Publications
45 results found
Wiles S, Hanage WP, Frankel G, et al., 2006, Modelling infectious disease - time to think outside the box?, NATURE REVIEWS MICROBIOLOGY, Vol: 4, Pages: 307-312, ISSN: 1740-1526
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- Citations: 43
Hanage WP, Fraser C, Spratt BG, 2006, The impact of homologous recombination on the generation of diversity in bacteria, JOURNAL OF THEORETICAL BIOLOGY, Vol: 239, Pages: 210-219, ISSN: 0022-5193
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- Citations: 85
Hanage WP, Kaijalainen T, Saukkoriipi A, et al., 2006, A successful, diverse disease-associated lineage of nontypeable pneumococci that has lost the capsular biosynthesis locus, JOURNAL OF CLINICAL MICROBIOLOGY, Vol: 44, Pages: 743-749, ISSN: 0095-1137
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- Citations: 46
Fisher MC, Hanage WP, de Hoog S, et al., 2005, Low effective dispersal of asexual genotypes in heterogeneous landscapes by the endemic pathogen <i>Penicillium marneffei</i>, PLOS PATHOGENS, Vol: 1, Pages: 159-165, ISSN: 1553-7366
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- Citations: 48
Hanage WP, Kaijalainen T, Herva E, et al., 2005, Using multilocus sequence data to define the pneumococcus, JOURNAL OF BACTERIOLOGY, Vol: 187, Pages: 6223-6230, ISSN: 0021-9193
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- Citations: 80
Hanage WP, Fraser C, Spratt BG, 2005, Fuzzy species among recombinogenic bacteria, BMC Biology, Vol: 3, ISSN: 1741-7007
Background: It is a matter of ongoing debate whether a universal species concept is possible forbacteria. Indeed, it is not clear whether closely related isolates of bacteria typically form discretegenotypic clusters that can be assigned as species. The most challenging test of whether species canbe clearly delineated is provided by analysis of large populations of closely-related, highlyrecombinogenic, bacteria that colonise the same body site. We have used concatenated sequencesof seven house-keeping loci from 770 strains of 11 named Neisseria species, and phylogenetic trees,to investigate whether genotypic clusters can be resolved among these recombinogenic bacteriaand, if so, the extent to which they correspond to named species.Results: Alleles at individual loci were widely distributed among the named species but thisdistorting effect of recombination was largely buffered by using concatenated sequences, whichresolved clusters corresponding to the three species most numerous in the sample, N. meningitidis,N. lactamica and N. gonorrhoeae. A few isolates arose from the branch that separated N. meningitidisfrom N. lactamica leading us to describe these species as 'fuzzy'.Conclusion: A multilocus approach using large samples of closely related isolates delineatesspecies even in the highly recombinogenic human Neisseria where individual loci are inadequate forthe task. This approach should be applied by taxonomists to large samples of other groups ofclosely-related bacteria, and especially to those where species delineation has historically beendifficult, to determine whether genotypic clusters can be delineated, and to guide the definition ofspecies.
Fraser C, Hanage WP, Spratt BG, 2005, Neutral microepidemic evolution of bacterial pathogens, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 102, Pages: 1968-1973, ISSN: 0027-8424
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- Citations: 102
Hanage WP, Kaijalainen TH, Syrjänen RK, et al., 2005, Invasiveness of serotypes and clones of <i>Streptococcus pneumoniae</i> among children in Finland, INFECTION AND IMMUNITY, Vol: 73, Pages: 431-435, ISSN: 0019-9567
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- Citations: 124
Spratt BG, Hanage WP, Li B, et al., 2004, Displaying the relatedness among isolates of bacterial species - the eBURST approach, FEMS MICROBIOLOGY LETTERS, Vol: 241, Pages: 129-134, ISSN: 0378-1097
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- Citations: 162
Feil EJ, Li BC, Aanensen DM, et al., 2004, eBURST: Inferring patterns of evolutionary descent among clusters of related bacterial genotypes from multilocus sequence typing data, JOURNAL OF BACTERIOLOGY, Vol: 186, Pages: 1518-1530, ISSN: 0021-9193
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- Citations: 1477
Hanage WP, Auranen K, Syrjänen R, et al., 2004, Ability of pneumococcal serotypes and clones to cause acute otitis media:: Implications for the prevention of otitis media by conjugate vaccines, INFECTION AND IMMUNITY, Vol: 72, Pages: 76-81, ISSN: 0019-9567
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- Citations: 62
Hanage WP, Feil EJ, Brueggemann AB, et al., 2004, Multilocus sequence typing: strain characterization, population biology, and patterns of evolutionary descent., Molecular Microbiology: Diagnostic Principles and Practice., Editors: new
Spratt BG, Hanage WP, Brueggemann AB, 2004, Evolutionary and population biology of Streptococcus pneumoniae, The Pneumococcus, Editors: Tuomanen, Mitchell, Morrison, Spratt BG, Publisher: ASM Press, Pages: 119-135, ISBN: 9781555812973
Hanage WP, Cohen J, 2002, Stimulation of cytokine release and adhesion molecule expression by products of viridans streptococci, JOURNAL OF INFECTIOUS DISEASES, Vol: 185, Pages: 357-367, ISSN: 0022-1899
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- Citations: 9
Spratt BG, Hanage WP, Feil EJ, 2001, The relative contributions of recombination and point mutation to the diversification of bacterial clones, CURRENT OPINION IN MICROBIOLOGY, Vol: 4, Pages: 602-606, ISSN: 1369-5274
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- Citations: 113
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