Imperial College London
Alternate

ProfessorWaljitDhillo

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Professor of Endocrinology & Metabolism
 
 
 
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Contact

 

+44 (0)20 7594 3487w.dhillo Website

 
 
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Assistant

 

Ms Suzanne Wheeler +44 (0)20 7594 3487

 
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Location

 

6N6ECommonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Koysombat:2024:10.1016/j.beem.2023.101774,
author = {Koysombat, K and McGown, P and Nyunt, S and Abbara, A and Dhillo, WS},
doi = {10.1016/j.beem.2023.101774},
journal = {Best Practice and Research: Clinical Endocrinology and Metabolism},
pages = {1--17},
title = {New advances in menopause symptom management},
url = {http://dx.doi.org/10.1016/j.beem.2023.101774},
volume = {38},
year = {2024}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Vasomotor symptoms (VMS) are characteristic of menopause experienced by over 75% of postmenopausal women with significant health and socioeconomic implications. Although the average duration of symptoms is seven years, 10% of women experience symptoms for more than a decade. Although menopausal hormone therapy (MHT) remains an efficacious and cost-effective treatment, its use may not be suitable in all women, such as those at an increased risk of breast cancer or gynaecological malignancy. The neurokinin B (NKB) signaling pathway, together with its intricate connection to the median preoptic nucleus (MnPO), has been postulated to provide integrated reproductive and thermoregulatory responses, with a central role in mediating postmenopausal VMS. This review describes the physiological hypothalamo-pituitary-ovary (HPO) axis, and subsequently the neuroendocrine changes that occur with menopause using evidence derived from animal and human studies. Finally, data from the latest clinical trials using novel therapeutic agents that antagonise NKB signaling are reviewed.
AU  - Koysombat,K
AU  - McGown,P
AU  - Nyunt,S
AU  - Abbara,A
AU  - Dhillo,WS
DO  - 10.1016/j.beem.2023.101774
EP  - 17
PY  - 2024///
SN  - 1521-690X
SP  - 1
TI  - New advances in menopause symptom management
T2  - Best Practice and Research: Clinical Endocrinology and Metabolism
UR  - http://dx.doi.org/10.1016/j.beem.2023.101774
UR  - https://www.ncbi.nlm.nih.gov/pubmed/37076317
UR  - https://www.sciencedirect.com/science/article/pii/S1521690X23000453?via%3Dihub
UR  - http://hdl.handle.net/10044/1/104080
VL  - 38
ER  -
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