Publications
511 results found
Derpapas A, Khullar V, 2017, Perineal pelvic floor ultrasound: Applications and literature review, Practical Pelvic Floor Ultrasonography: A Multicompartmental Approach to 2D/3D/4D Ultrasonography of the Pelvic Floor: Second Edition, Pages: 79-100, ISBN: 9783319529288
Miotla P, Cartwright R, Franklin-Nembhard L, et al., 2017, Urinary endothelin and endothelin pathway gene expression in overactive bladder, EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, Vol: 211, Pages: 205-205, ISSN: 0301-2115
Khullar V, Anding R, Robinson D, et al., 2017, Under what circumstances should stress incontinence surgery be performed at the same time as prolapse surgery? ICI-RS 2015, NEUROUROLOGY AND URODYNAMICS, Vol: 36, Pages: 909-914, ISSN: 0733-2467
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- Citations: 6
Rantell A, Cardozo L, Khullar V, 2017, Personal goals and expectations of OAB patients in the UK, NEUROUROLOGY AND URODYNAMICS, Vol: 36, Pages: 1194-1200, ISSN: 0733-2467
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- Citations: 6
Bray R, Hendicken C, Ford A, et al., 2017, Should our approach to continence surgery differ depending on ethnicity?, EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, Vol: 211, Pages: 204-204, ISSN: 0301-2115
Bray R, Cartwright R, Digesu A, et al., 2017, A randomised controlled trial comparing immediate versus delayed catheter removal following vaginal prolapse surgery, EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, Vol: 210, Pages: 314-318, ISSN: 0301-2115
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- Citations: 13
Digesu GA, Gargasole C, Hendricken C, et al., 2017, ICS Teaching Module: Ambulatory Urodynamic Monitoring, NEUROUROLOGY AND URODYNAMICS, Vol: 36, Pages: 364-367, ISSN: 0733-2467
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- Citations: 4
Bray R, Cartwright R, Digesu A, et al., 2017, A randomised controlled trial comparing immediate versus delayed catheter removal following vaginal prolapse surgery, European Journal of Obstetrics and Gynecology and Reproductive Biology, ISSN: 0028-2243
OBJECTIVE: It is unclear if any catheterisation is necessary after vaginal surgery for pelvic organ prolapse. The aim of this study was to determine if indwelling catheterisation is necessary after these procedures. STUDY DESIGN: A randomised controlled trial of immediate post-operative removal of catheter compared to a suprapubic catheter (SPC) after vaginal prolapse surgery. In the Suprapubic group the catheter was left on free drainage until a voiding trial was commenced at 48hrs. Women in the immediate removal group underwent in/out catheterisation only if they had not voided by 8hrs after surgery to ensure the bladder did not over-distend. RESULTS: 55% (n=17) of patients in the immediate removal group did not require catheterisation postoperatively. A further 13 (42%) patients only required one in/out catheterisation 8 hours post operatively. In the immediate removal group duration of catheterisation was significantly shorter (median 0hrs, IQR 0-8 hours, range 0-16 hours) vs (6 days (IQR 2-8 days, range 2-19 hours) p=0.001). The duration of hospital stay (7 days (range 3-16) vs. 9 (range 3-27) p=0.014), day of first mobilisation (Day 1, range 0-2, vs. Day 2, range 1-4, p=0.001), and rate of Symptomatic bacturia (16% vs. 52%, p<0.01) were all significantly better with immediate catheter removal. CONCLUSIONS: After vaginal surgery for pelvic organ prolapse, the majority of patients do not require extended catheterisation. Early removal of a catheter reduces urinary tract infection and significantly decreases hospital stay. Such a policy should result in improved patient satisfaction and reduced hospital costs.
Vijaya G, Cartwright R, Bhide A, et al., 2016, Reliability and validity of urinary nerve growth factor measurement in women with lower urinary tract symptoms, NEUROUROLOGY AND URODYNAMICS, Vol: 35, Pages: 944-948, ISSN: 0733-2467
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- Citations: 9
Veit-Rubin N, Cartwright R, Singh AU, et al., 2016, Association between joint hypermobility and pelvic organ prolapse in women: a systematic review and meta-analysis, Publisher: SPRINGER LONDON LTD, Pages: 1469-1478, ISSN: 0937-3462
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- Citations: 18
Bray R, Derpapas A, Fernando R, et al., 2016, Does the vaginal wall thin as prolapse increases?, International Urogynecology Journal, Vol: 28, Pages: 397-402, ISSN: 1433-3023
Introduction and hypothesisThe pathophysiology of prolapse is not well understood. However, two main theories predominate: either the fibromuscular layer of the vagina develops a defect/tears away from its supports, or its tissues are stretched and attenuated. The aim of this study was to assess how vaginal wall thickness (VWT) is related to vaginal prolapse.MethodsThe study group comprised 243 women with symptomatic prolapse recruited from the Outpatient Department of a tertiary referral centre for urogynaecology. A history was taken and women were examined to determine their POP-Q score. Using a previously validated technique, ultrasonography was used to measure the mean VWT at three anatomical sites on the anterior and posterior walls. Scores were then compared using t tests, the Kruskal-Wallis test and the Friedman test.ResultsThe mean age of the patients was 59.7 years (SD 12.0 years range 38 – 84 years). For each measurement VWT reduced as prolapse grade increased until the prolapse extended beyond the hymen. Women with grade 3 prolapse had a significantly higher mean VWT than women with grade 1 or 2 contained prolapse. Menopause status did not have a significant effect on the VWT.ConclusionsVWT is lower in women with vaginal prolapse until the prolapse extends beyond the hymen and then VWT is thicker and comparable with women without prolapse. This may be explained by changes in the vaginal tissue including reduction of collagen, elastin and smooth muscle, as well as fibrosis in exposed tissues, rather than by defects in the vagina.
Robinson D, Oelke M, Khullar V, et al., 2016, Bladder wall thickness in women with symptoms of overactive bladder and detrusor overactivity: Results from the randomised, placebo-controlled shrink study, NEUROUROLOGY AND URODYNAMICS, Vol: 35, Pages: 819-825, ISSN: 0733-2467
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- Citations: 12
Nitti VW, Ginsberg D, Sievert K-D, et al., 2016, Durable Efficacy and Safety of Long-Term OnabotulinumtoxinA Treatment in Patients with Overactive Bladder Syndrome: Final Results of a 3.5-Year Study., J Urol, Vol: 196, Pages: 791-800
PURPOSE: These are the final results of the prospective, multicenter, long-term (3.5-year) study of the efficacy/safety of onabotulinumtoxinA for overactive bladder syndrome. MATERIALS AND METHODS: Patients who completed either of 2, 24-week phase 3 trials could enter a 3-year extension and continue treatment with onabotulinumtoxinA 100 U as needed to control overactive bladder symptoms. Data were analyzed by the treatment(s) received (up to 6) and in discrete subgroups that received 1, 2, 3, 4, 5 or 6 treatments (to evaluate the consistency of the response after repeat treatments in the same patient groups). Assessments included the change from baseline in the number of urinary incontinence episodes per day and the proportion of patients who reported improvement/great improvement in urinary symptoms on the TBS (Treatment Benefit Scale) at week 12 as co-primary end points. Other end points were the change from baseline in I-QOL (Incontinence Quality of Life), the number of urgency and micturition episodes per day; duration of effect; the number of adverse events; and the initiation of intermittent catheterization. RESULTS: Consistent mean reductions in urinary incontinence were observed following continued onabotulinumtoxinA treatment, ranging from -3.1 to -3.8 in the overall population and -2.9 to -4.5 in the discrete subgroups. Durable improvements were seen in overactive bladder symptoms and quality of life. A high proportion of patients rated their condition as improved/greatly improved. The median duration of effect was 7.6 months. The most common adverse event was urinary tract infection. The rate of de novo catheterization after the first treatment was 4.0% and it ranged from 0.6% to 1.7% after subsequent treatments. CONCLUSIONS: Long-term onabotulinumtoxinA treatment consistently decreased overactive bladder symptoms and improved quality of life with no new safety signals.
Veit-Rubin N, Cartwright R, Purwar B, et al., 2016, THE AS SOCIATION BETWEEN JOINT HYPERMOBILITY AND URINARY INCONTINENCE IN WOMEN: A SYSTEMATIC REVIEW AND META-ANALYSIS, International Urogynaecology Association Meeting, Publisher: SPRINGER LONDON LTD, Pages: S88-S89, ISSN: 0937-3462
Ford A, Bray R, Fernando R, et al., 2016, DEFICIENCY OF MANNOSE BINDING LECTIN AND DIAMINE OXIDASE AND A PREDISPOSITION TO RECURRENT URINARY TRACT INFECTIONS IN WOMEN, Annual Meeting of the International-Continence-Society (ICS), Publisher: WILEY-BLACKWELL, Pages: S279-S280, ISSN: 0733-2467
Ford AA, Bray R, Purwar B, et al., 2016, MANNOSE BINDING LECTIN AND A PREDISPOSITION TO RECURRENT URINARY TRACT INFECTIONS IN WOMEN, Publisher: SPRINGER LONDON LTD, Pages: S41-S42, ISSN: 0937-3462
Khullar V, Kaufmann A, Ginsberg D, et al., 2016, CONSISTENT AND DURABLE IMPROVEMENTS IN QUALITY OF LIFE WITH LONG-TERM ON ABOTULINUMTOXINA TREATMENT IN PATIENTS WITH OVERACTIVE BLADDER, Publisher: SPRINGER LONDON LTD, Pages: S27-S27, ISSN: 0937-3462
Ford AA, Grahame R, Seneviratne S, et al., 2016, DIAMINE OXIDASE AS A TEST FOR HISTAMINE INTOLERANCE IN THE PATHOGENESIS OF BLADDER PAIN SYNDROME, Publisher: SPRINGER LONDON LTD, Pages: S134-S135, ISSN: 0937-3462
Bray R, Ford AA, Purwar B, et al., 2016, DOES THE VAGINAL WALL THIN AS PROLAPSE INCREASES?, Publisher: SPRINGER LONDON LTD, Pages: S130-S131, ISSN: 0937-3462
Veit-Rubin N, Cartwright R, Rahmanou P, et al., 2016, EPIDEMIOLOGY, DIAGNOSIS, PROGNOSIS AND MANAGEMENT OF BLADDER TUMOUR IN NEURO-UROLOGICAL PATIENTS: A SYSTEMATIC REVIEW OF THE LITERATURE, NEUROUROLOGY AND URODYNAMICS, Vol: 35, Pages: S162-S163, ISSN: 0733-2467
Veit-Rubin N, Cartwright R, Purwar B, et al., 2016, CURRENT PERCEPTION THRESHOLDS OF PERINEAL AFFERENTS IN WOMEN WITH LOWER URINARY TRACT SYMPTOMS, NEUROUROLOGY AND URODYNAMICS, Vol: 35, Pages: S87-S88, ISSN: 0733-2467
Cavalcanti G, Bray R, Ford A, et al., 2016, CLINICAL AND URODYNAMIC FEATURES ASSOCIATED WITH DETRUSOR OVERACTIVITY IN WOMEN WITH LOWER URINARY TRACT SYMPTOMS, NEUROUROLOGY AND URODYNAMICS, Vol: 35, Pages: S219-S220, ISSN: 0733-2467
Da Silva AS, Digesu GA, Dell'Utri C, et al., 2016, Do ultrasound findings of levator ani "avulsion" correlate with anatomical findings: A multicenter cadaveric study, NEUROUROLOGY AND URODYNAMICS, Vol: 35, Pages: 683-688, ISSN: 0733-2467
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- Citations: 11
Rzepka J, Zalewski K, Stefanowicz A, et al., 2016, Validation of the Polish version of P-QoL questionnaire, GINEKOLOGIA POLSKA, Vol: 87, Pages: 477-483, ISSN: 0017-0011
Objective: Pelvic organ prolapse (POP) is a common morbidity that affects many women and significantly decreases qualityof life. The severity and the impact of the prolapse on the quality of life are important parameters in the management andfollow-up of affected patients. The aim of this validation study was to validate the Polish version of the Prolapse Qualityof Life questionnaire (P-QoL).Material and methods: The P-QOL questionnaire was translated into Polish and administered to women recruited fromtwo gynecological outpatient clinics (n = 231). Both symptomatic and asymptomatic women were included in the studyand examined in supine position using the Pelvic Organ Prolapse Quantification System (POP-Q). The validity was assessedby comparing symptom scores and quality-of-life scores between symptomatic and asymptomatic women.Results: A total number of 154 symptomatic and 77 asymptomatic women were included. There was a strong correlationbetween severity of the disease based on physical findings (POP-Q scale) and the P-QoL scores in main prolapse quality-of-lifedomains. The overall scores for each life domain were significantly different between symptomatic and asymptomaticwomen (p < 0.001). All the questions regarding symptoms showed significant differences (p < 0.001) between both groups.Conclusions: The Polish version of P-QoL is a valid, reliable, and easily comprehensible instrument to assess quality of lifeand symptoms in Polish-speaking women suffering from urogenital prolapse.
Karmarkar R, Fernando R, Regan L, et al., 2016, Urethral sphincter volume and urodynamic diagnoses, Publisher: Wiley, Pages: S213-S214, ISSN: 1520-6777
Karmarkar R, Fernando R, Regan L, et al., 2016, Is the urethra more mobile in women with stress urinary incontinence?, Publisher: Wiley, Pages: S368-S369, ISSN: 1520-6777
Bray R, Cartwright R, Tikkinen K, et al., 2016, Post partum incontinence and its effect on lower urinary tract symptoms: 12-year follow-up of a population-based prospective cohort, BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, Vol: 123, Pages: 50-51, ISSN: 1470-0328
Purwar B, Veit-Rubin N, Khullar V, 2016, Urinary incontinence: Assessing quality of information on YouTube and Google, BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, Vol: 123, Pages: 181-182, ISSN: 1470-0328
Bray R, Fernando R, Khullar V, et al., 2016, Vaginal wall thickness is related to the degree of vaginal prolapse, BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, Vol: 123, Pages: 179-179, ISSN: 1470-0328
Bray R, Triolo M, Hendricken C, et al., 2016, Obesity and urodynamic diagnosis: Why are obese women incontinent?, BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, Vol: 123, Pages: 179-180, ISSN: 1470-0328
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