Imperial College London
Portrait Picture

DrWafaKhamri

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Senior Teaching Fellow
 
 
 
//

Contact

 

w.khamri

 
 
//

Location

 

Queen Elizabeth the Queen Mother Wing (QEQM)St Mary's Campus

//

Summary

 

Publications

Citation

BibTex format

@inbook{Thursz:2009:10.1016/B978-0-12-374546-0.00035-3,
author = {Thursz, MR and Khamri, W},
booktitle = {Microbial Glycobiology: Structures, Relevance and Applications},
doi = {10.1016/B978-0-12-374546-0.00035-3},
pages = {697--713},
title = {Host surfactant proteins in microbial recognition},
url = {http://dx.doi.org/10.1016/B978-0-12-374546-0.00035-3},
year = {2009}
}
Download

RIS format (EndNote, RefMan)

TY  - CHAP
AB  - The cellular responses of host defenses against microbial invasion require pathogen-associated molecular pattern (PAMPs) recognition molecules. Surfactant proteins (SP) SP-A and SP-D, members of the collectin family, recognize PAMPs and act as important mediators of the immune system. Both SP-A and SP-D interact with various microorganism- and pathogen-derived components by binding to complex carbohydrate structures of bacterial, viral, and fungal cells. The binding occurs via the surfactant carbohydrate recognition domain and leads to the agglutination and enhancement of pathogen clearance by specialized immune cells. In addition to their interaction with bacterial cells, SP-A and SP-D have a direct effect on immune cell function. This chapter discusses the structure, biosynthesis, ligands, and functions of SP-A and SP-D. Furthermore, the possible clinical applications for both SP-A and SP-D are highlighted.
AU  - Thursz,MR
AU  - Khamri,W
DO  - 10.1016/B978-0-12-374546-0.00035-3
EP  - 713
PY  - 2009///
SN  - 9780123745460
SP  - 697
TI  - Host surfactant proteins in microbial recognition
T1  - Microbial Glycobiology: Structures, Relevance and Applications
UR  - http://dx.doi.org/10.1016/B978-0-12-374546-0.00035-3
ER  -
Download