Publications
494 results found
Jayaseelan DD, Zapata-Solvas E, Brown P, et al., 2012, <i>In situ</i> Formation of Oxidation Resistant Refractory Coatings on SiC-Reinforced ZrB<sub>2</sub> Ultra High Temperature Ceramics, JOURNAL OF THE AMERICAN CERAMIC SOCIETY, Vol: 95, Pages: 1247-1254, ISSN: 0002-7820
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- Citations: 63
Lee W, 2012, What is it that makes alternative medicine 'alternative'?, Focus on Alternative and Complementary Therapies, Vol: 17, Pages: 2-3, ISSN: 1465-3753
Cui B, Sa R, Jayaseelan DD, et al., 2012, Microstructural evolution during high-temperature oxidation of spark plasma sintered Ti<sub>2</sub>AlN ceramics, ACTA MATERIALIA, Vol: 60, Pages: 1079-1092, ISSN: 1359-6454
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- Citations: 51
Lee WE, Kwok CHT, Hunter ECM, et al., 2012, Prevalence and childhood antecedents of depersonalization syndrome in a UK birth cohort., Soc Psychiatry Psychiatr Epidemiol, Vol: 47, Pages: 253-261
PURPOSE: Depersonalization syndrome is characterised by a sense of unreality about the self [depersonalization (DP)] and/or the outside world [derealization (DR)]. Prevalence estimates vary widely. Little is known about childhood antecedents of the disorder although emotional abuse is thought to play a role. METHODS: Longitudinal data from 3,275 participants of a UK population-based birth cohort (the MRC National Survey of Health and Development) were used to: (1) assess the prevalence of DP syndrome at age 36, measured by the Present State Examination (PSE); and (2) examine the effects of a range of socio-demographic, childhood adversity and emotional responses as potential risk factors for DP. RESULTS: Thirty three survey members were classified with DP, yielding a prevalence of 0.95% [95% confidence intervals (CI) 0.56-1.34]. There were no associations with socio-economic status, parental death or divorce; self-reported accidents, childhood depression, tendency to daydream or reactions to criticism. However, teacher-estimated childhood anxiety was a strong independent predictor of adult depersonalization, and there were strong cross-sectional relationships between DP and anxiety and depression caseness. CONCLUSIONS: To our knowledge this is the first study assessing nationwide prevalence of the DP syndrome and uses longitudinal data to explore childhood risk factors for adult DP. The prevalence of adult DP was slightly lower than reported by other surveys. The study found that childhood anxiety was the only significant predictor of the adult DP syndrome, supporting the view that depersonalisation disorder forms part of the spectrum of responses to anxiety.
Desimone D, Jayaseelan DD, Lee WE, et al., 2012, Development of ZrO<sub>2</sub> interfaces for all-oxide composites, COMPOSITES SCIENCE AND TECHNOLOGY, Vol: 72, Pages: 197-203, ISSN: 0266-3538
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- Citations: 8
Lee W, 2012, Aromatherapy for depression and anxiety, Focus on Alternative and Complementary Therapies, Vol: 17, Pages: 235-236, ISSN: 1465-3753
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- Citations: 1
Paul A, Jayaseelan DD, Venugopal S, et al., 2012, UHTC composites for hypersonic applications, AMERICAN CERAMIC SOCIETY BULLETIN, Vol: 91, Pages: 22-28, ISSN: 0002-7812
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- Citations: 196
Goldacre B, Lee W, 2012, Abortion and mental health: guidelines for proper scientific conduct ignored, BRITISH JOURNAL OF PSYCHIATRY, Vol: 200, Pages: 77-77, ISSN: 0007-1250
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- Citations: 5
Lee W, Bindman J, Ford T, et al., 2012, Well controls in case-control studies, PSYCHOLOGICAL MEDICINE, Vol: 42, Pages: 216-217, ISSN: 0033-2917
Jackson HF, Lee WE, 2012, Properties and Characteristics of ZrC, COMPREHENSIVE NUCLEAR MATERIALS, VOL 2: MATERIAL PROPERTIES/OXIDE FUELS FOR LIGHT WATER REACTORS AND FAST NEUTRON REACTORS, Pages: 339-372
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- Citations: 60
Ginn S, Price A, Rayner L, et al., 2011, Senior doctors' opinions of rational suicide., J Med Ethics, Vol: 37, Pages: 723-726
CONTEXT: The attitudes of medical professionals towards physician assisted dying have been widely discussed. Less explored is the level of agreement among physicians on the possibility of 'rational suicide'-a considered suicide act made by a sound mind and a precondition of assisted dying legislation. OBJECTIVE: To assess attitudes towards rational suicide in a representative sample of senior doctors in England and Wales. METHODS: A postal survey was conducted of 1000 consultants and general practitioners randomly selected from a commercially available database. The main outcome of interest was level of agreement with a statement about rational suicide. RESULTS: The corrected participation rate was 50%; 363 questionnaires were analysed. Overall 72% of doctors agreed with the possibility of rational suicide, 17% disagreed, and 11% were neutral. Doctors who identified themselves as being more religious were more likely to disagree. Some doctors who disagreed with legalisation of physician assisted suicide nevertheless agreed with the concept of rational suicide. CONCLUSIONS: Most senior doctors in England and Wales feel that rational suicide is possible. There was no association with specialty. Strong religious belief was associated with disagreement, although levels of agreement were still high in people reporting the strongest religious belief. Most doctors who were opposed to physician assisted suicide believed that rational suicide was possible, suggesting that some medical opposition is best explained by other factors such as concerns of assessment and protection of vulnerable patients.
Cui B, Jayaseelan DD, Lee WE, 2011, Reply to comment on "Microstructural evolution during high-temperature oxidation of Ti<sub>2</sub>AlC ceramics", SCRIPTA MATERIALIA, Vol: 65, Pages: 933-934, ISSN: 1359-6462
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- Citations: 4
Hayes RD, Chang C-K, Fernandes A, et al., 2011, Associations between substance use disorder sub-groups, life expectancy and all-cause mortality in a large British specialist mental healthcare service., Drug Alcohol Depend, Vol: 118, Pages: 56-61
BACKGROUND: People with substance use disorders (SUDs) have increased risk of mortality but risk in sub-groups is poorly understood. METHODS: SUD cases, aged 15 years or older, were identified in the South London and Maudsley Case Register which contains over 150,000 specialist mental healthcare and addictions service users linked to regular national mortality tracing. Standardized mortality ratios (SMRs) for the period 2007-2009 were calculated based on expected numbers of deaths for England and Wales in 2008 then stratified by gender, age, ethnicity, and type of substance use disorder. Life expectancies at birth were estimated. RESULTS: We detected 10,927 cases with a primary substance use disorder diagnosis prior to 2010, who were active to South London and Maudsley NHS Foundation Trust services between 2007 and 2009. Alcohol and opioid use disorders were the most common disorders (45.4% and 44.2% of the SUD cohort respectively) and were associated with increased mortality (SMRs 4.04 and 4.85 respectively). Subgroups at particularly high risk were women with opioid use disorder (SMR 7.32) and those under the age of 45 years with alcohol use disorder (SMR 9.25). SMRs associated with alcohol and opioid use disorders diminished with age. Life expectancies of individuals with alcohol and opioid use disorders were reduced by 9-17 years compared to national norms. CONCLUSIONS: Those under 45 years with alcohol use disorder and women with opioid use disorder are at particularly high risk of mortality. More targeted health care is required to address the specific needs of these vulnerable subgroups.
Jackson HF, Jayaseelan DD, Manara D, et al., 2011, Laser Melting of Zirconium Carbide: Determination of Phase Transitions in Refractory Ceramic Systems, JOURNAL OF THE AMERICAN CERAMIC SOCIETY, Vol: 94, Pages: 3561-3569, ISSN: 0002-7820
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- Citations: 41
Gilbert M, Davoisne C, Stennett MC, et al., 2011, Krypton and helium irradiation damage in yttria-stabilised zirconia, Materials Research Society Symposium Proceedings, Vol: 1298, Pages: 197-202, ISSN: 0272-9172
A candidate matrix material for inert matrix fuel (IMF), yttria-stabilised zirconia (YSZ) has been doped with Nd3+ as a surrogate for Pu 3+. To simulate and assess the effects of fission gas accommodation and alpha decay on the microstructure, samples of (Y0.1425,Nd 0.05,Zr0.8075)O1.904 have been irradiated with 2 MeV 36Kr+ ions, at fluences of 1×1014 and 5×1015 cm-2, and 200 keV 4He + ions at fluences of 1×1014, 5×10 15 and 1×1017 cm-2. Analysis by transmission electron microscopy (TEM) of thin sections prepared by focussed ion beam (FIB) milling revealed damage was only observed at the highest 36Kr+ and 4He+ fluences. Monte Carlo simulations using the TRIM code showed that it is only at these fluences that the level of atomic displacements was sufficient to result in observable defect cluster formation within the material. © 2011 Materials Research Society.
Ojovan MI, Lee WE, 2011, Glassy and Glass Composite Nuclear Wasteforms, Advances in Materials Science for Environmental and Nuclear Technology II, Pages: 203-216, ISBN: 9781118060001
The current status of vitrification techniques for immobilisation of nuclear wastes in glasses and glass composite materials (GCM) are reviewed. One-stage and two-stage processes are described along with the compositions and properties of the resulting glassy wasteforms. Techniques for assessing wasteform durability are discussed along with the mechanisms of corrosion on contact with groundwater.
Gilbert M, Davoisne C, Stennett M, et al., 2011, Krypton and helium irradiation damage in neodymium-zirconolite, JOURNAL OF NUCLEAR MATERIALS, Vol: 416, Pages: 221-224, ISSN: 0022-3115
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- Citations: 12
Davoisne C, Stennett MC, Hyatt NC, et al., 2011, Krypton irradiation damage in Nd-doped zirconolite and perovskite, JOURNAL OF NUCLEAR MATERIALS, Vol: 415, Pages: 67-73, ISSN: 0022-3115
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- Citations: 12
Rose PB, Woodward DI, Ojovan MI, et al., 2011, Crystallisation of a simulated borosilicate high-level waste glass produced on a full-scale vitrification line, JOURNAL OF NON-CRYSTALLINE SOLIDS, Vol: 357, Pages: 2989-3001, ISSN: 0022-3093
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- Citations: 41
Hotopf M, Price A, Lee W, 2011, Authors' reply, British Journal of Psychiatry, Vol: 198, ISSN: 0007-1250
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- Citations: 1
Cui B, Jayaseelan DD, Lee WE, 2011, Microstructural evolution during high-temperature oxidation of Ti<sub>2</sub>AlC ceramics, ACTA MATERIALIA, Vol: 59, Pages: 4116-4125, ISSN: 1359-6454
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- Citations: 82
Ojovan MI, Lee WE, 2011, Glassy Wasteforms for Nuclear Waste Immobilization, METALLURGICAL AND MATERIALS TRANSACTIONS A-PHYSICAL METALLURGY AND MATERIALS SCIENCE, Vol: 42A, Pages: 837-851, ISSN: 1073-5623
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- Citations: 201
Rayner L, Lee W, Price A, et al., 2011, The clinical epidemiology of depression in palliative care and the predictive value of somatic symptoms: cross-sectional survey with four-week follow-up., Palliat Med, Vol: 25, Pages: 229-241
This cross-sectional survey aimed to determine the prevalence and remission of depression in patients receiving palliative care and to ascertain the predictive value of somatic symptoms in making the diagnosis. Three hundred consecutive patients were interviewed within one week of their initial assessment by a specialist nurse at a palliative care service with in-patient and homecare facilities in south London, UK. Depression was assessed using the PRIME-MD PHQ-9. Presence of somatic symptoms (fatigue, sleep disturbance, poor appetite) was determined using the EORTC-QLQ-C30 quality of life questionnaire. Fifty-eight (19.3% [15.3 to 23.3]) patients met criteria for Major Depressive Disorder; 109 (36.3% [32.3 to 40.3]) met criteria for 'Any depressive syndrome'. Patients with Major Depressive Disorder were more likely to be male, and to have non-malignant disease, pain, poor performance status and desire for an early death. Of those patients with Major Depressive Disorder at baseline, 69% (27/39) had remitted four weeks later. Of those not depressed at baseline, 11% (19/174) met criteria for depression at follow-up. The positive predictive values of sleep disturbance, poor appetite and fatigue were low (<24%), whereas the negative predictive values of these symptoms were high (>89%). The high prevalence of depression in palliative care attests to the need for psychological assessment and support. Depression in patients receiving palliative care is unstable, suggesting that symptoms should be carefully monitored.
Eakins E, Jayaseelan DD, Lee WE, 2011, Toward Oxidation-Resistant ZrB<sub>2</sub>-SiC Ultra High Temperature Ceramics, METALLURGICAL AND MATERIALS TRANSACTIONS A-PHYSICAL METALLURGY AND MATERIALS SCIENCE, Vol: 42A, Pages: 878-887, ISSN: 1073-5623
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- Citations: 109
Jayaseelan DD, de Sa RG, Brown P, et al., 2011, Reactive infiltration processing (RIP) of ultra high temperature ceramics (UHTC) into porous C/C composite tubes, JOURNAL OF THE EUROPEAN CERAMIC SOCIETY, Vol: 31, Pages: 361-368, ISSN: 0955-2219
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- Citations: 89
Hotopf M, Lee W, Price A, 2011, Assisted suicide: why psychiatrists should engage in the debate., Br J Psychiatry, Vol: 198, Pages: 83-84
There is an increasing appetite for a change in the law to allow assisted suicide. This editorial suggests that psychiatrists should engage in the debate because the issues at stake will affect us, and we are likely to have a significant part to play were the law to be changed. We suggest that there are three main areas where psychiatrists' expertise may be informative: (a) the extent to which safeguards to limit the availability of assisted dying to target groups can be applied safely and fairly, including to individuals with psychiatric disorders; (b) the complexities inherent in assessing mental capacity; and (c) the degree to which individuals adapt or change their desires, particularly in relation to suicidal behaviours.
Jayaseelan DD, Wang Y, Hilmas GE, et al., 2011, TEM investigation of hot pressed-10 vol.% SiC-ZrB<sub>2</sub> composite, ADVANCES IN APPLIED CERAMICS, Vol: 110, Pages: 1-7, ISSN: 1743-6753
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- Citations: 48
Chang C-K, Hayes RD, Perera G, et al., 2011, Life expectancy at birth for people with serious mental illness and other major disorders from a secondary mental health care case register in London., PLoS One, Vol: 6
OBJECTIVE: Despite improving healthcare, the gap in mortality between people with serious mental illness (SMI) and general population persists, especially for younger age groups. The electronic database from a large and comprehensive secondary mental healthcare provider in London was utilized to assess the impact of SMI diagnoses on life expectancy at birth. METHOD: People who were diagnosed with SMI (schizophrenia, schizoaffective disorder, bipolar disorder), substance use disorder, and depressive episode/disorder before the end of 2009 and under active review by the South London and Maudsley NHS Foundation Trust (SLAM) in southeast London during 2007-09 comprised the sample, retrieved by the SLAM Case Register Interactive Search (CRIS) system. We estimated life expectancy at birth for people with SMI and each diagnosis, from national mortality returns between 2007-09, using a life table method. RESULTS: A total of 31,719 eligible people, aged 15 years or older, with SMI were analyzed. Among them, 1,370 died during 2007-09. Compared to national figures, all disorders were associated with substantially lower life expectancy: 8.0 to 14.6 life years lost for men and 9.8 to 17.5 life years lost for women. Highest reductions were found for men with schizophrenia (14.6 years lost) and women with schizoaffective disorders (17.5 years lost). CONCLUSION: The impact of serious mental illness on life expectancy is marked and generally higher than similarly calculated impacts of well-recognised adverse exposures such as smoking, diabetes and obesity. Strategies to identify and prevent causes of premature death are urgently required.
Ojovan MI, Lee WE, 2011, GLASSY AND GLASS COMPOSITE NUCLEAR WASTEFORMS, ADVANCES IN MATERIALS SCIENCE FOR ENVIRONMENTAL AND NUCLEAR TECHNOLOGY II, Vol: 227, Pages: 203-216, ISSN: 1042-1122
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- Citations: 7
Coupland VH, Lee W, Madden P, et al., 2010, Is it possible to determine use of hospice palliative care services by matching hospice and cancer registry data?, Palliat Med, Vol: 24, Pages: 807-811
Population-based studies investigating access to palliative care often use death in a hospice as a proxy for service use. We linked data from a large South London hospice to Thames Cancer Registry (TCR) data to determine whether patients who received hospice services differed from those who did not. We matched hospice data for 2474 cancer patients dying between 2000 and 2006, while resident within a restricted catchment area, to TCR data for residents in this area. During matching 14.2% (n = 352) of hospice patients were excluded due to differing key dates or addresses. In addition, 5.6% (n= 175) of residents initially defined as not receiving hospice services were recorded as dying in a hospice in the TCR dataset. The problems of overlapping catchment areas and of defining patients receiving services meant we could not adequately determine use of hospice services. This method might be applied more successfully to non-urban hospices, primary care trusts or larger regions.
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