Imperial College London
Portrait Picture

Professor William Cookson

Faculty of Medicine, National Heart & Lung Institute

Professor of Genomic Medicine
 
 
 
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Contact

 

+44 (0)20 7594 2943w.cookson

 
 
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Location

 

400Guy Scadding BuildingRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Hoang:2019:10.1002/1878-0261.12568,
author = {Hoang, LT and Domingo-Sabugo, C and Starren, ES and Willis-Owen, SA and Morris-Rosendah, DJ and Nicholson, AG and Cookson, WOCM and Moffatt, MF},
doi = {10.1002/1878-0261.12568},
journal = {Molecular Oncology},
pages = {2406--2421},
title = {Metabolomic, transcriptomic and genetic integrative analysis reveals important roles of adenosine diphosphate in haemostasis and platelet activation in non-small-cell lung cancer},
url = {http://dx.doi.org/10.1002/1878-0261.12568},
volume = {13},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Lung cancer is the leading cause of cancerrelated deaths in the world. The most prevalent subtype, accounting for 85% of cases, is nonsmallcell lung cancer (NSCLC). Lung squamous cell carcinoma (LUSC) and lung adenocarcinoma (LUAD) are the most common subtypes. Despite recent advances in treatment, the low 5year survival rate of NSCLC patients (approximately 13%) reflects the lack of early diagnostic biomarkers and incomplete understanding of the underlying disease mechanisms. We hypothesized that integration of metabolomic, transcriptomic and genetic profiles of tumours and matched normal tissues could help to identify important factors and potential therapeutic targets that contribute to tumorigenesis. We integrated omics profiles in tumours and matched adjacent normal tissues of patients with LUSC (N = 20) and LUAD (N = 17) using multiple system biology approaches. We confirmed the presence of previously described metabolic pathways in NSCLC, particularly those mediating the Warburg effect. In addition, through our combined omics analyses we found that metabolites and genes that contribute to haemostasis, angiogenesis, platelet activation and cell proliferation were predominant in both subtypes of NSCLC. The important roles of adenosine diphosphate in promoting cancer metastasis through platelet activation and angiogenesis suggest this metabolite could be a potential therapeutic target.
AU  - Hoang,LT
AU  - Domingo-Sabugo,C
AU  - Starren,ES
AU  - Willis-Owen,SA
AU  - Morris-Rosendah,DJ
AU  - Nicholson,AG
AU  - Cookson,WOCM
AU  - Moffatt,MF
DO  - 10.1002/1878-0261.12568
EP  - 2421
PY  - 2019///
SN  - 1574-7891
SP  - 2406
TI  - Metabolomic, transcriptomic and genetic integrative analysis reveals important roles of adenosine diphosphate in haemostasis and platelet activation in non-small-cell lung cancer
T2  - Molecular Oncology
UR  - http://dx.doi.org/10.1002/1878-0261.12568
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000488792700001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://febs.onlinelibrary.wiley.com/doi/full/10.1002/1878-0261.12568
UR  - http://hdl.handle.net/10044/1/75047
VL  - 13
ER  -
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