Imperial College London

DrWilliamMan

Faculty of MedicineNational Heart & Lung Institute

Reader in Respiratory Medicine
 
 
 
//

Contact

 

+44 (0)1895 828 851w.man

 
 
//

Location

 

Harefield HospitalHarefield Hospital

//

Summary

 

Publications

Publication Type
Year
to

239 results found

Barker RE, Kon SS, Clarke SF, Wenneberg J, Nolan CM, Patel S, Walsh JA, Polgar O, Maddocks M, Farquhar M, Hopkinson NS, Bell D, Wedzicha JA, Man WD-Cet al., 2021, COPD discharge bundle and pulmonary rehabilitation referral and uptake following hospitalisation for acute exacerbation of COPD, Thorax, ISSN: 0040-6376

Pulmonary rehabilitation (PR) following hospitalisations for acute exacerbation of COPD (AECOPD) is associated with improved exercise capacity and quality of life, and reduced readmissions. However, referral for, and uptake of, post-hospitalisation PR are low. In this prospective cohort study of 291 consecutive hospitalisations for AECOPD, COPD discharge bundles delivered by PR practitioners compared with non-PR practitioners were associated with increased PR referral (60% vs 12%, p<0.001; adjusted OR: 14.46, 95% CI: 5.28 to 39.57) and uptake (40% vs 32%, p=0.001; adjusted OR: 8.60, 95% CI: 2.51 to 29.50). Closer integration between hospital and PR services may increase post-hospitalisation PR referral and uptake.

Journal article

Patel S, Palmer MD, Nolan CM, Barker RE, Walsh JA, Wynne SC, Jones SE, Shannon H, Hopkinson NS, Kon SSC, Gao W, Maddocks M, Man WD-Cet al., 2021, Supervised pulmonary rehabilitation using minimal or specialist exercise equipment in COPD: a propensity-matched analysis, Thorax, Vol: 76, Pages: 264-271, ISSN: 0040-6376

BACKGROUND: Many trials supporting the benefits of pulmonary rehabilitation (PR) have used specialist exercise equipment, such as treadmills and cycle ergometers. However, access to specialist equipment may not be feasible in some settings. There is growing interest in delivering PR programmes with minimal, low-cost equipment, but uncertainty remains regarding their efficacy compared with programmes using specialist equipment. METHODS: Using propensity score matching, 318 consecutive patients with COPD undergoing supervised PR using minimal equipment (PR-min) were compared 1:1 with a control group of 318 patients with COPD who underwent supervised PR using specialist equipment (PR-gym). A non-inferiority analysis was performed for the primary outcome (incremental shuttle walk (ISW)) and secondary outcomes (Chronic Respiratory Disease Questionnaire (CRQ)-domain and total scores). RESULTS: Similar improvements in ISW and CRQ-domains were observed in PR-min and PR-gym groups (mean difference ISW: 3 m (95% CI -16 to 9); CRQ-total: 0.9 (95% CI -2.7 to 4.5)). The 95% CI between group differences for ISW and CRQ-total did not cross the predefined non-inferiority margins. However, completion rates were lower in PR-min compared with PR-gym (64% vs 73%; p=0.014). CONCLUSIONS: In patients with COPD, PR delivered using minimal equipment produces clinically significant benefits in exercise capacity and health-related quality of life that are non-inferior to rehabilitation delivered using specialist equipment. This study provides support for the provision of PR using minimal exercise equipment, particularly in areas where access to specialist exercise equipment is limited.

Journal article

Barker RE, Brighton LJ, Maddocks M, Nolan CM, Patel S, Walsh JA, Polgar O, Wenneberg J, Kon SSC, Wedzicha JA, Man WDC, Farquhar Met al., 2021, Integrating Home-Based Exercise Training with a Hospital at Home Service for Patients Hospitalised with Acute Exacerbations of COPD: Developing the Model Using Accelerated Experience-Based Co-Design., Int J Chron Obstruct Pulmon Dis, Vol: 16, Pages: 1035-1049

Background: Hospital at home (HaH) schemes allow early discharge of patients hospitalised with an acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Traditional outpatient pulmonary rehabilitation (PR) following an AECOPD has an established evidence-base, but there are issues with low referral, uptake and completion. One commonly cited barrier to PR post-hospitalisation relates to poor accessibility. To address this, the aim of this project was to enrol service users (patients with COPD and informal carers) and healthcare professionals to co-design a model of care that integrates home-based exercise training within a HaH scheme for patients discharged from hospital following AECOPD. Methods: This accelerated experience-based co-design project included three audio-recorded stakeholder feedback events, using key "touchpoints" from previous qualitative interviews and a recent systematic review. Audio-recordings were inductively analysed using directed content analysis. An integrated model of care was then developed and finalised through two co-design groups, with the decision-making process facilitated by the tables of changes approach. Results: Seven patients with COPD, two informal carers and nine healthcare professionals (from an existing outpatient PR service and HaH scheme) participated in the stakeholder feedback events. Four key themes were identified: 1) individualisation, 2) progression and transition, 3) continuity between services, and 4) communication between stakeholders. Two patients with COPD, one informal carer and three healthcare professionals participated in the first joint co-design group, with five healthcare professionals attending a second co-design group. These achieved a consensus on the integrated model of care. The agreed model comprised face-to-face supervised, individually tailored home-based exercise training one to three times a week, delivered during HaH scheme visits where possible by a healthcare profession

Journal article

Philip K, Lewis A, Buttery S, Man W, Fancourt D, Polkey M, Hopkinson Net al., 2020, Moving singing for lung health online in response to COVID-19: experience from a randomised controlled trial, BMJ Open Respiratory Research, Vol: 7, ISSN: 2052-4439

IntroductionSinging for Lung Health (SLH) is a popular arts-in-health activity for people with long-term respiratory conditions. Participants report biopsychosocial benefits, however research on impact is limited. The ‘SHIELD trial’, a randomised controlled, single (assessor) blind, trial of 12 weeks SLH vs usual care for people with Chronic Obstructive Pulmonary Disease (COPD) (n=120) was set-up to help to address this. The first group (n=18, 9 singing and 9 controls) started face-to-face (5 sessions) before changing to online delivery (7 sessions) due to COVID-19 related physical distancing measures. As such, the experience of this group is here reported as a pilot study to inform further research in this area. MethodsWe conducted semi-structured interviews and thematic analysis regarding barriers, facilitators and key considerations for transitioning from face-to-face to online delivery. Pilot quantitative outcomes include attendance, pre and post measures of quality of life and disease impact (SF-36, CAT score), breathlessness (MRC breathlessness scale, Dyspnoea-12), depression (PHQ9), anxiety (GAD-7), balance confidence (ABC scale) and physical activity (clinical visit PROactive physical activity in COPD tool, combining subjective rating and actigraphy). ResultsAttendance was 69% overall, (90% of the face-to-face sessions, 53% online sessions). Analysis of semi-structured interviews identified three themes regarding participation in SLH delivered face-to-face and online, these where 1) perceived benefits; 2) digital barriers (online); 3) digital facilitators (online). Findings were summarised into key considerations for optimising transitioning singing groups from face-to-face to online delivery. Pilot quantitative data suggested possible improvements in depression (treatment effect -4.78 PHQ9 points, p< 0.05, MCID 5) and balance confidence (treatment effect +17.21 ABC Scale points, p=0.04, MCID 14.2).Discussion This study identifies key consider

Journal article

Philip K, Adam L, Williams S, Buttery S, Michael P, Man W, Fancourt D, Hopkinson Net al., 2020, Dance for people with chronic respiratory disease: A qualitative study, BMJ Open, Vol: 10, ISSN: 2044-6055

Objectives To explore the experiences and perceived impact on health and well-being related to participation in a dance group for people with chronic respiratory disease (CRD).Design An exploratory qualitative study using thematic analysis of semistructured interviews.Setting A community dance group in a UK health centre.Participants Convenience sample of long-term dance group participants.Intervention Weekly community dance sessions designed for people with breathlessness, lasting 75 min, led by a trained community dance leader.Results Convenience sample of eight participants, six females, aged 57–87 years (mean 75), with a median 2-year attendance at weekly dance sessions. Long-term attendance was driven by strongly held beliefs regarding the health and well-being benefits of participation. Four key themes were identified: dance as (1) a holistically beneficial activity, with physical and psychosocial health benefits including improved or maintained physical fitness and psychological well-being, and reduced need for healthcare; (2) an integral part of their life; (3) an enjoyable activity; and (4) a source of deep social cohesion.Conclusions Dance group participants perceived a broad range of health benefits of relevance to the biopsychosocial impacts of their respiratory disease. The themes identified are useful in the ongoing planning and evaluation of dance as a holistic complex intervention for people with CRD. Further research is required to assess the extent of health impacts identified, and how dance might be most effectively placed as an option in the management of CRD.

Journal article

Patel S, Barker R, Walsh J, Polgar O, Nolan C, Man Wet al., 2020, The five-repetition sit-to-stand test (5STS) in patients with bronchiectasis: validity and reponsiveness, Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936

Conference paper

Philip K, Lewis A, Williams S, Buttery S, Polkey M, Man W, Fancourt DY, Hopkinson Net al., 2020, Dance for people with chronic respiratory disease: A qualitative study, Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936

Conference paper

Barker RE, Jones SE, Banya W, Fleming S, Kon SSC, Clarke SF, Nolan CM, Patel S, Walsh JA, Maddocks M, Farquhar M, Bell D, Wedzicha JA, Man WD-Cet al., 2020, Reply to: one step at a time: a phased approach to behavioral treatment development in pulmonary rehabilitation, American Journal of Respiratory and Critical Care Medicine, Vol: 202, Pages: 775-777, ISSN: 1073-449X

Journal article

Patel S, Man WD-C, Roberts NJ, 2020, Informal carers and peer support in pulmonary rehabilitation: an underutilized resource?, Current Opinion in Supportive and Palliative Care, Vol: 14, Pages: 213-218, ISSN: 1751-4258

Purpose of review The aim of this review is to discuss the recent literature relating to the involvement of informal carers and peer support in pulmonary rehabilitation.Recent findings Informal carers and peer support have been identified by both patients and healthcare workers as a crucial component in the care of those with chronic respiratory disease at home. Pulmonary rehabilitation, a cornerstone in the management of patients with breathlessness, is limited in its clinical effectiveness by poor referral, uptake and completion rates. Engagement of informal carers and support from peers may help maximize the utilization of pulmonary rehabilitation.Summary This review highlights the need for more good-quality randomized controlled trials in identifying suitable interventions that may increase uptake and completion of pulmonary rehabilitation programmes. Qualitative studies have highlighted the potential for informal carers and peer support to play a key role in the design of research programmes, and in the delivery of pulmonary rehabilitation. This needs to be addressed in future research.

Journal article

Brighton LJ, Bristowe K, Bayly J, Ogden M, Farquhar M, Evans CJ, Man WD, Maddocks Met al., 2020, Experiences of pulmonary rehabilitation in people living with COPD and frailty: a qualitative interview study., Annals of the American Thoracic Society, Vol: 17, Pages: 1213-1221, ISSN: 1546-3222

RATIONALE: People living with both chronic obstructive pulmonary disease (COPD) and frailty have high potential to benefit from pulmonary rehabilitation but face challenges completing programmes. However, research to understand ways to optimise participation in this group is lacking. OBJECTIVE: To explore the experiences, needs and preferences of people with COPD and frailty referred for out-patient pulmonary rehabilitation. METHODS: Semi-structured interviews with people with COPD and physical frailty, purposively sampled by age, living status, level of frailty, and completion of pulmonary rehabilitation. Thematic analysis with a critical realist perspective was used, involving relevant stakeholders with clinical, academic and lived experience for interpretive rigour. RESULTS: 19 people with COPD and frailty were interviewed, with a median age of 78 years (range 58-88). Nine did not complete their pulmonary rehabilitation programme. Four themes were identified: striving to adapt to multidimensional loss, tensions of balancing support with independence, pulmonary rehabilitation as a challenge worth facing, and overcoming unpredictable disruptions to participation. Participants described constantly adapting to their changing health and resulting multidimensional losses (e.g. functional abilities, relationships, confidence). This involved traversing between independence and seeking support, set against a mismatch between their needs and what support is available. People with COPD and frailty can be highly motivated to participate in pulmonary rehabilitation, despite the physical and mental demands it entails, and report a range of benefits. Yet in the context of changeable health, they must often overcome multiple unpredictable disruptions to completing rehabilitation programmes. Participant determination and flexibility of services can facilitate ongoing attendance, but for some, these unpredictable disruptions erode their motivation to attend. CONCLUSIONS: People wi

Journal article

Patel S, Maddocks M, Man WD-C, 2020, Exercise training in COPD: FITT for purpose?, Chest, Vol: 158, Pages: 9-10, ISSN: 0012-3692

Journal article

Polgar O, Aljishi M, Barker RE, Patel S, Walsh JA, Kon SSC, Man WDC, Nolan CMet al., 2020, Digital habits of PR service-users: Implications for home-based interventions during the COVID-19 pandemic, CHRONIC RESPIRATORY DISEASE, Vol: 17, ISSN: 1479-9723

Journal article

Wynne SC, Patel S, Barker RE, Jones SE, Walsh JA, Kon SS, Cairn J, Loebinger MR, Wilson R, Man WD-C, Nolan CMet al., 2020, Anxiety and depression in bronchiectasis: Response to pulmonary rehabilitation and minimal clinically important difference of the Hospital Anxiety and Depression Scale., Chronic Respiratory Disease, Vol: 17, Pages: 1-9, ISSN: 1479-9723

The aims of the study were to evaluate the responsiveness of Hospital Anxiety and Depression Scale-Anxiety (HADS-A) subscale and HADS-Depression (HADS-D) subscale to pulmonary rehabilitation (PR) in patients with bronchiectasis compared to a matched group of patients with chronic obstructive pulmonary disease (COPD) and provide estimates of the minimal clinically important difference (MCID) of HADS-A and HADS-D in bronchiectasis. Patients with bronchiectasis and at least mild anxiety or depression (HADS-A ≥ 8 or/and HADS-D ≥ 8), as well as a propensity score-matched control group of patients with COPD, underwent an 8-week outpatient PR programme (two supervised sessions per week). Within- and between-group changes were calculated in response to PR. Anchor- and distribution-based methods were used to estimate the MCID. HADS-A and HADS-D improved in response to PR in both patients with bronchiectasis and those with COPD (median (25th, 75th centile)/mean (95% confidence interval) change: HADS-A change: bronchiectasis -2 (-5, 0), COPD -2 (-4, 0); p = 0.43 and HADS-D change: bronchiectasis -2 (-2 to -1), COPD -2 (-3 to -2); p = 0.16). Using 26 estimates, the MCID for HADS-A and HADS-D was -2 points. HADS-A and HADS-D are responsive to PR in patients with bronchiectasis and symptoms of mood disorder, with an MCID estimate of -2 points.

Journal article

Barker RE, Jones SE, Banya W, Fleming S, Kon SSC, Clarke SF, Nolan CM, Patel S, Walsh JA, Maddocks M, Farquhar M, Bell D, Wedzicha JA, Man WD-Cet al., 2020, The effects of a video intervention on post-hospitalization pulmonary rehabilitation uptake: a randomized controlled trial., American Journal of Respiratory and Critical Care Medicine, Vol: 201, Pages: 1517-1524, ISSN: 1073-449X

RATIONALE: Pulmonary rehabilitation following hospitalizations for exacerbations of chronic obstructive pulmonary disease (COPD) improves exercise capacity and health-related quality of life, and reduces readmissions. However, post-hospitalization pulmonary rehabilitation uptake is low. To date, no trials of interventions to increase uptake have been conducted. OBJECTIVE: Effect of a co-designed education video as an adjunct to usual care on post-hospitalization pulmonary rehabilitation uptake. METHODS: An assessor- and statistician-blinded randomized controlled trial with nested qualitative interviews of participants in the intervention group. Participants hospitalized with COPD exacerbations were assigned 1:1 to receive either usual care (COPD discharge bundle including pulmonary rehabilitation information leaflet) or usual care plus the co-designed education video delivered via a handheld tablet device at discharge. Randomization used minimization to balance age, sex, forced expiratory volume in 1 second (FEV1) % predicted, frailty, transport availability and previous pulmonary rehabilitation experience. MEASUREMENTS AND MAIN RESULTS: The primary outcome was pulmonary rehabilitation uptake within 28 days of hospital discharge. 200 patients were recruited with 196 randomized (51% female, median (interquartile range) FEV1 % predicted 36(27, 48)). Pulmonary rehabilitation uptake was 41% and 34% in the usual care and intervention groups respectively (p=0.37), with no differences in secondary (pulmonary rehabilitation referral and completion) or safety (readmissions and death) endpoints. Six of the fifteen participants interviewed could not recall receiving the video. CONCLUSION: A co-designed education video delivered at hospital discharge did not improve post-hospitalization pulmonary rehabilitation uptake, referral or completion. This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0

Journal article

Lewis A, Nolan CM, Man WDC, Kon SSC, Conway Jet al., 2020, Prognostication in COPD using physical function measures: Let's walk before we run away with conclusions, RESPIRATORY MEDICINE, Vol: 167, ISSN: 0954-6111

Journal article

Pavitt M, Tanner RJ, Lewis A, Buttery S, Mehta B, Jefford H, Curtis KJ, Banya W, Husain S, Satkunam K, Shrikrishna D, Man W, Polkey M, Hopkinson Net al., 2020, Oral nitrate supplementation to enhance pulmonary rehabilitation in COPD: ON-EPIC a multi-centre, double-blind, placebo-controlled, randomised parallel group study, Thorax, Vol: 75, Pages: 547-555, ISSN: 0040-6376

Rationale Dietary nitrate supplementation has been proposed as a strategy to improve exercise performance, both in healthy individuals and in people with chronic obstructive pulmonary disease (COPD). We aimed to assess whether it could enhance the effect of pulmonary rehabilitation (PR) in COPD.Methods This double-blind, placebo-controlled, parallel group, randomised controlled study performed at four UK centres, enrolled adults with GOLD grade II-IV COPD and MRC dyspnoea score 3-5 or functional limitation to undertake a twice weekly eight week PR programme. They were randomly assigned (1:1) to either 140mls of nitrate-rich beetroot juice (BRJ) (12.9mmol nitrate), or placebo nitrate-deplete BRJ, consumed three hours prior to undertaking each PR session. Allocation used computer generated block randomisation. Measurements The primary outcome was change in incremental shuttle walk test (ISWT) distance. Secondary outcomes included quality of life, physical activity level, endothelial function via flow mediated dilatation, fat free mass index and blood pressure parameters.Main Results 165 participants were recruited, 78 randomised to nitrate-rich BRJ and 87 randomised to placebo. Exercise capacity increased more with active treatment (n=57) than placebo (n=65); median (IQR) change in ISWT distance +60m (10, 85) vs. +30m (0, 70), (p = 0.027). Active treatment also impacted on systolic blood pressure: Treatment group -5.0mmHg (-5.0, -3.0) vs control +6.0mmHg (-1.0, 15.5) (p<0.0005). No significant serious adverse events or side effects were reported.Conclusions Dietary nitrate supplementation appears to be a well-tolerated and effective strategy to augment the benefits of PR in COPD.

Journal article

Barker RE, Kon SS, Clarke SF, Sivarajah S, Nolan CM, Jones SE, Patel S, Walsh JA, Polgar O, Maddocks M, Farquhar M, Wedzicha JA, Man Wet al., 2020, Predictors of Pulmonary Rehabilitation Referral and Uptake Following Hospitalization for Exacerbations of COPD: A Cohort Study, International Conference of the American-Thoracic-Society, Publisher: AMER THORACIC SOC, ISSN: 1073-449X

Conference paper

Walsh JA, Nolan CM, Al Abbas MM, Patel S, Barker RE, Polgar O, Kon SSC, Maddocks M, Man WDet al., 2020, Sarcopenia in Chronic Obstructive Pulmonary Disease (COPD): Response to Pulmonary Rehabilitation, International Conference of the American-Thoracic-Society (ATS), Publisher: AMER THORACIC SOC, ISSN: 1073-449X

Conference paper

Patel S, Barker RE, Walsh JA, Polgar O, Maddocks M, Nolan CM, Man Wet al., 2020, Poor Appetite in Chronic Obstructive Pulmonary Disease (COPD): Prevalence and Clinical Correlates, International Conference of the American-Thoracic-Society (ATS), Publisher: AMER THORACIC SOC, ISSN: 1073-449X

Conference paper

Walsh J, Nolan CM, Al Abbas MM, Patel S, Barker RE, Polgar O, Kon SSC, Maddocks M, Man WDet al., 2020, Sarcopenia in Chronic Obstructive Pulmonary Disease (COPD): Prevalence and Clinical Correlates, International Conference of the American-Thoracic-Society (ATS), Publisher: AMER THORACIC SOC, ISSN: 1073-449X

Conference paper

Patel S, Barker RE, Walsh JA, Polgar O, Maddocks M, Nolan CM, Man WDCet al., 2020, Response to Pulmonary Rehabilitation in Patients with Poor Appetite and COPD, International Conference of the American-Thoracic-Society (ATS), Publisher: AMER THORACIC SOC, ISSN: 1073-449X

Conference paper

Brighton LJ, Evans CJ, Man WDC, Maddocks Met al., 2020, Improving Exercise-Based Interventions for People Living with Both COPD and Frailty: A Realist Review, INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, Vol: 15, Pages: 841-855, ISSN: 1178-2005

Journal article

Barker RE, Brighton LJ, Maddocks M, Nolan CM, Patel S, Walsh JA, Polgar O, Wenneberg J, Kon SS, Wedzicha JA, Man W, Farquhar Met al., 2020, Integrating Home-Based Exercise Training with a Hospital at Home Service for Patients Hospitalized with Exacerbations of COPD: An Accelerated Experience-Based Co-Design Study, International Conference of the American-Thoracic-Society, Publisher: AMER THORACIC SOC, ISSN: 1073-449X

Conference paper

Walsh JA, Patel S, Barker RE, Jones SE, Wynne SC, Kon SS-C, Cairn J, Loebinger MR, Wilson R, Man WD-C, Nolan CMet al., 2020, The minimum clinically important difference of the incremental shuttle walk test in bronchiectasis: a prospective cohort study., Annals of the American Thoracic Society, Vol: 17, ISSN: 1546-3222

The incremental shuttle walk test (ISW) is an externally-paced field walking test thatmeasures maximal exercise capacity1 and is widely used in patients with chronic obstructivepulmonary disease (COPD) undergoing pulmonary rehabilitation (PR). Its psychometricproperties, including reliability, construct validity2 and responsiveness to intervention,2-5have been demonstrated in patients with bronchiectasis, but little data exist on theminimum clinically important difference (MCID). Although two studies have investigated theMCID of ISW in patients with bronchiectasis, the generalisability of these data is limitedbecause of the study sample characteristics,6 or did not involve an exercise-basedintervention.2 The MCID enables clinicians and researchers to understand the clinicalsignificance of change data and forms an important part of the evidence required byregulatory agencies for approval for use in clinical trials. Accordingly, the aim of this studywas to provide MCID estimates of the ISW in response to intervention, namely PR, inpatients with bronchiectasis.

Journal article

Kwan HY, Maddocks M, Nolan CM, Jones SE, Patel S, Barker RE, Kon SSC, Polkey MI, Cullinan P, Man WD-Cet al., 2019, The prognostic significance of weight loss in chronic obstructive pulmonary disease-related cachexia: a prospective cohort study., Journal of Cachexia, Sarcopenia and Muscle, Vol: 10, Pages: 1330-1338, ISSN: 2190-6009

BACKGROUND: Cachexia is an important extra-pulmonary manifestation of chronic obstructive pulmonary disease (COPD) presenting as unintentional weight loss and altered body composition. Previous studies have focused on the relative importance of body composition compared with body mass rather than the relative importance of dynamic compared with static measures. We aimed to determine the prevalence of cachexia and pre-cachexia phenotypes in COPD and examine the associations between cachexia and its component features with all-cause mortality. METHODS: We enrolled 1755 consecutive outpatients with stable COPD from two London centres between 2012 and 2017, stratified according to European Respiratory Society Task Force defined cachexia [unintentional weight loss >5% and low fat-free mass index (FFMI)], pre-cachexia (weight loss >5% but preserved FFMI), or no cachexia. The primary outcome was all-cause mortality. We calculated hazard ratios (HRs) using Cox proportional hazards regression for cachexia classifications (cachexia, pre-cachexia, and no cachexia) and component features (weight loss and FFMI) and mortality, adjusting for age, sex, body mass index, and disease-specific prognostic markers. RESULTS: The prevalence of cachexia was 4.6% [95% confidence interval (CI): 3.6-5.6] and pre-cachexia 1.6% (95% CI: 1.0-2.2). Prevalence was similar across sexes but increased with worsening Global Initiative for Chronic Obstructive Pulmonary Disease spirometric stage and Medical Research Council dyspnoea score (all P < 0.001). There were 313 (17.8%) deaths over a median (interquartile range) follow-up duration 1089 (547-1704) days. Both cachexia [HR 1.98 (95% CI: 1.31-2.99), P = 0.002] and pre-cachexia [HR 2.79 (95% CI: 1.48-5.29), P = 0.001] were associated with increased mortality. In multivariable analysis, the unintentional weight loss feature of cachexia was independently associated with mortality [HR 2.16 (95% CI: 1.31-3.08), P&nbs

Journal article

Evans RA, Greening NJ, Bolton CE, Singh SJ, Man WD, Steiner MCet al., 2019, What influences the survival advantage following Pulmonary Rehabilitation in patients with COPD?, European-Respiratory-Society (ERS) International Congress, Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936

Conference paper

Alotaibi T, Orme M, Nolan C, Ward T, Chaplin E, Horton E, Harvey-Dunstan T, Man W, Stensel D, Singh Set al., 2019, Profiling changes in physical activity and exercise capacity following lifestyle interventions in COPD, European-Respiratory-Society (ERS) International Congress, Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936

Conference paper

Alotaibi T, Orme M, Nolan C, Ward T, Chaplin E, Horton E, Harvey-Dunstan T, Man W, Stensel D, Singh Set al., 2019, Predicting change in physical activity for individuals with COPD following lifestyle interventions, European-Respiratory-Society (ERS) International Congress, Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936

Conference paper

Wynne S, Patel S, Barker RE, Jones SE, Walsh JA, Kon SS, Cairn J, Loebinger MR, Wilson R, Man WD, Nolan CMet al., 2019, The Hospital Anxiety and Depression Scale (HADS) in Bronchiectasis: Response to pulmonary rehabilitation (PR) and Minimum Clinically Important Difference (MCID), European-Respiratory-Society (ERS) International Congress, Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936

Conference paper

Jones A, Evans R, Man W, bolton C, breen S, doherty P, gardiner N, Houchen- Wolloff L, hurst J, maddocks M, Quint J, jolly K, revitt O, sherar L, watt A, wingham J, yorke J, singh Set al., 2019, Outcome measures in a combined exercise rehabilitation programme for COPD and chronic heart failure patients: a stakeholder consensus event, Chronic Respiratory Disease, Vol: 16, ISSN: 1479-9723

Combined exercise rehabilitation for chronic obstructive pulmonary disease (COPD) and chronic heart failure (CHF) is potentially attractive. Uncertainty remains as to the baseline profiling assessments and outcome measures that should be collected within a programme. Current evidence surrounding outcome measures in cardiac and pulmonary rehabilitation were presented by experts at a stakeholder consensus event and all stakeholders (n = 18) were asked to (1) rank in order of importance a list of categories, (2) prioritise outcome measures and (3) prioritise baseline patient evaluation measures that should be assessed in a combined COPD and CHF rehabilitation programme. The tasks were completed anonymously and related to clinical rehabilitation programmes and associated research. Health-related quality of life, exercise capacity and symptom evaluation were voted as the most important categories to assess for clinical purposes (median rank: 1, 2 and 3 accordingly) and research purposes (median rank; 1, 3 and 4.5 accordingly) within combined exercise rehabilitation. All stakeholders agreed that profiling symptoms at baseline were ‘moderately’, ‘very’ or ‘extremely’ important to assess for clinical and research purposes in combined rehabilitation. Profiling of frailty was ranked of the same importance for clinical purposes in combined rehabilitation. Stakeholders identified a suite of multidisciplinary measures that may be important to assess in a combined COPD and CHF exercise rehabilitation programme.

Journal article

This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.

Request URL: http://wlsprd.imperial.ac.uk:80/respub/WEB-INF/jsp/search-html.jsp Request URI: /respub/WEB-INF/jsp/search-html.jsp Query String: respub-action=search.html&id=00358560&limit=30&person=true