Imperial College London
Alternate

ProfessorWaljitDhillo

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Professor of Endocrinology & Metabolism
 
 
 
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Contact

 

+44 (0)20 7594 3487w.dhillo Website

 
 
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Assistant

 

Ms Suzanne Wheeler +44 (0)20 7594 3487

 
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Location

 

6N6ECommonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Comninos:2021:10.1016/j.psyneuen.2021.105244,
author = {Comninos, A and Yang, L and OCallaghan, J and Mills, E and Wall, M and Demetriou, L and Wing, V and Thurston, L and Owen, B and Abbara, A and Rabiner, E and Dhillo, W},
doi = {10.1016/j.psyneuen.2021.105244},
journal = {Psychoneuroendocrinology},
pages = {1--5},
title = {Kisspeptin modulates gamma-aminobutyric acid levels in the human brain},
url = {http://dx.doi.org/10.1016/j.psyneuen.2021.105244},
volume = {129},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Gamma-aminobutyric acid (GABA) is a key inhibitory neurotransmitter that has been implicated in the aetiology of common mood and behavioural disorders. By employing proton magnetic resonance spectroscopy in man, we demonstrate that administration of the reproductive neuropeptide, kisspeptin, robustly decreases GABA levels in the limbic system of the human brain; specifically the anterior cingulate cortex (ACC). This finding defines a novel kisspeptin-activated GABA pathway in man, and provides important mechanistic insights into the mood and behaviour-altering effects of kisspeptin seen in rodents and humans. In addition, this work has therapeutic implications as it identifies GABA-signalling as a potential target for the escalating development of kisspeptin-based therapies for common reproductive disorders of body and mind.
AU  - Comninos,A
AU  - Yang,L
AU  - OCallaghan,J
AU  - Mills,E
AU  - Wall,M
AU  - Demetriou,L
AU  - Wing,V
AU  - Thurston,L
AU  - Owen,B
AU  - Abbara,A
AU  - Rabiner,E
AU  - Dhillo,W
DO  - 10.1016/j.psyneuen.2021.105244
EP  - 5
PY  - 2021///
SN  - 0306-4530
SP  - 1
TI  - Kisspeptin modulates gamma-aminobutyric acid levels in the human brain
T2  - Psychoneuroendocrinology
UR  - http://dx.doi.org/10.1016/j.psyneuen.2021.105244
UR  - https://www.sciencedirect.com/science/article/pii/S0306453021001189?via%3Dihub
UR  - http://hdl.handle.net/10044/1/89399
VL  - 129
ER  -
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