Imperial College London
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DrWilliamMan

Faculty of Medicine, National Heart & Lung Institute

Reader in Respiratory Medicine
 
 
 
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+44 (0)1895 828 851w.man

 
 
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Location

 

Harefield HospitalHarefield Hospital

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Summary

 

Publications

Citation

BibTex format

@article{Nolan:2022:10.1016/j.chest.2021.10.021,
author = {Nolan, CM and Polgar, O and Schofield, SJ and Patel, S and Barker, RE and Walsh, JA and Ingram, KA and George, PM and Molyneaux, PL and Maher, TM and Man, WD-C},
doi = {10.1016/j.chest.2021.10.021},
journal = {Chest},
pages = {728--737},
title = {Pulmonary rehabilitation in idiopathic pulmonary fibrosis and COPD: a propensity matched real-world study},
url = {http://dx.doi.org/10.1016/j.chest.2021.10.021},
volume = {161},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: The adherence to and clinical efficacy of pulmonary rehabilitation in idiopathic pulmonary fibrosis (IPF), particularly in comparison to people with chronic obstructive pulmonary disease (COPD), remains uncertain. The objectives of this real-world study were to compare the responses of patients with IPF with a matched group of patients with COPD undergoing the same supervised, outpatient pulmonary rehabilitation program, and to determine whether pulmonary rehabilitation is associated with survival in IPF. RESEARCH QUESTION: Do people with IPF improve to the same extent with pulmonary rehabilitation as a matched group of individuals with COPD, and are non-completion of and/or non-response to pulmonary rehabilitation associated with one-year all-cause mortality in IPF? STUDY DESIGN AND METHODS: Using propensity score matching, 163 patients with IPF were matched 1:1 with a control group of 163 patients with COPD referred to pulmonary rehabilitation. We compared between-group pulmonary rehabilitation completion rates and response. Survival status in the IPF cohort was recorded over one-year following pulmonary rehabilitation discharge. Cox proportional-hazards regression explored the association between pulmonary rehabilitation status and all-cause mortality. RESULTS: Similar pulmonary rehabilitation completion rates (IPF: 69%; COPD: 63%; p=0.24) and improvements in exercise response were observed in both groups with no significant mean (95% confidence interval (CI)) between-group differences in incremental shuttle walk (ISW) change (2 (-18 to 22) meters). Pulmonary rehabilitation non-completion (hazard ratio (HR) (95%CI) 5.62 (2.24 to 14.08)) and non-response (HR (95%CI) 3.91 (1.54 to 9.93)) were independently associated with increased one-year all-cause mortality in IPF. INTERPRETATION: Compared with a matched group of patients with COPD, this real-word study demonstrates that patients with IPF have similar completion rates and magnitude of response to pul
AU  - Nolan,CM
AU  - Polgar,O
AU  - Schofield,SJ
AU  - Patel,S
AU  - Barker,RE
AU  - Walsh,JA
AU  - Ingram,KA
AU  - George,PM
AU  - Molyneaux,PL
AU  - Maher,TM
AU  - Man,WD-C
DO  - 10.1016/j.chest.2021.10.021
EP  - 737
PY  - 2022///
SN  - 0012-3692
SP  - 728
TI  - Pulmonary rehabilitation in idiopathic pulmonary fibrosis and COPD: a propensity matched real-world study
T2  - Chest
UR  - http://dx.doi.org/10.1016/j.chest.2021.10.021
UR  - https://www.ncbi.nlm.nih.gov/pubmed/34699771
UR  - http://hdl.handle.net/10044/1/92677
VL  - 161
ER  -
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