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@article{Drake:2021:10.1016/S0140-6736(21)00799-6,
author = {Drake, TM and Riad, AM and Fairfield, CJ and Egan, C and Knight, SR and Pius, R and Hardwick, HE and Norman, L and Shaw, CA and McLean, KA and Thompson, AAR and Ho, A and Swann, OV and Sullivan, M and Soares, F and Holden, KA and Merson, L and Plotkin, D and Sigfrid, L and de, Silva TI and Girvan, M and Jackson, C and Russell, CD and Dunning, J and Solomon, T and Carson, G and Olliaro, P and Nguyen-Van-Tam, JS and Turtle, L and Docherty, AB and Openshaw, PJ and Baillie, JK and Harrison, EM and Semple, MG and ISARIC4C, investigators},
doi = {10.1016/S0140-6736(21)00799-6},
journal = {The Lancet},
pages = {223--237},
title = {Characterisation of in-hospital complications associated with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol UK: a prospective, multicentre cohort study},
url = {http://dx.doi.org/10.1016/S0140-6736(21)00799-6},
volume = {398},
year = {2021}
}

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TY  - JOUR
AB  - BACKGROUND: COVID-19 is a multisystem disease and patients who survive might have in-hospital complications. These complications are likely to have important short-term and long-term consequences for patients, health-care utilisation, health-care system preparedness, and society amidst the ongoing COVID-19 pandemic. Our aim was to characterise the extent and effect of COVID-19 complications, particularly in those who survive, using the International Severe Acute Respiratory and Emerging Infections Consortium WHO Clinical Characterisation Protocol UK. METHODS: We did a prospective, multicentre cohort study in 302 UK health-care facilities. Adult patients aged 19 years or older, with confirmed or highly suspected SARS-CoV-2 infection leading to COVID-19 were included in the study. The primary outcome of this study was the incidence of in-hospital complications, defined as organ-specific diagnoses occurring alone or in addition to any hallmarks of COVID-19 illness. We used multilevel logistic regression and survival models to explore associations between these outcomes and in-hospital complications, age, and pre-existing comorbidities. FINDINGS: Between Jan 17 and Aug 4, 2020, 80388 patients were included in the study. Of the patients admitted to hospital for management of COVID-19, 49·7% (36367 of 73197) had at least one complication. The mean age of our cohort was 71·1 years (SD 18·7), with 56·0% (41025 of 73197) being male and 81·0% (59289 of 73197) having at least one comorbidity. Males and those aged older than 60 years were most likely to have a complication (aged ≥60 years: 54·5% [16579 of 30416] in males and 48·2% [11707 of 24288] in females; aged <60 years: 48·8% [5179 of 10609] in males and 36·6% [2814 of 7689] in females). Renal (24·3%, 17752 of 73197), complex respiratory (18·4%, 13486 of 73197), and systemic (16·3%, 11895 of 73197) complications were
AU  - Drake,TM
AU  - Riad,AM
AU  - Fairfield,CJ
AU  - Egan,C
AU  - Knight,SR
AU  - Pius,R
AU  - Hardwick,HE
AU  - Norman,L
AU  - Shaw,CA
AU  - McLean,KA
AU  - Thompson,AAR
AU  - Ho,A
AU  - Swann,OV
AU  - Sullivan,M
AU  - Soares,F
AU  - Holden,KA
AU  - Merson,L
AU  - Plotkin,D
AU  - Sigfrid,L
AU  - de,Silva TI
AU  - Girvan,M
AU  - Jackson,C
AU  - Russell,CD
AU  - Dunning,J
AU  - Solomon,T
AU  - Carson,G
AU  - Olliaro,P
AU  - Nguyen-Van-Tam,JS
AU  - Turtle,L
AU  - Docherty,AB
AU  - Openshaw,PJ
AU  - Baillie,JK
AU  - Harrison,EM
AU  - Semple,MG
AU  - ISARIC4C,investigators
DO  - 10.1016/S0140-6736(21)00799-6
EP  - 237
PY  - 2021///
SN  - 0140-6736
SP  - 223
TI  - Characterisation of in-hospital complications associated with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol UK: a prospective, multicentre cohort study
T2  - The Lancet
UR  - http://dx.doi.org/10.1016/S0140-6736(21)00799-6
UR  - https://www.ncbi.nlm.nih.gov/pubmed/34274064
UR  - http://hdl.handle.net/10044/1/90609
VL  - 398
ER  -

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