Summary
Neuronal Circuitry of Sleep
https://www.franks-wisden-lab.org/
Why we spend one third of our lives in a state of vulnerable inactivity – sleep – is an enduring mystery. Like hunger and thirst, the urge to sleep is a primal biological drive. It builds during waking and then dissipates during sleep. But the question of what exactly the drive to sleep is remains unsolved. In fact the drive to sleep after prolonged sleep deprivation seems so strong that it is similar to taking a sedative drug. We are investigating the mechanisms underlying the sleep drive and asking whether certain sedatives produce unconsciousness by activating the same neuronal pathways. Using a genetic approach that 'tags' the neurons involved, we aim to find out how these circuits function. A deeper knowledge of how sedatives work could lead to drugs that have fewer side effects and might even give the restorative benefits of natural sleep. Specifically, the Franks-Wisden lab aims to understand:
1) What circuitries sense the inexorable drive to sleep when we are sleep-deprived (sleep homeostasis), and once initiated, how is sleep maintained? (Wellcome Trust Investigator Award).
2) Do sedative drugs promote these restorative sleep pathways? (Wellcome Trust Investigator Award).
3) Does sleep promote the clearance of waste metabolites? (UK DRI funded)
Publications and ORCID PROFILE:
- See William Wisden's publications on PubMed
- See William Wisden's publications on Google Scholar
- See William Wisden's profile on ORCID
I share my lab and research programme with Prof. Nick Franks
Degrees:
1986 BA, Zoology - Natural Sciences, University of Cambridge
1989 PhD Molecular Neuroscience, University of Cambridge (with Stephen P. Hunt).
Posts held:
1990-1992 EMBO Long-term Fellowship, ZMBH, University of Heidelberg (with Peter H. Seeburg)
1993-2001 Group Leader, MRC LMB, Cambridge
2001-2005 Group Leader, IZN, University of Heidelberg
2005-2009 Professor & Chair of Neuroscience, Institute of Medical Sciences, University of Aberdeen
2009- Professor of Molecular Neuroscience at Imperial College
Member of UK Dementia Research Institute at Imperial College
Co-Director, Centre for Neurotechnology
Location
How to find us: click here for a map - we are in the Sir Ernst Chain Building.
Publications
Journals
Wisden W, Franks NP, 2023, Biochemical pathways of sleep., Cell Res
Brickley S, Lucaci D, Yu X, et al., 2022, Histamine release in the prefrontal cortex excites fast-spiking interneurons while GABA released from the same axons inhibits pyramidal cells., The Journal of Neuroscience, ISSN:0270-6474
Yu X, Zhao G, Wang D, et al., 2022, A specific circuit in the midbrain detects stress and induces restorative sleep, Science, Vol:377, ISSN:1095-9203, Pages:1-10
Miracca G, Anuncibay Soto B, Tossell K, et al., 2022, NMDA receptors in the lateral preoptic hypothalamus are essential for sustaining NREM and REM sleep, The Journal of Neuroscience, Vol:42, ISSN:0270-6474, Pages:5389-5409
Conference
Tossell K, Yu X, Soto BA, et al., 2022, NEURONS IN PREFRONTAL CORTEX RESPOND TO SLEEP DEPRIVATION BY INITIATING SLEEP PREPARATORY BEHAVIOUR AND NREM SLEEP, ELSEVIER, Pages:S20-S20, ISSN:1389-9457