Imperial College London
Alternate

ProfessorWaljitDhillo

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Professor of Endocrinology & Metabolism
 
 
 
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Contact

 

+44 (0)20 7594 3487w.dhillo Website

 
 
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Assistant

 

Ms Suzanne Wheeler +44 (0)20 7594 3487

 
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Location

 

6N6ECommonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Abbara:2023:clinem/dgad026,
author = {Abbara, A and Phylactou, M and Eng, PC and Clarke, S and Pham, T and Ho, TM and Ng, KY and Mills, E and Purugganan, K and Hunjan, T and Salim, R and Comninos, A and Vuong, L and Dhillo, WS},
doi = {clinem/dgad026},
journal = {Journal of Clinical Endocrinology and Metabolism},
pages = {1666--1675},
title = {Endocrine responses to triptorelin in healthy women, women with polycystic ovary syndrome and hypothalamic amenorrhea},
url = {http://dx.doi.org/10.1210/clinem/dgad026},
volume = {108},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - ContextLimited data exist regarding whether the endocrine response to the gonadotropin-releasing hormone receptor agonist (GnRHa) triptorelin differs in women with polycystic ovary syndrome (PCOS) compared with healthy women or those with hypothalamic amenorrhea (HA).ObjectiveWe compared the gonadotropin response to triptorelin in healthy women, women with PCOS, or those with HA without ovarian stimulation, and in women with or without polycystic ovaries undergoing oocyte donation cycles after ovarian stimulation.MethodsThe change in serum gonadotropin levels was determined in (1) a prospective single-blinded placebo-controlled study to determine the endocrine profile of triptorelin (0.2 mg) or saline-placebo in healthy women, women with PCOS, and those with HA, without ovarian stimulation; and (2) a retrospective analysis from a dose-finding randomized controlled trial of triptorelin (0.2-0.4 mg) in oocyte donation cycles after ovarian stimulation.ResultsIn Study 1, triptorelin induced an increase in serum luteinizing hormone (LH) of similar amplitude in all women (mean peak LH: healthy, 52.3; PCOS, 46.2; HA, 41.3IU/L). The AUC of change in serum follicle-stimulating hormone (FSH) was attenuated in women with PCOS compared with healthy women and women with HA (median AUC of change in serum FSH: PCOS, 127.2; healthy, 253.8; HA, 326.7IU.h/L; P = 0.0005). In Study 2, FSH levels 4hours after triptorelin were reduced in women with at least one polycystic morphology ovary (n = 60) vs normal morphology ovaries (n = 91) (34.0 vs 42.3IU/L; P = 0.0003). Serum anti-Müllerian hormone (AMH) was negatively associated with the increase in FSH after triptorelin, both with and without ovarian stimulation.ConclusionFSH response to triptorelin was attenuated in women with polycystic ovaries, both with and without ovarian stimulation, and was negatively related to AMH levels.
AU  - Abbara,A
AU  - Phylactou,M
AU  - Eng,PC
AU  - Clarke,S
AU  - Pham,T
AU  - Ho,TM
AU  - Ng,KY
AU  - Mills,E
AU  - Purugganan,K
AU  - Hunjan,T
AU  - Salim,R
AU  - Comninos,A
AU  - Vuong,L
AU  - Dhillo,WS
DO  - clinem/dgad026
EP  - 1675
PY  - 2023///
SN  - 0021-972X
SP  - 1666
TI  - Endocrine responses to triptorelin in healthy women, women with polycystic ovary syndrome and hypothalamic amenorrhea
T2  - Journal of Clinical Endocrinology and Metabolism
UR  - http://dx.doi.org/10.1210/clinem/dgad026
UR  - https://academic.oup.com/jcem/advance-article/doi/10.1210/clinem/dgad026/6991760?login=false
UR  - http://hdl.handle.net/10044/1/102765
VL  - 108
ER  -
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