Imperial College London
Alternate

ProfessorWaljitDhillo

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Professor of Endocrinology & Metabolism
 
 
 
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Contact

 

+44 (0)20 7594 3487w.dhillo Website

 
 
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Assistant

 

Ms Suzanne Wheeler +44 (0)20 7594 3487

 
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Location

 

6N6ECommonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Phylactou:2021:10.1016/j.fertnstert.2021.04.031,
author = {Phylactou, M and Abbara, A and Al-Memar, M and Kyriacou, C and Pei, Chia E and Nadir, R and Izzie-Engbeaya, C and Clarke, S and Mills, E and Daniels, E and Huo, L and Pacuszka, E and Yang, L and Patel, B and Tan, T and Bech, P and Comninos, A and Fourie, H and Kelsey, T and Bourne, T and Dhillo, W and Abbara, A},
doi = {10.1016/j.fertnstert.2021.04.031},
journal = {Fertility and Sterility},
pages = {809--819},
title = {Performance of plasma kisspeptin as a biomarker for miscarriage improves with gestation during the first trimester},
url = {http://dx.doi.org/10.1016/j.fertnstert.2021.04.031},
volume = {116},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - ObjectiveTo compare the performance of kisspeptin and beta human chorionic gonadotropin (βhCG), both alone and in combination, as biomarkers for miscarriage throughout the first trimester.DesignProspective, nested case-control study.SettingTertiary Centre, Queen Charlotte Hospital, London, United Kingdom.Patient(s)Adult women who had miscarriages (n = 95, 173 samples) and women with healthy pregnancies (n = 265, 557 samples).Intervention(s)The participants underwent serial ultrasound scans and blood sampling for measurement of plasma kisspeptin and βhCG levels during the first trimester.Main Outcome Measure(s)The ability of plasma kisspeptin and βhCG levels to distinguish pregnancies complicated by miscarriage from healthy pregnancies unaffected by miscarriage.Result(s)Gestation-adjusted levels of circulating kisspeptin and βhCG were lower in samples from women with miscarriages than in women with healthy pregnancies by 79% and 70%, respectively. The area under the receiver-operating characteristic curve for identifying miscarriage during the first trimester was 0.874 (95% confidence interval [CI] 0.844–0.904) for kisspeptin, 0.859 (95% CI 0.820–0.899) for βhCG, and 0.916 (95% CI 0.886–0.946) for the sum of the two markers. The performance of kisspeptin in identifying miscarriage improved with increasing length of gestation, whereas that of βhCG worsened. A decision matrix incorporating kisspeptin, βhCG, and gestational age had 83% to 87% accuracy for the prediction of miscarriage.Conclusion(s)Plasma kisspeptin is a promising biomarker for miscarriage and provides additional value to βhCG alone, especially during later gestational weeks of the first trimester.
AU  - Phylactou,M
AU  - Abbara,A
AU  - Al-Memar,M
AU  - Kyriacou,C
AU  - Pei,Chia E
AU  - Nadir,R
AU  - Izzie-Engbeaya,C
AU  - Clarke,S
AU  - Mills,E
AU  - Daniels,E
AU  - Huo,L
AU  - Pacuszka,E
AU  - Yang,L
AU  - Patel,B
AU  - Tan,T
AU  - Bech,P
AU  - Comninos,A
AU  - Fourie,H
AU  - Kelsey,T
AU  - Bourne,T
AU  - Dhillo,W
AU  - Abbara,A
DO  - 10.1016/j.fertnstert.2021.04.031
EP  - 819
PY  - 2021///
SN  - 0015-0282
SP  - 809
TI  - Performance of plasma kisspeptin as a biomarker for miscarriage improves with gestation during the first trimester
T2  - Fertility and Sterility
UR  - http://dx.doi.org/10.1016/j.fertnstert.2021.04.031
UR  - https://www.sciencedirect.com/science/article/pii/S0015028221003058?via%3Dihub
UR  - http://hdl.handle.net/10044/1/89400
VL  - 116
ER  -
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