Publications
45 results found
Stanley SA, Murphy KG, Bewick GA, et al., 2004, Regulation of rat pituitary cocaine- and amphetamine-regulated transcript (CART) by CRH and glucocorticoids, American Journal of Physiology Endocrinology and Metabolism, Vol: 287, Pages: E583-E590
Kong WM, 2004, The regulation of gene therapy research in competent adult patients, today and tomorrow: implications of EU Directive 2001/20/EC., Med Law Rev, Vol: 12, Pages: 164-180, ISSN: 0967-0742
le Roux CW, Chapman GA, Kong WM, et al., 2003, Free cortisol index is better than serum total cortisol in determining hypothalamic-pituitary-adrenal status in patients undergoing surgery, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, Vol: 88, Pages: 2045-2048, ISSN: 0021-972X
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- Citations: 102
Kong WM, Stanley S, Gardiner J, et al., 2003, A role for arcuate cocaine and amphetamine-regulated transcript in hyperphagia, thermogenesis, and cold adaptation., The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol: 17, Pages: 1688-1690
We have recently shown that injection of the hypothalamic peptide cocaine and amphetamine regulated transcript (CART) into discrete hypothalamic nuclei stimulates food intake. This stimulation was particularly marked in the arcuate nucleus. Here we show that twice daily intra-arcuate injection of 0.2 nmole CART peptide for 7 days was associated with a 60% higher daytime food intake, an 85% higher thermogenic response to the beta3 agonist BRL 35135, and a 60% increase in brown adipose tissue UCP-1 mRNA. In a separate study, using stereotactically targeted gene transfer, a CART transgene was delivered by using polyethylenimine to the arcuate nucleus of adult rats. Food intake was increased significantly during ad libitum feeding and following periods of food withdrawal and food restriction in CART over-expressing animals. CART over-expressing animals lost 12% more weight than controls following a 24-h fast. Brown adipose tissue uncoupling protein-1 (UCP-1) mRNA levels (collected Day 25) were 80% higher in CART over-expressing animals. Finally, by using quantitative in situ hybridization, we found that chronic cold exposure (20 days at 4oC) increased arcuate nucleus CART mRNA by 124%. Together with the orexigenic and thermogenic effects of CART, this finding suggests a role for arcuate nucleus CART in cold adaptation.
Ward H, Gardiner J, Kong WM, et al., 2003, Distribution of fluorescence following injection of recombinant adeno-associated virus encoding green fluorescent protein into the paraventricular nucleus, Neuroendocrinology, Vol: 77, Pages: 100-104
Kong WM, Stanley S, Gardiner J, et al., 2003, A role for arcuate cocaine and amphetamine-regulated transcript in hyperphagia, thermogenesis, and cold adaptation., FASEB J, Vol: 15, Pages: 1688-1690
Kong WM, Sheikh MH, Lumb PJ, et al., 2002, A 6-month randomized trial of thyroxine treatment in women with mild subclinical hypothyroidism. (vol 112, pg 348, 2002), AMERICAN JOURNAL OF MEDICINE, Vol: 113, Pages: 442-442, ISSN: 0002-9343
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- Citations: 4
le Roux CW, Sivakumaran S, Alaghband-Zadeh J, et al., 2002, Free cortisol index as a surrogate marker for serum free cortisol, ANNALS OF CLINICAL BIOCHEMISTRY, Vol: 39, Pages: 406-408, ISSN: 0004-5632
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- Citations: 76
Kong WM, Sheikh MH, Lumb PJ, et al., 2002, A 6-month Randomized trial of thyroxine treatment in women with mild subclinical hypothyroidism, AMERICAN JOURNAL OF MEDICINE, Vol: 112, Pages: 348-354, ISSN: 0002-9343
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- Citations: 164
Dhillo WS, Kong WM, Le Roux CW, et al., 2002, Cortisol-binding globulin is important in the interpretation of dynamic tests of the hypothalamic-pituitary-adrenal axis, EUROPEAN JOURNAL OF ENDOCRINOLOGY, Vol: 146, Pages: 231-235, ISSN: 0804-4643
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- Citations: 66
le Roux CW, Sivakumarn J, Alaghband-Zadeh J, et al., 2002, Free cortisol index as a surrogate marker for serum free cortisol., Annals of Clinical Biochemistry, Vol: 39, Pages: 406-406
Kong WM, Sheikh M, Lumb P, et al., 2002, A Six Month Randomized Trial of Thyroxine Treatment in Mild Subclinical Hypothyroidism in Women, American Journal of Medicine, Vol: 112, Pages: 348-354
Kim MS, Small CJ, Stanley SA, et al., 2000, The central melanocortin system affects the hypothalamo-pituitary thyroid axis and may mediate the effect of leptin, Journal of Clinical Investigation, Vol: 105, Pages: 1005-1011, ISSN: 0021-9738
Prolonged fasting is associated with a downregulation of the hypothalamo-pituitary thyroid (H-P-T) axis, which is reversed by administration of leptin. The hypothalamic melanocortin system regulates energy balance and mediates a number of central effects of leptin. In this study, we show that hypothalamic melanocortins can stimulate the thyroid axis and that their antagonist, agouti-related peptide (Agrp), can inhibit it. Intracerebroventricular (ICV) administration of Agrp (83-132) decreased plasma thyroid stimulating hormone (TSH) in fed male rats. Intraparaventricular nuclear administration of Agrp (83-132) produced a long-lasting suppression of plasma TSH, and plasma T4. ICV administration of a stable α-MSH analogue increased plasma TSH in 24-hour–fasted rats. In vitro, α-MSH increased thyrotropin releasing hormone (TRH) release from hypothalamic explants. Agrp (83-132) alone caused no change in TRH release but antagonized the effect of α-MSH on TRH release. Leptin increased TRH release from hypothalami harvested from 48-hour–fasted rats. Agrp (83-132) blocked this effect. These data suggest a role for the hypothalamic melanocortin system in the fasting-induced suppression of the H-P-T axis.
Kong WM, Alaghband-Zadeh J, Latham K, et al., 1999, The Midnight to Morning Urinary Cortisol Increment Is an Accurate, Non-invasive Method for Assessment of the Hypothalamo-Pituitary-Adrenal Axis., Journal of Clinical Endocrinology and Metabolism, Vol: 84, Pages: 3093-3098
CLEMONS MJ, KONG WM, 1993, DO WE NEED MORE HOSPICES, BRITISH MEDICAL JOURNAL, Vol: 307, Pages: 205-205, ISSN: 0959-8138
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