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@article{Brighton:2023:10.2147/COPD.S375142,
author = {Brighton, LJ and Nolan, CM and Barker, RE and Patel, S and Walsh, JA and Polgar, O and Kon, SSC and Gao, W and Evans, CJ and Maddocks, M and Man, WDC},
doi = {10.2147/COPD.S375142},
journal = {The International Journal of Chronic Obstructive Pulmonary Disease},
pages = {57--67},
title = {Frailty and mortality risk in COPD: a cohort study comparing the fried frailty phenotype and short physical performance battery},
url = {http://dx.doi.org/10.2147/COPD.S375142},
volume = {18},
year = {2023}
}

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TY  - JOUR
AB  - Background: Identifying frailty in people with chronic obstructive pulmonary disease (COPD) is deemed important, yet comparative characteristics of the most commonly used frailty measures in COPD are unknown. This study aimed to compare how the Fried Frailty Phenotype (FFP) and Short Physical Performance Battery (SPPB) characterise frailty in people with stable COPD, including prevalence of and overlap in identification of frailty, disease and health characteristics of those identified as living with frailty, and predictive value in relation to survival time.Methods: Cohort study of people with stable COPD attending outpatient clinics. Agreement between frailty classifications was described using Cohen’s Kappa. Disease and health characteristics of frail versus not frail participants were compared using t-, Mann–Whitney U and Chi-Square tests. Predictive value for mortality was examined with multivariable Cox regression.Results: Of 714 participants, 421 (59%) were male, mean age 69.9 years (SD 9.7), mean survival time 2270 days (95% CI 2185– 2355). Similar proportions were identified as frail using the FFP (26.2%) and SPPB (23.7%) measures; classifications as frail or not frail matched in 572 (80.1%) cases, showing moderate agreement (Kappa = 0.469, SE = 0.038, p < 0.001). Discrepancies seemed driven by FFP exhaustion and weight loss criteria and the SPPB balance component. People with frailty by either measure had worse exercise capacity, health-related quality of life, breathlessness, depression and dependence in activities of daily living. In multivariable analysis controlling for the Age Dyspnoea Obstruction index, sex, BMI, comorbidities and exercise capacity, both the FFP and SPPB had predictive value in relation to mortality (FFP aHR = 1.31 [95% CI 1.03– 1.66]; SPPB aHR = 1.29 [95% CI 0.99– 1.68]).Conclusion: In stable COPD, both the FFP and SPPB identify similar proportions of people living with/without frailty, the majority
AU  - Brighton,LJ
AU  - Nolan,CM
AU  - Barker,RE
AU  - Patel,S
AU  - Walsh,JA
AU  - Polgar,O
AU  - Kon,SSC
AU  - Gao,W
AU  - Evans,CJ
AU  - Maddocks,M
AU  - Man,WDC
DO  - 10.2147/COPD.S375142
EP  - 67
PY  - 2023///
SN  - 1176-9106
SP  - 57
TI  - Frailty and mortality risk in COPD: a cohort study comparing the fried frailty phenotype and short physical performance battery
T2  - The International Journal of Chronic Obstructive Pulmonary Disease
UR  - http://dx.doi.org/10.2147/COPD.S375142
UR  - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000923540300001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=a2bf6146997ec60c407a63945d4e92bb
UR  - https://www.dovepress.com/frailty-and-mortality-risk-in-copd-a-cohort-study-comparing-the-fried--peer-reviewed-fulltext-article-COPD
UR  - http://hdl.handle.net/10044/1/107317
VL  - 18
ER  -

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