Imperial College London
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DrVanessaGarcia Larsen

Faculty of Medicine, National Heart & Lung Institute

Honorary Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 7945vgla

 
 
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Location

 

61Emmanuel Kaye BuildingRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Poudyal:2022:10.1136/bmjopen-2021-057509,
author = {Poudyal, A and Karki, KB and Shrestha, N and Aryal, KK and Mahato, NK and Bista, B and Ghimire, L and Kc, D and Gyanwali, P and Jha, AK and Garcia-Larsen, V and Kuch, U and Groneberg, DA and Sharma, SK and Dhimal, M},
doi = {10.1136/bmjopen-2021-057509},
journal = {BMJ Open},
pages = {e057509--e057509},
title = {Prevalence and risk factors associated with chronic kidney disease in Nepal: evidence from a nationally representative population-based cross-sectional study.},
url = {http://dx.doi.org/10.1136/bmjopen-2021-057509},
volume = {12},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - OBJECTIVE: This study aimed to determine population-based prevalence of chronic kidney disease (CKD) and its associated factors in Nepal. STUDY DESIGN: The study was a nationwide population-based cross-sectional study. SETTING AND PARTICIPANTS: Cross-sectional survey conducted in a nationally representative sample of 12 109 Nepalese adult from 2016 to 2018 on selected chronic non-communicable diseases was examined. Multistage cluster sampling with a mix of probability proportionate to size and systematic random sampling was used for the selection of individuals aged 20 years and above. PRIMARY AND SECONDARY OUTCOME MEASURES: Primary outcome in this study was population-based prevalence of CKD in Nepal. A participant was considered to have CKD if the urine albumin-to-creatinine ratio was greater than or equal to 30 mg/g and/or estimated glomerular filtration rate is less than 60 mL/min/1.73 m2 at baseline and in follow-up using modification of diet in renal disease study equations. The secondary outcome measure was factors associated with CKD in Nepal. The covariate adjusted association of risk factors and CKD was calculated using multivariable binary logistic regression. RESULTS: The overall prevalence of CKD in Nepal was 6.0% (95% CI 5.5 to 6.6). Factors independently associated with CKD included older age (adjusted OR (AOR) 2.6, 95% CI 1.9 to 3.6), Dalit caste (AOR 1.6, 95% CI 1.1 to 2.3), hypertension (AOR 2.4, 95% CI 2.0 to 3.0), diabetes mellitus (AOR 3.2, 95% CI 2.5 to 4.1), raised total cholesterol (AOR 1.3, 95% CI 1.0 to 1.6) and increased waist-to-hip ratio (AOR 1.6, 95% CI 1.2 to 2.3). CONCLUSION: This nationally representative study shows that the prevalence of CKD in the adult population of Nepal is substantial, and it is independently associated with several cardiometabolic traits. These findings warrant longitudinal studies to identify the causes of CKD in Nepal and effective strategies to
AU  - Poudyal,A
AU  - Karki,KB
AU  - Shrestha,N
AU  - Aryal,KK
AU  - Mahato,NK
AU  - Bista,B
AU  - Ghimire,L
AU  - Kc,D
AU  - Gyanwali,P
AU  - Jha,AK
AU  - Garcia-Larsen,V
AU  - Kuch,U
AU  - Groneberg,DA
AU  - Sharma,SK
AU  - Dhimal,M
DO  - 10.1136/bmjopen-2021-057509
EP  - 057509
PY  - 2022///
SN  - 2044-6055
SP  - 057509
TI  - Prevalence and risk factors associated with chronic kidney disease in Nepal: evidence from a nationally representative population-based cross-sectional study.
T2  - BMJ Open
UR  - http://dx.doi.org/10.1136/bmjopen-2021-057509
UR  - https://www.ncbi.nlm.nih.gov/pubmed/35314475
UR  - https://bmjopen.bmj.com/content/12/3/e057509.info
UR  - http://hdl.handle.net/10044/1/95991
VL  - 12
ER  -
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