Imperial College London

ProfessorWendyBarclay

Faculty of MedicineDepartment of Infectious Disease

Action Medical Research Chair Virology. Head of Department
 
 
 
//

Contact

 

+44 (0)20 7594 5035w.barclay

 
 
//

Location

 

416Medical SchoolSt Mary's Campus

//

Summary

 

Summary

I joined Imperial College in May 2007, moving with my research group from the University of Reading where I had previously been based since 1995.  I had graduated in Natural Sciences from Cambridge University and had undertaken my PhD at the Common Cold Unit, Salisbury under the joint supervision of Dr David Tyrrell and Dr Fred Brown, studying the human immune response to rhinovirus.  I acquired molecular virology skills as a postdoctoral fellow first in the laboratories of Professor Jeff Almond at Reading and then working with Dr Peter Palese at the Mount Sinai School of Medicine, New York.

My expertise is in the field of respiratory viruses, in particular influenza viruses. My studies aim to understand the molecular and cellular basis of the pathogenesis, host range restrictions and transmissibility of influenza viruses. The approach includes the generation of recombinant viruses with defined mutations. This strategy has contributed to the production of novel influenza pandemic vaccines. In principle, the work employs the most appropriate virus strains and relevant cell or animal models. Primary influenza clinical strains are obtained through a long-standing collaboration with the Health Protection Agency, and viruses are studied on primary human airway cells and in ferrets.  Translational aspects include analysing mode of action and resistance mechanisms of antiviral compounds, and characterization of novel cell substrates and attenuated virus backbones for influenza vaccines.  The laboratory is funded by MRC, BBSRC, the Wellcome Trust and commercial bodies.

Featured Videos



The Delta variant: Why is it so dominant?
Vaccines: a double dose with Professor Brian Cox | The Royal Society
Women Luminaries - When Infections go viral

 

Publications

Journals

Frise R, Baillon L, Zhou J, et al., 2022, A self-amplifying RNA vaccine protects against SARS-CoV-2 (D614G) and Alpha variant of concern (B.1.1.7) in a transmission-challenge hamster model., Vaccine, Vol:40, Pages:2848-2855

Chadeau-Hyam M, Wang H, Eales O, et al., 2022, SARS-CoV-2 infection and vaccine effectiveness in England (REACT-1): a series of cross-sectional random community surveys, The Lancet Respiratory Medicine, Vol:10, ISSN:2213-2600, Pages:355-366

Närhi F, Moonesinghe SR, Shenkin SD, et al., 2022, Implementation of corticosteroids in treatment of COVID-19 in the ISARIC WHO Clinical Characterisation Protocol UK: prospective, cohort study., The Lancet Digital Health, Vol:4, ISSN:2589-7500, Pages:e220-e234

Killingley B, Mann AJ, Kalinova M, et al., 2022, Safety, tolerability and viral kinetics during SARS-CoV-2 human challenge in young adults, Nature Medicine, ISSN:1078-8956, Pages:1-27

More Publications