Imperial College London

DrVanessaGarcia Larsen

Faculty of MedicineNational Heart & Lung Institute

Honorary Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 7945vgla

 
 
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Location

 

61Emmanuel Kaye BuildingRoyal Brompton Campus

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Summary

 

Publications

Publication Type
Year
to

146 results found

Bernier-Jean A, Wong G, Saglimbene V, Ruospo M, Palmer S, Natale P, Garcia-Larsen V, Johnson DW, Tonelli M, Hegbran J, Craig JC, Teixeira-Pinto A, Strippoli GFMet al., 2020, PHYSICAL ACTIVITY AND MORTALITY IN ADULTS UNDERGOING HAEMODIALYSIS: A DIET-HD COHORT STUDY, Publisher: WILEY, Pages: 32-33, ISSN: 1320-5358

Conference paper

Bernier-Jean A, Wong G, Saglimbene V, Ruospo M, Palmer SC, Natale P, Garcia-Larsen V, Johnson DW, Tonelli M, Hegbrant J, Craig JC, Teixeira-Pinto A, Strippoli GFMet al., 2020, DIETARY POTASSIUM INTAKE AND ALL-CAUSE MORTALITY IN ADULTS UNDERGOING HEMODIALYSIS: THE DIET-HD COHORT STUDY, Publisher: WILEY, Pages: 10-10, ISSN: 1320-5358

Conference paper

Mattioli V, Zanolin ME, Cazzoletti L, Bono R, Cerveri I, Ferrari M, Pirina P, Garcia-Larsen Vet al., 2020, Dietary flavonoids and respiratory diseases: a population-based multi-case-control study in Italian adults, Public Health Nutrition, Vol: 23, Pages: 2548-2556, ISSN: 1368-9800

OBJECTIVE: To analyse the associations between chronic respiratory diseases and intakes of total flavonoids and their major subclasses (flavanones, anthocyanins, flavan-3-ols, flavonols, flavones, polymers and proanthocyanidins). DESIGN: Multi-case-control study. SETTING: The analysis was conducted in the frame of the Genes Environment Interaction in Respiratory Diseases (GEIRD) study. The European Prospective Investigation into Cancer and Nutrition FFQ was used to ascertain dietary intake. Multinomial regression models adjusting for age, sex, centre, BMI, smoking habit, alcohol intake, education, total energy intake, vitamin C intake and total fruit intake were used to examine the associations between dietary exposures and the relative risk ratio (RRR) of being a case. PARTICIPANTS: Individuals (n 990) hierarchically defined as follows: cases with asthma (current, n 159; past, n 78), chronic bronchitis (n 47), rhinitis (allergic rhinitis, n 167; non-allergic rhinitis, n 142) and controls (n 97). RESULTS: An increase of 1 sd in flavanones was associated with a reduced risk of non-allergic rhinitis (adjusted RRR = 0·68, 95 % CI 0·47, 0·97); a similar result was found comparing the highest v. lowest quartile of flavanones intake (adjusted RRR = 0·24, 95 % CI 0·10, 0·59). CONCLUSIONS: Flavonoids contained in fruits and vegetables, especially flavanones, might reduce the risk of non-allergic rhinitis. No associations were found between other flavonoids and the considered outcomes.

Journal article

Ducharme-Smith K, De Castro Mendes F, Villegas R, Mora-Garcia G, Stephany Ruiz-Diaz M, Moreira A, Garcia-Larsen Vet al., 2020, Late Breaking Abstract - Ventilatory function and diet quality in US adults - Evidence from the National Health and Nutrition Examination Survey (NHANES), Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936

Conference paper

Bédard A, Carsin A-E, Fuertes E, Accordini S, Dharmage SC, Garcia-Larsen V, Heinrich J, Janson C, Johannessen A, Leynaert B, Sánchez-Ramos JL, Peralta GP, Pin I, Squillacioti G, Weyler J, Jarvis D, Garcia-Aymerich Jet al., 2020, Physical activity and lung function - cause or consequence?, PLoS One, Vol: 15, ISSN: 1932-6203

Concerns exist that the positive association of physical activity with better lung function, which has been suggested in previous longitudinal studies in smokers, is due to reverse causation. To investigate this, we applied structural equation modeling (SEM), an exploratory approach, and marginal structural modeling (MSM), an approach from the causal inference framework that corrects for reverse causation and time-dependent confounding and estimates causal effects, on data from participants in the European Community Respiratory Health Survey (ECRHS, a multicentre European cohort study initiated in 1991–1993 with ECRHS I, and with two follow-ups: ECRHS II in 1999–2003, and ECRHS III in 2010–2014). 753 subjects who reported current smoking at ECRHS II, with repeated data on lung function at ECRHS I, II and III, physical activity at ECRHS II and III, and potential confounders at ECRHS I and II, were included in the analyses. SEM showed positive associations between physical activity and lung function in both directions. MSM suggested a protective causal effect of physical activity on lung function (overall difference in mean β (95% CI), comparing active versus non-active individuals: 58 mL (21–95) for forced expiratory volume in one second and 83 mL (36–130) for forced vital capacity). Our results suggest bi-directional causation and support a true protective effect of physical activity on lung function in smokers, after accounting for reverse causation and time-dependent confounding.

Journal article

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