Imperial College London
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ProfessorWendyBarclay

Faculty of Medicine, Department of Infectious Disease

Action Medical Research Chair Virology. Head of Department
 
 
 
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Contact

 

+44 (0)20 7594 5035w.barclay

 
 
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Location

 

416Medical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Cordery:2022:10.1016/S2666-5247(22)00124-0,
author = {Cordery, R and Reeves, L and Zhou, J and Rowan, A and Watber, P and Rosadas, C and Crone, M and Storch, M and Freemont, P and Mosscrop, L and Cowley, A and Zelent, G and Bisset, K and Le, Blond H and Regmi, S and Buckingham, C and Junaideen, R and Abdulla, N and Eliahoo, J and Mindlin, M and Lamagni, T and Barclay, W and Taylor, GP and Sriskandan, S},
doi = {10.1016/S2666-5247(22)00124-0},
journal = {The Lancet Microbe},
pages = {e814--e823},
title = {Transmission of SARS-CoV-2 by children to contacts in schools and households: a prospective cohort and environmental sampling study in London},
url = {http://dx.doi.org/10.1016/S2666-5247(22)00124-0},
volume = {3},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background: Assessing transmission of SARS-CoV-2 by children in schools is of critical importance to inform public health action. We assessed frequency of acquisition of SARS-CoV-2 by contacts of pupils with COVID-19 in schools and households, and quantified SARS-CoV-2 shed into air and onto fomites in both settings.Methods: Incidents involving exposure to at least one index pupil with COVID-19 in 8 schools were identified between October 2020-July 2021 (prevailing variants, original, alpha and delta). Weekly PCR testing for SARS-CoV-2 was undertaken on immediate classroom contacts (the “bubble”), non-bubble school contacts, and household contacts of index pupils, supported by genome sequencing, and on surface and air samples from school and home environments.Findings: Secondary transmission of SARS-CoV-2 was not detected in 28 bubble contacts, representing 10 bubble classes (participation rate 8.8%, IQR 4.6-15.3%). Across 8 non-bubble classes, 3/62 pupils tested positive but these were unrelated to the original index case (participation rate 22.5%, IQR 9.7-32.3%). All three were asymptomatic and tested positive in one setting on the same day. In contrast, secondary transmission to previously-negative household contacts from infected index pupils was 17.1% (6/35) rising to 27.7% (13/47) when considering all potentialinfections in household contacts. Environmental contamination with SARS-CoV-2 was rare in schools; fomite SARS-CoV-2 was identified in 4/189 (2.1%) samples in bubble classrooms, 2/127 (1.6%) samples in non-bubble classrooms, and 5/130 (3.8%) samples in washrooms. This contrasted with fomites in households, where SARS-CoV-2 was identified in 60/248 (24.2%) bedroom samples, 66/241 (27.4%) communal room samples, and 21/188 (11.2%) bathroom samples. Air sampling identified SARS-CoV-2 RNA in just 1/68 (1.5%) of school air samples, compared with 21/85 (24.7%) of air samples taken in homes.Interpretation: There was no evidence of large scale SARS-Co
AU  - Cordery,R
AU  - Reeves,L
AU  - Zhou,J
AU  - Rowan,A
AU  - Watber,P
AU  - Rosadas,C
AU  - Crone,M
AU  - Storch,M
AU  - Freemont,P
AU  - Mosscrop,L
AU  - Cowley,A
AU  - Zelent,G
AU  - Bisset,K
AU  - Le,Blond H
AU  - Regmi,S
AU  - Buckingham,C
AU  - Junaideen,R
AU  - Abdulla,N
AU  - Eliahoo,J
AU  - Mindlin,M
AU  - Lamagni,T
AU  - Barclay,W
AU  - Taylor,GP
AU  - Sriskandan,S
DO  - 10.1016/S2666-5247(22)00124-0
EP  - 823
PY  - 2022///
SN  - 2666-5247
SP  - 814
TI  - Transmission of SARS-CoV-2 by children to contacts in schools and households: a prospective cohort and environmental sampling study in London
T2  - The Lancet Microbe
UR  - http://dx.doi.org/10.1016/S2666-5247(22)00124-0
UR  - http://hdl.handle.net/10044/1/96709
VL  - 3
ER  -
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