Imperial College London
Alternate

ProfessorWaljitDhillo

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Professor of Endocrinology & Metabolism
 
 
 
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Contact

 

+44 (0)20 7594 3487w.dhillo Website

 
 
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Assistant

 

Ms Suzanne Wheeler +44 (0)20 7594 3487

 
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Location

 

6N6ECommonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Modi:2021:10.1016/B978-0-12-819975-6.00029-7,
author = {Modi, M and Dhillo, WS},
doi = {10.1016/B978-0-12-819975-6.00029-7},
journal = {Handb Clin Neurol},
pages = {455--460},
title = {The neuroendocrinology of the preoptic area in menopause: Symptoms and therapeutic strategies.},
url = {http://dx.doi.org/10.1016/B978-0-12-819975-6.00029-7},
volume = {179},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The preoptic area of the hypothalamus is the central hub of thermoregulation in mammals, coordinating autonomic heat-effector pathways in response to sensory information from the ambient and internal environment. This aims to maintain temperature homeostasis at a predetermined thermoregulatory set-point. However, hormonal and neuronal changes during the menopause, including estrogen deficiency, disrupt these normal thermoregulatory responses. This results in abnormal activation of heat dissipation effectors, manifesting clinically as hot flush symptoms. Neurokinin B (NKB) signaling via the neurokinin-3 receptor (NK3R) within the preoptic area is thought to play an important role in the pathophysiology of hot flushes. Therefore attenuation of the NKB/NK3R signaling pathway has garnered much interest as a novel therapeutic target for the amelioration of menopausal hot flushes. Recent clinical trials have demonstrated that NK3R antagonists can produce rapid and sustained improvements in hot flush frequency, severity, and quality of life, without the need for estrogen exposure. Therefore NK3R antagonists are fast emerging as a safe and efficacious alternative to hormone replacement therapy, the current gold standard of treatment.
AU  - Modi,M
AU  - Dhillo,WS
DO  - 10.1016/B978-0-12-819975-6.00029-7
EP  - 460
PY  - 2021///
SN  - 0072-9752
SP  - 455
TI  - The neuroendocrinology of the preoptic area in menopause: Symptoms and therapeutic strategies.
T2  - Handb Clin Neurol
UR  - http://dx.doi.org/10.1016/B978-0-12-819975-6.00029-7
UR  - https://www.ncbi.nlm.nih.gov/pubmed/34225982
VL  - 179
ER  -
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