal of Food Composition and Analysis, Vol: 87, Pages: 103397-103397, ISSN: 0889-1575
Amaral A, Burney P, Fuertes E, et al., 2020, Body mass index and weight change are associated with adult lung function trajectories: a prospective European survey, Thorax, Vol: 4, Pages: 313-320, ISSN: 0040-6376
Background: Previous studies have reported an association between weight increase and excess lung function decline in young adults followed for short periods. We aimed to estimate lung function trajectories during adulthood according to 20-years weight change profiles, using data from the population-based European Community Respiratory Health Survey (ECRHS).Methods: We included 3,673 participants recruited at age 20-44 years with repeated measurements of weight and lung function (FVC, FEV1) in three study waves (1991-93, 1999-2003, 2010-14) until they were 39-67 years. We classified subjects into weight change profiles according to baseline BMI categories and weight change over 20 years. We estimated trajectories of lung function over time as a function of weight change profiles using population-averaged generalised estimating equations.Results: In individuals with normal BMI, overweight and obesity at baseline, moderate (0.25–1kg/year) and high weight gain (>1kg/year) during follow-up were associated with accelerated FVC and FEV1 declines. Compared to participants with baseline normal BMI and stable weight (±0.25kg/year), obese with high weight gain during follow-up had -1,011 ml [95%CI: -1,259 to -763] lower estimated FVC at 65 years, despite similar estimated FVC levels at 25 years. Obese individuals at baseline who lost weight (<-0.25kg/year) exhibited an attenuation of FVC and FEV1 declines. We found no association between weight change profiles and FEV1/FVC decline. Conclusion: Moderate and high weight gain over 20-years was associated with accelerated lung function decline, while weight loss was related to its attenuation. Control of weight gain is important for maintaining good lung function in adult life.
Saglimbene VM, Wong G, Teixeira-Pinto A, et al., 2020, Dietary Patterns and Mortality in a Multinational Cohort of Adults Receiving Hemodialysis, AMERICAN JOURNAL OF KIDNEY DISEASES, Vol: 75, Pages: 361-372, ISSN: 0272-6386
Mendes FC, Paciencia I, Rufo JC, et al., 2020, The Association Between Vegetable Diversity Intake, Airway Inflammation and Asthma in Portuguese Primary School Children, International Conference of the American-Thoracic-Society, Publisher: AMER THORACIC SOC, ISSN: 1073-449X
Roberts G, Grimshaw K, Beyer K, et al., 2019, Can dietary strategies in early life prevent childhood food allergy? A report from two iFAAM workshops, Clinical and Experimental Allergy, Vol: 49, Pages: 1567-1577, ISSN: 0954-7894
Food allergy affects a small but significant number of children and adults. Food allergy is responsible for considerable morbidity and is the commonest cause of anaphylaxis in children. One of the aims of the European Union‐funded “Integrated Approaches to Food Allergen and Allergy Risk Management” (iFAAM) project was to improve our understanding of the best way to prevent the development of food allergy. Groups within the project worked on integrating the current prevention evidence base as well as generating new data to move our understanding forward. This paper from the iFAAM project is a unique addition to the literature on this topic as it not only outlines the recently published randomized controlled trials (as have previous reviews) but also summarizes two iFAAM‐associated project workshops. These workshops focused on how we may be able to use dietary strategies in early life to prevent the development of food allergy and summarized the range of opinions amongst experts in this controversial area.
Triebner K, Hustad S, Barrera J, et al., 2019, Late Breaking Abstract - Ultraviolet radiation and lung function in aging women: A European multi-centre study (ECRHS), European-Respiratory-Society (ERS) International Congress, Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936
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