Summary
Neuronal Circuitry of Sleep
https://www.franks-wisden-lab.org/
Why we spend one third of our lives in a state of vulnerable inactivity – sleep – is an enduring mystery. Like hunger and thirst, the urge to sleep is a primal biological drive. It builds during waking and then dissipates during sleep. But the question of what exactly the drive to sleep is remains unsolved. In fact the drive to sleep after prolonged sleep deprivation seems so strong that it is similar to taking a sedative drug. We are investigating the mechanisms underlying the sleep drive and asking whether certain sedatives produce unconsciousness by activating the same neuronal pathways. Using a genetic approach that 'tags' the neurons involved, we aim to find out how these circuits function. A deeper knowledge of how sedatives work could lead to drugs that have fewer side effects and might even give the restorative benefits of natural sleep. Specifically, the Franks-Wisden lab aims to understand:
1) What circuitries sense the inexorable drive to sleep when we are sleep-deprived (sleep homeostasis), and once initiated, how is sleep maintained? (Wellcome Trust Investigator Award).
2) Do sedative drugs promote these restorative sleep pathways? (Wellcome Trust Investigator Award).
3) Does sleep promote the clearance of waste metabolites? (UK DRI funded)
Publications and ORCID PROFILE:
- See William Wisden's publications on PubMed
- See William Wisden's publications on Google Scholar
- See William Wisden's profile on ORCID
I share my lab and research programme with Prof. Nick Franks
Degrees:
1986 BA, Zoology - Natural Sciences, University of Cambridge
1989 PhD Molecular Neuroscience, University of Cambridge (with Stephen P. Hunt).
Posts held:
1990-1992 EMBO Long-term Fellowship, ZMBH, University of Heidelberg (with Peter H. Seeburg)
1993-2001 Group Leader, MRC LMB, Cambridge
2001-2005 Group Leader, IZN, University of Heidelberg
2005-2009 Professor & Chair of Neuroscience, Institute of Medical Sciences, University of Aberdeen
2009- Professor of Molecular Neuroscience at Imperial College
Member of UK Dementia Research Institute at Imperial College
Co-Director, Centre for Neurotechnology
Location
How to find us: click here for a map - we are in the Sir Ernst Chain Building.
Imperial College's location in London:
Royal Albert Hall - next to Imperial College
Publications
Journals
Miracca G, Soto BA, Tossell K, et al., 2020, Hypothalamic NMDA receptors stabilize NREM sleep and are essential for REM sleep
Tossell K, Yu X, Soto BA, et al., 2020, Sleep deprivation triggers somatostatin neurons in prefrontal cortex to initiate nesting and sleep via the preoptic and lateral hypothalamus
Yu X, Ba W, Zhao G, et al., 2020, Dysfunction of ventral tegmental area GABA neurons causes mania-like behavior., Molecular Psychiatry, ISSN:1359-4184
Harding E, Franks N, Wisden W, 2020, Sleep and thermoregulation, Current Opinion in Physiology, Vol:15, ISSN:2468-8673, Pages:7-13
Conference
Lignos L, Nollet M, Wisden W, et al., 2020, Does sleep deprivation cause stress in mice? A comparison of gentle handling versus novel object presentation sleep deprivation methods, 25th Congress of the European-Sleep-Research-Society (ESRS), WILEY, Pages:195-196, ISSN:0962-1105