Professor William Cookson

Conrad DF, Keebler JEM, DePristo MA, Lindsay SJ, Zhang Y, Casals F, Idaghdour Y, Hartl CL, Torroja C, Garimella KV, Zilversmit M, Cartwright R, Rouleau GA, Daly M, Stone EA, Hurles ME, Awadalla Pet al., 2011, Variation in genome-wide mutation rates within and between human families, NATURE GENETICS, Vol: 43, Pages: 712-U137, ISSN: 1061-4036

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• Citations: 397

Ege M, Mayer M, Normand A, Genuneit J, Cookson W, Braun-Fahrlander C, Heederik D, Piarroux R, von Mutius E, Gabriela Set al., 2011, Exposure to environmental microorganisms and its inverse relation to childhood asthma, 30th Congress of the European-Academy-of-Allergy-and-Clinical-Immunology (EAACI), Publisher: WILEY-BLACKWELL, Pages: 57-57, ISSN: 0105-4538

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• Citations: 6

Freidin MB, Bhudia N, Lim E, Nicholson AG, Popat S, Cookson WO, Moffatt MFet al., 2011, SAMPLE HANDLING AND PROCESSING ARE CRITICAL FACTORS INFLUENCING THE RESULTS OF WHOLE GENOME GENE EXPRESSION PROFILING IN LUNG CANCER TISSUES, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: S373-S374, ISSN: 1556-0864

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Freidin MB, Nicholson AG, Lim E, Moffatt MF, Cookson WOet al., 2011, GLOBAL GENE EXPRESSION PROFILING TO IDENTIFY COMMON NETWORKS UNDERLYING LUNG CANCER AND SPECIFIC MARKERS OF DIFFERENT LUNG CANCER HISTOLOGICAL TYPES, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: S455-S455, ISSN: 1556-0864

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Cookson WOC, Moffatt MF, 2011, Genetics of complex airway disease., Proc Am Thorac Soc, Vol: 8, Pages: 149-153

The past 3 years have seen highly significant genetic effects identified for a wide variety of common complex diseases, including the airway disorders of asthma and chronic obstructive pulmonary disease. It appears that only a portion of the genetically mediated susceptibility to complex diseases has been identified, and there is much left to be discovered. This review briefly describes the results of the genome-wide association studies of asthma and gives an overview of the parallel and increasingly large-scale studies that are taking place with chronic obstructive pulmonary disease. The future impact is discussed of technological advances that allow increasingly large-scale gene expression studies, next-generation sequencing, and genome-wide testing for epigenetic effects. The use of genetic technology to examine the airway microbiota that interact with the mucosa in health and disease is described.

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Zhang M, Liang L, Morar N, Dixon A, Lathrop M, Abecasis G, Moffatt M, Cookson W, Kraft P, Qureshi A, Han Jet al., 2011, Integrating pathway analysis and genetics of gene expression for genome-wide association study on basal cell carcinoma, CANCER RESEARCH, Vol: 71, ISSN: 0008-5472

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Renz H, von Mutius E, Brandtzaeg P, Cookson WO, Autenrieth IB, Haller Det al., 2011, Gene-environment interactions in chronic inflammatory disease, NATURE IMMUNOLOGY, Vol: 12, Pages: 273-277, ISSN: 1529-2908

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• Citations: 122

Ege MJ, Mayer M, Normand A-C, Genuneit J, Cookson WOCM, Braun-Fahrlaender C, Heederik D, Piarroux R, von Mutius Eet al., 2011, Exposure to Environmental Microorganisms and Childhood Asthma, NEW ENGLAND JOURNAL OF MEDICINE, Vol: 364, Pages: 701-709, ISSN: 0028-4793

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• Citations: 1076

Holt RJ, Zhang Y, Binia A, Dixon AL, Vandiedonck C, Cookson WO, Knight JC, Moffatt MFet al., 2011, Allele-specific transcription of the asthma-associated PHD finger protein 11 gene (PHF11) modulated by octamer-binding transcription factor 1 (Oct-1)., Journal of Allergy and Clinical Immunology, Vol: 127, Pages: 1054-1062.e2, ISSN: 0091-6749

Asthma is a common, chronic inflammatory airway disease of major public health importance with multiple genetic determinants. Previously, we found by positional cloning that PHD finger protein 11 (PHF11) on chromosome 13q14 modifies serum immunoglobulin E (IgE) concentrations and asthma susceptibility. No coding variants in PHF11 were identified.ObjectiveHere we investigate the 3 single nucleotide polymorphisms (SNPs) in this gene most significantly associated with total serum IgE levels—rs3765526, rs9526569, and rs1046295—for a role in transcription factor binding.MethodsWe used electrophoretic mobility shift assays to examine the effect of the 3 SNPs on transcription factor binding in 3 cell lines relevant to asthma pathogenesis. Relative preferential expression of alleles was investigated by using the allelotyping method.ResultsElectrophoretic mobility shift assays show that rs1046295 modulates allele-specific binding by the octamer-binding transcription factor 1 (Oct-1). Analysis of the relative expression levels of the 2 alleles of this SNP in heterozygous individuals showed a modest, but highly significant (P = 6.5 × 10−16), preferential expression of the A allele consistent with a functional role for rs1046295.ConclusionThese results suggest a mechanism by which rs1046295 may act as a regulatory variant modulating transcription at this locus and altering asthma susceptibility.

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Mills RE, Walter K, Stewart C, Handsaker RE, Chen K, Alkan C, Abyzov A, Yoon SC, Ye K, Cheetham RK, Chinwalla A, Conrad DF, Fu Y, Grubert F, Hajirasouliha I, Hormozdiari F, Iakoucheva LM, Iqbal Z, Kang S, Kidd JM, Konkel MK, Korn J, Khurana E, Kural D, Lam HYK, Leng J, Li R, Li Y, Lin C-Y, Luo R, Mu XJ, Nemesh J, Peckham HE, Rausch T, Scally A, Shi X, Stromberg MP, Stuetz AM, Urban AE, Walker JA, Wu J, Zhang Y, Zhang ZD, Batzer MA, Ding L, Marth GT, McVean G, Sebat J, Snyder M, Wang J, Ye K, Eichler EE, Gerstein MB, Hurles ME, Lee C, McCarroll SA, Korbel JOet al., 2011, Mapping copy number variation by population-scale genome sequencing, NATURE, Vol: 470, Pages: 59-65, ISSN: 0028-0836

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• Citations: 792

Ege MJ, Strachan DP, Cookson WOCM, Moffatt MF, Gut I, Lathrop M, Kabesch M, Genuneit J, Buechele G, Sozanska B, Boznanski A, Cullinan P, Horak E, Bieli C, Braun-Fahrlaender C, Heederik D, von Mutius Eet al., 2011, Gene-environment interaction for childhood asthma and exposure to farming in Central Europe, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 127, Pages: 138-U226, ISSN: 0091-6749

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• Citations: 113

Molyneaux PL, Mallia P, Duff RM, Moffatt MF, Cookson WO, Johnston SLet al., 2011, Investigating The Role Of Rhinovirus Infection In Precipitating Bacterial Infections In COPD Using Culture Independent Molecular Microbiology, Publisher: AMER THORACIC SOC, ISSN: 1073-449X

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• Citations: 1

Wan YI, Shrine NRG, Soler-Artigas M, Wain LV, Moffatt MF, Bush A, Cookson WO, Strachan DP, Heaney L, Al-Momani BAH, Mansur AH, Manney S, Thomson NC, Chaudhuri R, Brightling CE, Bafadhel M, Singapuri A, Niven R, Simpson A, Holloway JW, Howarth PH, Hui J, Musk AW, James AL, Tobin MD, Sayers I, Hall IPet al., 2011, Comprehensive Evaluation Of Mild-To-Moderate Asthma Genes In Severe Asthma (AUGOSA), Publisher: AMER THORACIC SOC, ISSN: 1073-449X

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Wan YI, Soler-Artigas M, Shrine NRG, Wain LV, Tobin MD, Moffatt MF, Bush A, Cookson WO, Strachan D, Heaney L, Al-Momani BAH, Mansur AH, Manney S, Thomson N, Chaudhuri R, Brightling CE, Bafadhel M, Singapuri A, Niven R, Simpson A, Holloway JW, Howarth PH, Sayers I, Hall IPet al., 2011, Genome-Wide Association Study To Identify Genetic Determinants Of Severe Asthma (AUGOSA), Publisher: AMER THORACIC SOC, ISSN: 1073-449X

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• Citations: 1

Marth GT, Yu F, Indap AR, Garimella K, Gravel S, Leong WF, Tyler-Smith C, Bainbridge M, Blackwell T, Zheng-Bradley X, Chen Y, Challis D, Clarke L, Ball EV, Cibulskis K, Cooper DN, Fulton B, Hartl C, Koboldt D, Muzny D, Smith R, Sougnez C, Stewart C, Ward A, Yu J, Xue Y, Altshuler D, Bustamante CD, Clark AG, Daly M, DePristo M, Flicek P, Gabriel S, Mardis E, Palotie A, Gibbs Ret al., 2011, The functional spectrum of low-frequency coding variation, GENOME BIOLOGY, Vol: 12, ISSN: 1474-760X

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• Citations: 155

Thompson AR, Natanek SA, Willis-Owen SA, Cookson WO, Polkey MI, Moffatt MFet al., 2011, Gene Expression Profiling Of Quadriceps Femoris Muscle In COPD, Publisher: AMER THORACIC SOC, ISSN: 1073-449X

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Ding J, Gudjonsson JE, Liang L, Stuart PE, Li Y, Chen W, Weichenthal M, Ellinghaus E, Franke A, Cookson W, Nair RP, Elder JT, Abecasis GRet al., 2010, Gene Expression in Skin and Lymphoblastoid Cells: Refined Statistical Method Reveals Extensive Overlap in <i>cis</i>-eQTL Signals, AMERICAN JOURNAL OF HUMAN GENETICS, Vol: 87, Pages: 779-789, ISSN: 0002-9297

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• Citations: 144

Sudmant PH, Kitzman JO, Antonacci F, Alkan C, Malig M, Tsalenko A, Sampas N, Bruhn L, Shendure J, Eichler EE, Altshuler DL, Durbin RM, Abecasis GR, Bentley DR, Chakravarti A, Clark AG, Collins FS, De La Vega FM, Donnelly P, Egholm M, Flicek P, Gabriel SB, Gibbs RA, Knoppers BM, Lander ES, Lehrach H, Mardis ER, McVean GA, Nickerson DA, Peltonen L, Schafer AJ, Sherry ST, Wang J, Wilson RK, Deiros D, Metzker M, Muzny D, Reid J, Wheeler D, Li J, Jian M, Li G, Li R, Liang H, Tian G, Wang B, Wang W, Yang H, Zhang X, Zheng H, Ambrogio L, Bloom T, Cibulskis K, Fennell TJ, Jaffe DB, Shefler E, Sougnez CL, Gormley N, Humphray S, Kingsbury Z, Koko-Gonzales P, Stone J, McKernan KJ, Costa GL, Ichikawa JK, Lee CC, Sudbrak R, Borodina TA, Dahl A, Davydov AN, Marquardt P, Mertes F, Nietfeld W, Rosenstiel P, Schreiber S, Soldatov AV, Timmermann B, Tolzmann M, Affourtit J, Ashworth D, Attiya S, Bachorski M, Buglione E, Burke A, Caprio A, Celone C, Clark S, Conners D, Desany B, Gu L, Guccione L, Kao K, Kebbel A, Knowlton J, Labrecque M, McDade L, Mealmaker C, Minderman M, Nawrocki A, Niazi Fet al., 2010, Diversity of human copy number variation and multicopy genes, Science, Vol: 330, Pages: 641-646, ISSN: 0036-8075

Copy number variants affect both disease and normal phenotypic variation, but those lying within heavily duplicated, highly identical sequence have been difficult to assay. By analyzing short-read mapping depth for 159 human genomes, we demonstrated accurate estimation of absolute copy number for duplications as small as 1.9 kilobase pairs, ranging from 0 to 48 copies. We identified 4.1 million "singly unique nucleotide" positions informative in distinguishing specific copies and used them to genotype the copy and content of specific paralogs within highly duplicated gene families. These data identify human-specific expansions in genes associated with brain development, reveal extensive population genetic diversity, and detect signatures consistent with gene conversion in the human species. Our approach makes ∼1000 genes accessible to genetic studies of disease association.

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• Citations: 525

Altshuler D, Durbin RM, Abecasis GR, Bentley DR, Chakravarti A, Clark AG, Collins FS, De la Vega FM, Donnelly P, Egholm M, Flicek P, Gabriel SB, Gibbs RA, Knoppers BM, Lander ES, Lehrach H, Mardis ER, McVean GA, Nickerson D, Peltonen L, Schafer AJ, Sherry ST, Wang J, Wilson RK, Gibbs RA, Deiros D, Metzker M, Muzny D, Reid J, Wheeler D, Wang J, Li J, Jian M, Li G, Li R, Liang H, Tian G, Wang B, Wang J, Wang W, Yang H, Zhang X, Zheng H, Lander ES, Altshuler DL, Ambrogio L, Bloom T, Cibulskis K, Fennell TJ, Gabriel SB, Jaffe DB, Shefler E, Sougnez CL, Bentley DR, Gormley N, Humphray S, Kingsbury Z, Koko-Gonzales P, Stone J, McKernan KJ, Costa GL, Ichikawa JK, Lee CC, Sudbrak R, Lehrach H, Borodina TA, Dahl A, Davydov AN, Marquardt P, Mertes F, Nietfeld W, Rosenstiel P, Schreiber S, Soldatov AV, Timmermann B, Tolzmann M, Egholm M, Affourtit J, Ashworth D, Attiya S, Bachorski M, Buglione E, Burke A, Caprio A, Celone C, Clark S, Conners D, Desany B, Gu L, Guccione L, Kao K, Kebbel A, Knowlton J, Labrecque M, McDade L, Mealmaker C, Minderman M, Nawrocki A, Niazi F, Pareja K, Ramenani R, Riches D, Song W, Turcotte C, Wang S, Mardis ER, Dooling D, Fulton L, Fulton R, Weinstock G, Durbin RM, Burton J, Carter DM, Churcher C, Coffey A, Cox A, Palotie A, Quail M, Skelly T, Stalker J, Swerdlow HP, Turner D, De Witte A, Giles S, Gibbs RA, Wheeler D, Bainbridge M, Challis D, Sabo A, Yu F, Yu J, Wang J, Fang X, Guo X, Li R, Li Y, Luo R, Tai S, Wu H, Zheng H, Zheng X, Zhou Y, Yang H, Marth GT, Garrison EP, Huang W, Indap A, Kural D, Lee W-P, Leong WF, Huang W, Indap A, Kural D, Lee W-P, Leong WF, Quinlan AR, Stewart C, Stromberg MP, Ward AN, Wu J, Lee C, Mills RE, Shi X, Daly MJ, DePristo MA, Altshuler DL, Ball AD, Banks E, Bloom T, Browning BL, Cibulskis K, Fennell TJ, Garimella KV, Grossman SR, Handsaker RE, Hanna M, Hartl C, Jaffe DB, Kernytsky AM, Korn JM, Li H, Maguire JR, McCarroll SA, McKenna A, Nemesh JC, Philippakis AA, Poplin RE, Price A, Rivas MA, Sabeti PC, Schaffner SFet al., 2010, A map of human genome variation from population-scale sequencing, NATURE, Vol: 467, Pages: 1061-1073, ISSN: 0028-0836

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• Citations: 4415

Binia A, Khorasani N, Bhavsar PK, Adcock I, Brightling CE, Chung KF, Cookson WOC, Moffatt MFet al., 2010, Chromosome 17q21 SNP and severe asthma, Journal of Human Genetics, Vol: 56, Pages: 97-98, ISSN: 1435-232X

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DeWan AT, Triche EW, Xu X, Hsu L-I, Zhao C, Belanger K, Hellenbrand K, Willis-Owen SAG, Moffatt M, Cookson WOC, Himes BE, Weiss ST, Gauderman WJ, Baurley JW, Gilliland F, Wilk JB, O'Connor GT, Strachan DP, Hoh J, Bracken MBet al., 2010, <i>PDE11A</i> associations with asthma: Results of a genome-wide association scan, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 126, Pages: 871-U321, ISSN: 0091-6749

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• Citations: 39

Moffatt MF, Gut IG, Demenais F, Strachan DP, Bouzigon E, Heath S, von Mutius E, Farrall M, Lathrop M, Cookson WOCM, Kumar A, Burney P, Jarvis D, Wjst M, Kogevinas M, Jogi R, Janson C, Franklin KA, Omenaas E, Leynaert B, Pin I, Heinrich J, Probst-Hensch NM, Anto JM, Sunyer J, Maldonado J-A, Martinez-Moratalla J, Urrutia I, Payo F, Kauffmann F, Dizier M-H, Siroux V, Boznanski A, Braun-Fahrlaender C, Genuneit J, Glas J, Horak E, Kabesch M, Pillai SG, Helms PJ, Carlsen K, Carlsen K-H, Gerritsen J, Silverman M, Sly P, Tsanakas J, Von Berg A, Whyte M, Blumenthal M, Imboden M, Rochat T, Thun GA, Gerbase MW, Curjuric I, Gaspoz J-M, Liu L-JS, Wouters IM, Sigsgaard T, Heederik D, Basinas I, Schlunssen V, Omland O, Cullinan P, Vermeulen R, Henderson J, Granell R, McArdle WL, Smith GD, James AL, Hui J, Palmer LJ, Beilby J, Musk AW, Laprise C, Hudson TJ, Lemire M, Daley D, Becker A, Chan-Yeung M, Sandford A, Kozyrskyj AL, Pare P, Ferguson A, Dimich-Ward H, Watson WT, Freidin MB, Bragina EI, Deev IA, Deeva EV, Kobyakova OS, Puzyrev VP, Ogorodova LM, Khusnutdinova EK, Karunas AS, Fedorova YY, Hall IP, Sayers I, Tobin MD, Wan YI, Heaney LG, Al-Momani BAH, Mansur AH, Manney S, Thomson NC, Chaudhuri R, Brightling CE, Bafadhel M, Singapuri A, Niven R, Simpson A, Holloway JW, Howarth PH, Polonikov AV, Ivanov VP, Solodilova MA, Melen E, Pershagen G, Bergstroem A, Kull I, Nyberg F, Wickman M, Soderhall C, Kere J, Postma DS, Kerkhof M, Brunekreef B, Smit HA, de Jongste JC, Wijga A, Aalberse RC, Hoekstra MO, Koppelman GH, Binia A, Chung KF, Bhavsar P, Chow F, Macedo P, Menzies-Gow A, van Stiphout N, Bush A, Lee Y-A, Esparza-Gordillo J, Nickel R, Wahn U, Lau S, Marenholz I, Haahtela T, von Hertzen L, Jousilahti P, Laatikainen T, Makela MJ, Vartiainen E, Laitinen T, Balding DJ, Peden JF, Corda E, Lechner D, Besse C, Zelenika D, Boland A, Bacq D, Demonchy S, Blanche H, Kamatani Y, von Mutius E, Farrall M, Lathrop M, Cookson WOCMet al., 2010, A Large-Scale, Consortium-Based Genomewide Association Study of Asthma, NEW ENGLAND JOURNAL OF MEDICINE, Vol: 363, Pages: 1211-1221, ISSN: 0028-4793

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• Citations: 1474

Harper JI, Godwin H, Green A, Wilkes LE, Holden NJ, Moffatt M, Cookson WO, Layton G, Chandler Set al., 2010, A study of matrix metalloproteinase expression and activity in atopic dermatitis using a novel skin wash sampling assay for functional biomarker analysis, BRITISH JOURNAL OF DERMATOLOGY, Vol: 162, Pages: 397-403, ISSN: 0007-0963

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• Citations: 52

Mathias RA, Grant AV, Rafaels N, Hand T, Gao L, Vergara C, Tsai YJ, Yang M, Campbell M, Foster C, Gao P, Togias A, Hansel NN, Diette G, Adkinson NF, Liu MC, Faruque M, Dunston GM, Watson HR, Bracken MB, Hoh J, Maul P, Maul T, Jedlicka AE, Murray T, Hetmanski JB, Ashworth R, Ongaco CM, Hetrick KN, Doheny KF, Pugh EW, Rotimi CN, Ford J, Eng C, Burchard EG, Sleiman PMA, Hakonarson H, Forno E, Raby BA, Weiss ST, Scott AF, Kabesch M, Liang L, Abecasis G, Moffatt MF, Cookson WOC, Ruczinski I, Beaty TH, Barnes KCet al., 2010, A genome-wide association study on African-ancestry populations for asthma, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 125, Pages: 336-346, ISSN: 0091-6749

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• Citations: 140

Sleiman PMA, Flory J, Imielinski M, Bradfield JP, Annaiah K, Willis-Owen SAG, Wang K, Rafaels NM, Michel S, Bonnelykke K, Zhang H, Kim CE, Frackelton EC, Glessner JT, Hou C, Otieno FG, Santa E, Thomas K, Smith RM, Glaberson WR, Garris M, Chiavacci RM, Beaty TH, Ruczinski I, Orange JM, Allen J, Spergel JM, Grundmeier R, Mathias RA, Christie JD, von Mutius E, Cookson WOC, Kabesch M, Moffatt MF, Grunstein MM, Barnes KC, Devoto M, Magnusson M, Li H, Grant SFA, Bisgaard H, Hakonarson Het al., 2010, Variants of <i>DENND1B</i> Associated with Asthma in Children, NEW ENGLAND JOURNAL OF MEDICINE, Vol: 362, Pages: 36-44, ISSN: 0028-4793

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• Citations: 253

Hilty M, Burke C, Pedro H, Cardenas P, Bush A, Bossley C, Davies J, Ervine A, Poulter L, Pachter L, Moffatt MF, Cookson WOCet al., 2010, Disordered Microbial Communities in Asthmatic Airways, PLOS ONE, Vol: 5, ISSN: 1932-6203

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• Citations: 1171

Genuneit J, Cantelmo JL, Weinmayr G, Wong GWK, Cooper PJ, Riikjaerv M-A, Gotua M, Kabesch M, von Mutius E, Forastiere F, Crane J, Nystad W, El-Sharif N, Batlles-Garrido J, Garcia-Marcos L, Garcia-Hernandez G, Morales-Suarez-Varela M, Nilsson L, Braback L, Saraclar Y, Weiland SK, Cookson WOC, Strachan D, Moffatt MFet al., 2009, A multi-centre study of candidate genes for wheeze and allergy: the International Study of Asthma and Allergies in Childhood Phase 2, CLINICAL AND EXPERIMENTAL ALLERGY, Vol: 39, Pages: 1875-1888, ISSN: 0954-7894

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• Citations: 41

Taylor JM, Street TL, Hao L, Copley R, Taylor MS, Hayden PJ, Stolper G, Mott R, Hein J, Moffatt MF, Cookson WOCMet al., 2009, Dynamic and Physical Clustering of Gene Expression during Epidermal Barrier Formation in Differentiating Keratinocytes, PLOS ONE, Vol: 4, ISSN: 1932-6203

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• Citations: 26

Zhang Y, Cookson W, Moffatt M, 2009, Pharmacogenetics and Pharmacogenomics of Airway Diseases, Pharmacology and Therapeutics of Airway Disease, Editors: Barnes, Chung, Publisher: Taylor & Francis Group

I. Introduction Asthma and chronic obstructive pulmonary disease (COPD) are complex syndromes of airway inflammation. Asthma is a disease of the small airways of the lung. Intermittent narrowing of the respiratory bronchioles produces airway limitation and the symptoms of wheezing, chest tightness, and breathlessness. By contrast, in COPD the limitation of airflow is poorly reversible and usually gets progressively worse over time. The disease is primarily, but not exclusively, seen in smokers and former smokers. Environmental and genetic factors contribute to the etiology of both diseases. Cigarette smoking is the main risk factor for COPD, although less than 20% of chronic heavy smokers will develop symptoms of airway obstruction (1). Bronchodilators and corticosteroids are currently the most common medications used in the treatment of asthma and COPD.

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Himes BE, Hunninghake GM, Baurley JW, Rafaels NM, Sleiman P, Strachan DP, Wilk JB, Willis-Owen SAG, Klanderman B, Lasky-Su J, Lazarus R, Murphy AJ, Soto-Quiros ME, Avila L, Beaty T, Mathias RA, Ruczinski I, Barnes KC, Celedon JC, Cookson WOC, Gauderman WJ, Gilliland FD, Hakonarson H, Lange C, Moffatt MF, O'Connor GT, Raby BA, Silverman EK, Weiss STet al., 2009, Genome-wide Association Analysis Identifies <i>PDE4D</i> as an Asthma-Susceptibility Gene, AMERICAN JOURNAL OF HUMAN GENETICS, Vol: 84, Pages: 581-593, ISSN: 0002-9297

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• Citations: 248