Imperial College London
Alternate

ProfessorWaljitDhillo

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Professor of Endocrinology & Metabolism
 
 
 
//

Contact

 

+44 (0)20 7594 3487w.dhillo Website

 
 
//

Assistant

 

Ms Suzanne Wheeler +44 (0)20 7594 3487

 
//

Location

 

6N6ECommonwealth BuildingHammersmith Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Mills:2023:10.3389/fendo.2023.1163771,
author = {Mills, EG and Abbara, A and Dhillo, WS and Comninos, AN},
doi = {10.3389/fendo.2023.1163771},
journal = {Frontiers in Endocrinology},
title = {Effects of distinct Polycystic Ovary Syndrome phenotypes on bone health},
url = {http://dx.doi.org/10.3389/fendo.2023.1163771},
volume = {14},
year = {2023}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Polycystic Ovary Syndrome (PCOS) is a highly prevalent and heterogenous endocrinopathy affecting 5-18% of women. Although its cardinal features include androgen excess, ovulatory dysfunction, and/or polycystic ovarian morphology, women often display related metabolic manifestations, including hyperinsulinaemia, insulin resistance, and obesity. Emerging data reveal that the hormonal alterations associated with PCOS also impact bone metabolism. However, inconsistent evidence exists as to whether PCOS is a bone-protective or bone-hindering disorder with an accumulating body of clinical data indicating that hyperandrogenism, hyperinsulinaemia, insulin resistance, and obesity may have a relative protective influence on bone, whereas chronic low-grade inflammation and vitamin D deficiency may adversely affect bone health. Herein, we provide a comprehensive assessment of the endocrine and metabolic manifestations associated with PCOS and their relative effects on bone metabolism. We focus principally on clinical studies in women investigating their contribution to the alterations in bone turnover markers, bone mineral density, and ultimately fracture risk in PCOS. A thorough understanding in this regard will indicate whether women with PCOS require enhanced surveillance of bone health in routine clinical practice.
AU  - Mills,EG
AU  - Abbara,A
AU  - Dhillo,WS
AU  - Comninos,AN
DO  - 10.3389/fendo.2023.1163771
PY  - 2023///
SN  - 1664-2392
TI  - Effects of distinct Polycystic Ovary Syndrome phenotypes on bone health
T2  - Frontiers in Endocrinology
UR  - http://dx.doi.org/10.3389/fendo.2023.1163771
UR  - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000994826300001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=a2bf6146997ec60c407a63945d4e92bb
UR  - https://www.frontiersin.org/articles/10.3389/fendo.2023.1163771/full
UR  - http://hdl.handle.net/10044/1/107028
VL  - 14
ER  -
Download