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@article{Mills:2023:10.1001/jamanetworkopen.2022.54313,
author = {Mills, E and Ertl, N and Wall, M and Thurston, L and Yang, L and Suladze, S and Hunjan, T and Phylactou, M and Patel, B and Muzi, B and Ettehad, D and Bassett, P and Howard, J and Rabiner, E and Bech, P and Abbara, A and Goldmeier, D and Comninos, A and Dhillo, W},
doi = {10.1001/jamanetworkopen.2022.54313},
journal = {Jama Network Open},
pages = {1--16},
title = {Effects of kisspeptin on sexual brain processing and penile tumescence in men with hypoactive sexual desire disorder: a randomized clinical trial},
url = {http://dx.doi.org/10.1001/jamanetworkopen.2022.54313},
volume = {6},
year = {2023}
}

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TY  - JOUR
AB  - Importance  The human physiological sexual response is crucial for reward, satisfaction, and reproduction. Disruption of the associated neurophysiological pathways predisposes to low sexual desire; the most prevalent psychological form is hypoactive sexual desire disorder (HSDD), which affects 8% of men but currently has no effective pharmacological treatment options. The reproductive neuropeptide kisspeptin offers a putative therapeutic target, owing to emerging understanding of its role in reproductive behavior.Objective  To determine the physiological, behavioral, neural, and hormonal effects of kisspeptin administration in men with HSDD.Design, Setting, and Participants  This double-blind, 2-way crossover, placebo-controlled randomized clinical trial was performed at a single academic research center in the UK. Eligible participants were right-handed heterosexual men with HSDD. Physiological, behavioral, functional magnetic resonance imaging (fMRI), and hormonal analyses were used to investigate the clinical and mechanistic effects of kisspeptin administration in response to visual sexual stimuli (short and long video tasks). The trial was conducted between January 11 and September 15, 2021, and data analysis was performed between October and November 2021.Interventions  Participants attended 2 study visits at least 7 days apart, in balanced random order, for intravenous infusion of kisspeptin-54 (1 nmol/kg/h) for 75 minutes or for administration of a rate-matched placebo.Main Outcomes and Measures  Changes in (1) brain activity on whole-brain analysis, as determined by fMRI blood oxygen level–dependent activity in response to visual sexual stimuli during kisspeptin administration compared with placebo, (2) physiological sexual arousal (penile tumescence), and (3) behavioral measures of sexual desire and arousal.Results  Of the 37 men randomized, 32 completed the trial. Participants had a mean (SD) age of 37.9 (8.6) years and a mean (SD) body mass i
AU  - Mills,E
AU  - Ertl,N
AU  - Wall,M
AU  - Thurston,L
AU  - Yang,L
AU  - Suladze,S
AU  - Hunjan,T
AU  - Phylactou,M
AU  - Patel,B
AU  - Muzi,B
AU  - Ettehad,D
AU  - Bassett,P
AU  - Howard,J
AU  - Rabiner,E
AU  - Bech,P
AU  - Abbara,A
AU  - Goldmeier,D
AU  - Comninos,A
AU  - Dhillo,W
DO  - 10.1001/jamanetworkopen.2022.54313
EP  - 16
PY  - 2023///
SN  - 2574-3805
SP  - 1
TI  - Effects of kisspeptin on sexual brain processing and penile tumescence in men with hypoactive sexual desire disorder: a randomized clinical trial
T2  - Jama Network Open
UR  - http://dx.doi.org/10.1001/jamanetworkopen.2022.54313
UR  - https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2800937
UR  - http://hdl.handle.net/10044/1/102629
VL  - 6
ER  -

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