Imperial College London

Prof. William Wisden F. Med. Sci.

Faculty of Natural SciencesDepartment of Life Sciences

Chair in Molecular Neuroscience



+44 (0)20 7594 9744w.wisden Website CV




401BSir Ernst Chain BuildingSouth Kensington Campus





Research interests and techniques

    AAV infected subicular neurons, Dr A. Zecharia
  • Neuroscience: molecular biology; transgenics, neuroanatomy, physiology, behaviour. 
  • Mechanisms of sleep
  • Hypothalamic function: the regulation of neurons which make histamine: the tuberomammillary nucleus and sleep regulation
  • other neuromodulators which regulate sleep



1986 BA,  Zoology - Natural Sciences, University of Cambridge
1989 PhD Molecular Neuroscience, University of Cambridge (with Stephen P. Hunt).

Posts held:

1990-1992 EMBO Long-term Fellowship, ZMBH, University of Heidelberg (with Peter H. Seeburg)
1993-2001 Group Leader, MRC LMB, Cambridge
2001-2005 Group Leader, IZN, University of Heidelberg
2005-2009 Professor & Chair of Neuroscience, Head of Neurobiology programme, Institute of Medical Sciences, University of Aberdeen

2009- Professor of Molecular Neuroscience



How to find us: click here for a map  - we are on the 4th floor  of the Sir Ernst Chain Building (marked "30" on the map)

Imperial College''s location in London:

 Royal Albert Hall - next to Imperial College

 Albert Hall - view from Imperial






Yu X, Ma Y, Harding EC, et al., 2019, Corrigendum: Genetic lesioning of histamine neurons increases sleep-wake fragmentation and reveals their contribution to modafinil-induced wakefulness., Sleep, Vol:42

Ma Y, Miracca G, Yu X, et al., Galanin neurons unite sleep homeostasis and alpha2 adrenergic sedation, Current Biology, ISSN:1879-0445

Yu X, Ba W, Zhao G, et al., 2019, Dysfunction of ventral tegmental area GABA neurons causes mania-like behavior,

Harding E, Franks N, Wisden W, 2019, The temperature dependence of sleep, Frontiers in Neuroscience, Vol:13, ISSN:1662-4548


Hsieh B, Harding E, Wisden W, et al., A Miniature Neural Recording Device to Investigate Sleep and Temperature Regulation in Mice, IEEE Biomedical Circuits and Systems (BioCAS) Conference

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