Imperial College London
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ProfessorWendyBarclay

Faculty of Medicine, Department of Infectious Disease

Action Medical Research Chair Virology. Head of Department
 
 
 
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Contact

 

+44 (0)20 7594 5035w.barclay

 
 
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Location

 

416Medical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@unpublished{Chadeau-Hyam:2022,
author = {Chadeau-Hyam, M and Tang, D and Eales, O and Bodinier, B and Wang, H and Jonnerby, J and Whitaker, M and Elliott, J and Haw, D and Walters, C and Atchison, C and Diggle, P and Page, A and Ashby, D and Barclay, W and Taylor, G and Cooke, G and Ward, H and Darzi, A and Donnelly, C and Elliott, P},
title = {The Omicron SARS-CoV-2 epidemic in England during February 2022},
url = {http://hdl.handle.net/10044/1/95323},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - UNPB
AB  - Background The third wave of COVID-19 in England peaked in January 2022 resulting fromthe rapid transmission of the Omicron variant. However, rates of hospitalisations and deathswere substantially lower than in the first and second wavesMethods In the REal-time Assessment of Community Transmission-1 (REACT-1) study weobtained data from a random sample of 94,950 participants with valid throat and nose swabresults by RT-PCR during round 18 (8 February to 1 March 2022).Findings We estimated a weighted mean SARS-CoV-2 prevalence of 2.88% (95% credibleinterval [CrI] 2.76–3.00), with a within-round reproduction number (R) overall of 0.94 (0·91–0.96). While within-round weighted prevalence fell among children (aged 5 to 17 years) andadults aged 18 to 54 years, we observed a level or increasing weighted prevalence amongthose aged 55 years and older with an R of 1.04 (1.00–1.09). Among 1,195 positive sampleswith sublineages determined, only one (0.1% [0.0–0.5]) corresponded to AY.39 Deltasublineage and the remainder were Omicron: N=390, 32.7% (30.0–35.4) were BA.1; N=473,39.6% (36.8–42.5) were BA.1.1; and N=331, 27.7% (25.2–30.4) were BA.2. We estimated anR additive advantage for BA.2 (vs BA.1 or BA.1.1) of 0.40 (0.36–0.43). The highest proportionof BA.2 among positives was found in London.Interpretation In February 2022, infection prevalence in England remained high with levelor increasing rates of infection in older people and an uptick in hospitalisations. Ongoingsurveillance of both survey and hospitalisations data is required.Funding Department of Health and Social Care, England.
AU  - Chadeau-Hyam,M
AU  - Tang,D
AU  - Eales,O
AU  - Bodinier,B
AU  - Wang,H
AU  - Jonnerby,J
AU  - Whitaker,M
AU  - Elliott,J
AU  - Haw,D
AU  - Walters,C
AU  - Atchison,C
AU  - Diggle,P
AU  - Page,A
AU  - Ashby,D
AU  - Barclay,W
AU  - Taylor,G
AU  - Cooke,G
AU  - Ward,H
AU  - Darzi,A
AU  - Donnelly,C
AU  - Elliott,P
PY  - 2022///
TI  - The Omicron SARS-CoV-2 epidemic in England during February 2022
UR  - http://hdl.handle.net/10044/1/95323
ER  -
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