485 results found
Asfour V, Gibbs K, Wertheim D, et al., 2021, Anal canal to pubis angle: a novel clinical ultrasound technique for the assessment of the anorectal region, INTERNATIONAL UROGYNECOLOGY JOURNAL, ISSN: 0937-3462
Cartwright J, Frankin L, Tikkinen K, et al., 2021, Genome wide association study identifies two novel loci associated with female stress and urgency urinary incontinence, The Journal of Urology, ISSN: 0022-5347
Background:Genome-wide association studies (GWAS) have not identified replicable genetic risk loci for stress or urgency urinary incontinence.Methods:We carried out a discovery stage case control GWAS in three independent discovery cohorts of European women (n=8,979) for stress incontinence, urgency incontinence, and any incontinence phenotypes. We conducted replication in six additional studies of European ancestry (n=4,069). We collected bladder biopsies from women with incontinence to further investigate bladder expression of implicated genes and pathways (n=50) and used symptom questionnaires for phenotyping. We conducted meta-analyses using inverse variance fixed effects models in METAL, and whole transcriptome analyses using Affymetrix arrays, with replication with TaqMan PCR.Results:In the discovery stage we identified 16 single nucleotide polymorphisms (SNPs) genotyped or imputed at five loci that reached genome-wide significance (p<5x10-8). In replication, rs138724718 on chromosome 2, near the macrophage receptor with collagenous structure (MARCO) gene (replication p=0.003) associated with stress incontinence. In addition, rs34998271 on chromosome 6 near the Endothelin 1 (EDN1) gene (replication p=0.0008) associated with urgency incontinence. In combined meta-analyses of discovery and replication cohorts, associations with genome-wide significance for these two SNPs were confirmed. Transcriptomics analyses showed differential expression of 7 of 19 genes in the endothelin pathway between stress and urgency incontinence (p<0.0001).Conclusion:We uncovered two new risk loci near the genes Endothelin 1 (EDN1), associated with urgency incontinence and Macrophage Receptor with Collagenous Structure (MARCO), associated with stress incontinence. These loci are biologically plausible given their roles in smooth muscle contraction and innate host defense respectively.
Karmarkar R, Digesu A, Fernando R, et al., 2021, Ultrasound assessment of urethral structure and bladder neck position in women with different parities, INTERNATIONAL UROGYNECOLOGY JOURNAL, ISSN: 0937-3462
Tailor VK, Morris E, Bhide AA, et al., 2020, Does cystoscopy method affect the investigation of bladder pain syndrome/interstitial cystitis?, INTERNATIONAL UROGYNECOLOGY JOURNAL, Vol: 32, Pages: 1229-1235, ISSN: 0937-3462
Derpapas A, Vijaya G, Nikolopoulos K, et al., 2020, The use of 3D ultrasound in comparing surgical techniques for posterior wall prolapse repair: a pilot randomised controlled trial, JOURNAL OF OBSTETRICS AND GYNAECOLOGY, Vol: 41, Pages: 594-600, ISSN: 0144-3615
McHayle A, Morris E, Bhide A, et al., 2020, External Anal Sphincter Thickness Measurements as an Independent Assessment of Patient Symptoms in Women following an Obstetric Anal Sphincter Injury, Publisher: SPRINGER LONDON LTD, Pages: 1720-1720, ISSN: 0937-3462
Tailor V, Morris E, Bhide A, et al., 2020, Does cystoscopy method affect the investigation of bladder pain?, Publisher: SPRINGER LONDON LTD, Pages: 1722-1723, ISSN: 0937-3462
Morris E, Tailor V, McHayle A, et al., 2020, The role of Diamine Oxidase in the pathophysiology and investigation of Bladder Pain Syndrome, Publisher: SPRINGER LONDON LTD, Pages: 1720-1721, ISSN: 0937-3462
Bhide A, Tailor V, Khullar V, 2020, Interstitial cystitis/bladder pain syndrome and recurrent urinary tract infection and the potential role of the urinary microbiome., Post Reproductive Health, Vol: 26, Pages: 87-90, ISSN: 2053-3705
Interstitial cystitis/bladder pain syndrome and recurrent urinary tract infections carry significant burden for those affected. As women enter the menopause, other factors may influence how these conditions manifest. The urinary microbiome has shown that the urine contains extensive numbers of bacteria. There is some evidence to suggest that it is altered depending on the menopausal state of the individual. It is possible that this alteration may go on to influence how the disease course of interstitial cystitis/bladder pain syndrome and recurrent urinary tract infections runs in the post-menopausal group. The review will explore these two conditions and the potential role of the urinary microbiome.
Tailor V, Gibbs K, Bhide A, et al., 2020, Does the symptom of bladder pain influence the urodynamic diagnosis?, Publisher: WILEY, Pages: E58-E58, ISSN: 1470-0328
Tailor V, Bhide A, Rahim A, et al., 2020, CYSTOSCOPIC RESECTION OF SQUAMOUS METAPLASIA TO TREAT RECURRENT URINARY TRACT INFECTIONS, Annual Meeting of the International-Continence-Society (ICS), Publisher: WILEY, Pages: S475-S475, ISSN: 0733-2467
Beattie-Spanjol S, Millar O, Tailor V, et al., 2020, IS ABNORMAL IMMUNOLOGY ASSOCIATED WITH RECURRENT URINARY TRACT INFECTIONS?, Annual Meeting of the International-Continence-Society (ICS), Publisher: WILEY, Pages: S450-S451, ISSN: 0733-2467
Kennelly M, Nitti V, Khullar V, et al., 2020, POST VOID RESIDUAL VOLUME AND RATES OF CLEAN INTERMITTENT CATHETERIZATION WITH SPONTANEOUS AND NON-SPONTANTEOUS VOIDING AFTER ONABOTULINUMTOXINA TREATMENT: POOLED ANALYSIS OF TWO PHASE 3 STUDIES, Annual Meeting of the International-Continence-Society (ICS), Publisher: WILEY, Pages: S210-S211, ISSN: 0733-2467
Millar O, Beattie-Spanjol S, Tailor V, et al., 2020, DO WE NEED TO BETTER ASSESS PAIN IN UROGYNAECOLOGY?, Annual Meeting of the International-Continence-Society (ICS), Publisher: WILEY, Pages: S259-S261, ISSN: 0733-2467
Karmarkar R, Digesu A, Fernando R, et al., 2020, Urethral sphincter volume and urodynamic diagnosis, INTERNATIONAL UROGYNECOLOGY JOURNAL, Vol: 31, Pages: 2589-2594, ISSN: 0937-3462
Glazener C, Breeman S, Elders A, et al., 2020, Mesh inlay, mesh kit or native tissue repair for women having repeat anterior or posterior prolapse surgery: randomised controlled trial (PROSPECT)., BJOG, Vol: 127, Pages: 1002-1013
OBJECTIVE: To compare standard (native tissue) repair with synthetic mesh inlays or mesh kits. DESIGN: Randomised controlled trial. SETTING: Thirty-three UK hospitals. POPULATION: Women having surgery for recurrent prolapse. METHODS: Women recruited using remote randomisation. MAIN OUTCOME MEASURES: Prolapse symptoms, condition-specific quality-of-life and serious adverse effects. RESULTS: A Mean Pelvic Organ Prolapse Symptom Score at 1 year was similar for each comparison (standard 6.6 versus mesh inlay 6.1, mean difference [MD] -0.41, 95% CI -2.92 to 2.11: standard 6.6 versus mesh kit 5.9, MD -1.21 , 95% CI -4.13 to 1.72) but the confidence intervals did not exclude a minimally important clinical difference. There was no evidence of difference in any other outcome measure at 1 or 2 years. Serious adverse events, excluding mesh exposure, were similar at 1 year (standard 7/55 [13%] versus mesh inlay 5/52 [10%], risk ratio [RR] 1.05 [0.66-1.68]: standard 3/25 [12%] versus mesh kit 3/46 [7%], RR 0.49 [0.11-2.16]). Cumulative mesh exposure rates over 2 years were 7/52 (13%) in the mesh inlay arm, of whom four women required surgical revision; and 4/46 in the mesh kit arm (9%), of whom two required surgical revision. CONCLUSIONS: We did not find evidence of a difference in terms of prolapse symptoms from the use of mesh inlays or mesh kits in women undergoing repeat prolapse surgery. Although the sample size was too small to be conclusive, the results provide a substantive contribution to future meta-analysis. TWEETABLE ABSTRACT: There is not enough evidence to support use of synthetic mesh inlay or mesh kits for repeat prolapse surgery.
Asfour V, Khullar V, Digesu GA, 2020, Complex extensive urethral diverticulum on pelvic floor ultrasound and MRI, International Urogynecology Journal and Pelvic Floor Dysfunction, Vol: 31, Pages: 2687-2689, ISSN: 0937-3462
A urethral diverticulum most commonly presents with recurrent urinary tract infection (51%), stress incontinence (45.5%), a vaginal lump (45%), urethral discharge (21%), and “the 3Ds” (dysuria, dyspareunia, post-void dribbling; 9%) . Diverticula are on average 26 mm in diameter (range 8–45 mm) , and are U-shaped or circumferential in 84% .
Asfour V, Digesu GA, Fernando R, et al., 2020, Ultrasound imaging of the perineal body: a useful clinical tool, International Urogynecology Journal and Pelvic Floor Dysfunction, Vol: 31, Pages: 1197-1202, ISSN: 0937-3462
Introduction and hypothesisThe perineal body is a fibromuscular pyramidal structure located between the vagina and the anus. It has been difficult to image because of its small size and anatomical location. This study used 2D transperineal ultrasound to measure the perineal body and assess whether there is an association with prolapse.MethodsAn observational, cross-sectional study was carried out in a tertiary level Urogynaecology department and included prolapse patients and healthy nulliparous volunteers (control group). This was a clinical assessment, including POP-Q and trans-perineal 2D ultrasound measurement of the perineal body height, length, perimeter, and area. Parametric tests were used, as the data were normally distributed. Results are reported as mean and 95% confidence interval (±95% CI).ResultsA total of 101 participants were recruited of which 22 were nulliparous healthy volunteers. Mean perineal body measurements in controls were height 22.5 ± 3.3 mm, length 17.4 ± 2.7 mm, perimeter 7.5 ± 0.9 mm, and area 2.8 ± 0.38 cm2. Perineal body measurements in 79 prolapse patients: height 16.9 ± 1.7 mm, length 16.0 ± 1.4 mm, perimeter 6.5 ± 0.5 mm and area 2.1 ± 0.5 cm2. A small perineal body was strongly associated with posterior compartment prolapse (paired t test, p < 0.0001) and wider POP-Q GH (paired t test, p = 0.0003). Surprisingly, Pelvic Organ Prolapse Quantification Perineal Body (POP-Q PB) of the two groups was not significantly different. A perineal body mid-sagittal area of less than 2.4 cm2 has been shown to be associated strongly with posterior compartment prolapse.ConclusionsIt is possible to measure the perineal body on 2D ultrasound. This technique facilitates the objective diagnosis of perineal deficiency. POP-Q PB does not predict the length or area of the perineal body.
Tailor VK, Bhide AA, Fernando R, et al., 2020, Does size matter? Perineometer and digital examination of a model levator hiatus, NEUROUROLOGY AND URODYNAMICS, Vol: 39, Pages: 1338-1344, ISSN: 0733-2467
Bhide AA, Tailor V, Fernando R, et al., 2020, Posterior tibial nerve stimulation for overactive bladder-techniques and efficacy, International Urogynecology Journal and Pelvic Floor Dysfunction, Vol: 31, Pages: 865-870, ISSN: 0937-3462
The ideal treatment for overactive bladder is still elusive. In those where medication fails to improve symptoms options include invasive treatments such as botulinum toxin-A, sacral neural stimulation or posterior tibial nerve stimulation. Scientific professional society guidelines advise percutaneous posterior tibial nerve stimulation as a third line treatment option only after multi-disciplinary team review as well as failure of both conservative and pharmacological management. The aim of this article is to review all techniques for tibial nerve stimulation and their efficacy.
Digesu GA, Tailor V, Bhide AA, et al., 2020, The role of bladder instillation in the treatment of bladder pain syndrome: Is intravesical treatment an effective option for patients with bladder pain as well as LUTS?, International Urogynecology Journal and Pelvic Floor Dysfunction, Vol: 31, Pages: 1387-1392, ISSN: 0937-3462
The aetiology of bladder pain syndrome/interstitial cystitis is still unknown. Numerous mechanisms have been proposed and treatments targeting various aspects of these are used. This review looks at the existing evidence on bladder instillations and whether they could be used in the treatment of lower urinary tract symptoms as well.
Khullar V, Rahnama'i MS, Veit-Rubin N, et al., 2020, Can we harness the placebo effect to improve care in lower urinary tract dysfunction? ICI-RS 2019, NEUROUROLOGY AND URODYNAMICS, Vol: 39, Pages: S80-S87, ISSN: 0733-2467
Kennelly M, Nitti V, Khullar V, et al., 2020, POST VOID RESIDUAL VOLUME AND RATES OF CLEAN INTERMITTENT CATHETERIZATION WITH SPONTANEOUS AND NON-SPONTANEOUS VOIDING AFTER ONABOTULINUMTOXINA TREATMENT, Annual Meeting of the American-Urological-Association (AUA), Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: E477-E477, ISSN: 0022-5347
Kennelly MJ, Nitti V, Khullar V, et al., 2020, post void residual volume and rates of clean intermittent catheterization with spontaneous and non-spontaneous voiding after onabotulinumtoxina treatment: pooled analysis of two phase 3 studies, Winter Meeting of the Society-for-Urodynamics-Female-Pelvic-Medicine-and-Urogenital-Reconstruction (SUFU), Publisher: WILEY, Pages: S159-S160, ISSN: 0733-2467
Rantell A, Veit-Rubin N, Giarenis I, et al., 2019, Recommendations and future research initiative to optimize bladder management in pregnancy and childbirth International Consultation on Incontinence - Research society 2018, NEUROUROLOGY AND URODYNAMICS, Vol: 38, Pages: S104-S110, ISSN: 0733-2467
Khullar V, Digesu GA, Veit-Rubin N, et al., 2019, How can we improve the diagnosis and management of bladder pain syndrome? Part 2:ICI-RS 2018, NEUROUROLOGY AND URODYNAMICS, Vol: 38, Pages: S71-S81, ISSN: 0733-2467
Khullar V, Chermansky C, Tarcan T, et al., 2019, How can we improve the diagnosis and management of bladder pain syndrome? Part 1: ICI-RS 2018, NEUROUROLOGY AND URODYNAMICS, Vol: 38, Pages: S66-S70, ISSN: 0733-2467
Ford AA, Tailor V, Ogah J, et al., 2019, Midurethral slings for treatment of stress urinary incontinence review (vol 38, pg S70, 2019), NEUROUROLOGY AND URODYNAMICS, Vol: 38, Pages: 2387-2387, ISSN: 0733-2467
Tailor V, Bhide AA, Patel M, et al., 2019, DOES THE SYMPTOM OF BLADDER PAIN INFLUENCE THE URODYNAMIC DIAGNOSIS?, Publisher: SPRINGER LONDON LTD, Pages: S297-S297, ISSN: 0937-3462
Karram MM, Khullar V, Hershorn S, et al., 2019, CHARACTERISTICS OF POST VOID RESIDUAL VOLUME FOLLOWING TREATMENT WITH ONABOTULINUMTOXINA FOR OVERACTIVE BLADDER: POOLED POST-HOC ANALYSIS IN A FEMALE SUBPOPULATION, Publisher: SPRINGER LONDON LTD, Pages: S92-S92, ISSN: 0937-3462
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