Imperial College London
Alternate

ProfessorWaljitDhillo

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Professor of Endocrinology & Metabolism
 
 
 
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Contact

 

+44 (0)20 7594 3487w.dhillo Website

 
 
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Assistant

 

Ms Suzanne Wheeler +44 (0)20 7594 3487

 
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Location

 

6N6ECommonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Ramos-Pittol:2023:10.1038/s41467-023-38618-y,
author = {Ramos-Pittol, J and Fernandes-Freitas, I and Milona, A and Manchishi, SM and Rainbow, K and Lam, BYH and Tadross, JA and Beucher, A and Colledge, WH and Cebola, I and Murphy, KG and Miguel-Aiaga, I and Yeo, GSH and Owen, B and Dhillo, W},
doi = {10.1038/s41467-023-38618-y},
journal = {Nature Communications},
pages = {1--10},
title = {Dax1 modulates ERα-dependent hypothalamic estrogen sensing in female mice},
url = {http://dx.doi.org/10.1038/s41467-023-38618-y},
volume = {14},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Coupling the release of pituitary hormones to the developmental stage of the oocyte is essential for female fertility. It requires estrogen to restrain kisspeptin (KISS1)-neuron pulsatility in the arcuate hypothalamic nucleus, while also exerting a surge-like effect on KISS1-neuron activity in the AVPV hypothalamic nucleus. However, a mechanistic basis for this region-specific effect has remained elusive. Our genomic analysis in female mice demonstrate that some processes, such as restraint of KISS1-neuron activity in the arcuate nucleus, may be explained by region-specific estrogen receptor alpha (ERα) DNA binding at gene regulatory regions. Furthermore, we find that the Kiss1-locus is uniquely regulated in these hypothalamic nuclei, and that the nuclear receptor co-repressor NR0B1 (DAX1) restrains its transcription specifically in the arcuate nucleus. These studies provide mechanistic insight into how ER may control the KISS1-neuron, and Kiss1 gene expression, to couple gonadotropin release to the developmental stage of the oocyte.
AU  - Ramos-Pittol,J
AU  - Fernandes-Freitas,I
AU  - Milona,A
AU  - Manchishi,SM
AU  - Rainbow,K
AU  - Lam,BYH
AU  - Tadross,JA
AU  - Beucher,A
AU  - Colledge,WH
AU  - Cebola,I
AU  - Murphy,KG
AU  - Miguel-Aiaga,I
AU  - Yeo,GSH
AU  - Owen,B
AU  - Dhillo,W
DO  - 10.1038/s41467-023-38618-y
EP  - 10
PY  - 2023///
SN  - 2041-1723
SP  - 1
TI  - Dax1 modulates ERα-dependent hypothalamic estrogen sensing in female mice
T2  - Nature Communications
UR  - http://dx.doi.org/10.1038/s41467-023-38618-y
UR  - https://www.nature.com/articles/s41467-023-38618-y
UR  - http://hdl.handle.net/10044/1/104504
VL  - 14
ER  -
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