Imperial College London
Alternate

Dr Warren Macdonald

Faculty of Engineering, Department of Bioengineering

Senior Teaching Fellow
 
 
 
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Contact

 

+44 (0)20 7594 6372w.macdonald

 
 
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Location

 

B 3.25Bessemer BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@inproceedings{Kazezian:2020,
author = {Kazezian, Z and Yu, X and Ramette, M and Macdonald, W and Bull, A},
title = {Development of a blast injury model for investigating conditions associated with traumatic amputations},
url = {http://hdl.handle.net/10044/1/90805},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - CPAPER
AB  - INTRODUCTION: Most injuries in recent conflicts are due to blast, 70% of which are to the extremities resulting in a large number of lower limb amputations. Functional deficits due to blast induced amputation include difficulty in weight bearing and associated normal gait abnormali-ties. Significant complications following traumatic amputation are pain in the residual limb, and phantom limb pain. Heterotopic Ossification (HO) - ectopic bone formation in the soft tissues - is also highly prevalent (64%) among blast-related military amputations. The existing non-specific treatments include non-steroidal anti-inflammatory drugs (NSAID)s and low-dose radiation therapy which remain unsatisfactory leav-ing surgical bone excision the only possible curative treatment. While the prevention of HO in military amputees is the ultimate choice of treat-ment, it is yet to be identified, as the initial cause of triggering the disease is not understood. For this reason, and because studying amputation complications in humans is difficult, novel in vivo models need to be developed for further understanding of the disease mechanisms. There-fore, we hypothesised that developing a preclinical blast injury model in the hindlimb of rats which better represents the IED detonation in en-closed spaces could answer questions regarding the exact mechanism of HO and phantom limb pain. Current in vivo models exist, but none of these incorporate all blast features, that is, the blast, and the fracture in one insult. This research aims to develop a novel translational blast injury model in rats to better understand the mechanisms of phantom limb pain and HO.METHODS: This study was performed under institutional and departmental license from the Home Office UK. In line with the 3Rs principle, optimisation of the blast pressure was achieved using 34 male cadaveric Sprague-Dawley rats weighing between 285-481g to refine the experi-ments without using live animals to achieve a trans-tibial fracture at
AU  - Kazezian,Z
AU  - Yu,X
AU  - Ramette,M
AU  - Macdonald,W
AU  - Bull,A
PY  - 2020///
TI  - Development of a blast injury model for investigating conditions associated with traumatic amputations
UR  - http://hdl.handle.net/10044/1/90805
ER  -
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