Imperial College London
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Professor William Cookson

Faculty of Medicine, National Heart & Lung Institute

Professor of Genomic Medicine
 
 
 
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Contact

 

+44 (0)20 7594 2943w.cookson

 
 
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Location

 

400Guy Scadding BuildingRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Ahmed:2021:10.1136/bmjresp-2021-001106,
author = {Ahmed, B and Cox, MJ and Cuthbertson, L and James, P and Gardner, L and Cookson, W and Davies, J and Moffatt, M and Bush, A},
doi = {10.1136/bmjresp-2021-001106},
journal = {BMJ Open Respiratory Research},
pages = {1--10},
title = {Comparison of the airway microbiota in children with chronic suppurative lung disease},
url = {http://dx.doi.org/10.1136/bmjresp-2021-001106},
volume = {8},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Rationale:The airway microbiota is important in chronic suppurative lung diseases (CSLD), such as primary ciliary dyskinesia (PCD) and cystic fibrosis (CF).  This comparison has not previously been described but is important because difference between the two diseases may relate to the differing prognoses and lead to pathological insights and potentially, new treatments. Objectives:To compare the longitudinal development of the airway microbiota in children with PCD to that of CF and relate this to age and clinical status. Methods:Sixty-two age-matched children (age range 0.5–17 years) with PCD or CF (n=31 in each group) were recruited prospectively and followed for 1.1 years.  Throat swabs or sputum as well as clinical information were collected at routine clinical appointments.  16S rRNA gene sequencing was performed.  Measurements and Main Results:The microbiota was highly individual and more diverse in PCD and differed in community composition when compared with CF.  Whilst Streptococcus was the most abundant genus in both conditions, Pseudomonas was more abundant in CF with Haemophilus more abundant in PCD (Padj=0.0005).  In PCD only, an inverse relationship was seen in the relative abundance of Streptococcus and Haemophilus with age. Conclusions:Bacterial community composition differs between children with PCD and those with CF. Pseudomonas is more prevalent in CF and Haemophilus in PCD, at least until infection with Pseudomonas supervenes.  Interactions between organisms, particularly members of Haemophilus, Streptococcus, and Pseudomonas genera appear important.  Study of the interactions between these organisms may lead to new therapies or risk stratification.
AU  - Ahmed,B
AU  - Cox,MJ
AU  - Cuthbertson,L
AU  - James,P
AU  - Gardner,L
AU  - Cookson,W
AU  - Davies,J
AU  - Moffatt,M
AU  - Bush,A
DO  - 10.1136/bmjresp-2021-001106
EP  - 10
PY  - 2021///
SN  - 2052-4439
SP  - 1
TI  - Comparison of the airway microbiota in children with chronic suppurative lung disease
T2  - BMJ Open Respiratory Research
UR  - http://dx.doi.org/10.1136/bmjresp-2021-001106
UR  - https://bmjopenrespres.bmj.com/content/8/1/e001106
UR  - http://hdl.handle.net/10044/1/93107
VL  - 8
ER  -
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