Imperial College London

Prof. William Wisden F. Med. Sci.

Faculty of Natural SciencesDepartment of Life Sciences

Chair in Molecular Neuroscience



+44 (0)20 7594 9744w.wisden Website CV




401BSir Ernst Chain BuildingSouth Kensington Campus





Research interests and techniques

    AAV infected subicular neurons, Dr A. Zecharia
  • Neuroscience: molecular biology; transgenics, neuroanatomy, physiology, behaviour. 
  • Mechanisms of sleep
  • Hypothalamic function: the regulation of neurons which make histamine: the tuberomammillary nucleus and sleep regulation
  • other neuromodulators which regulate sleep



1986 BA,  Zoology - Natural Sciences, University of Cambridge
1989 PhD Molecular Neuroscience, University of Cambridge (with Stephen P. Hunt).

Posts held:

1990-1992 EMBO Long-term Fellowship, ZMBH, University of Heidelberg (with Peter H. Seeburg)
1993-2001 Group Leader, MRC LMB, Cambridge
2001-2005 Group Leader, IZN, University of Heidelberg
2005-2009 Professor & Chair of Neuroscience, Head of Neurobiology programme, Institute of Medical Sciences, University of Aberdeen

2009- Professor of Molecular Neuroscience



How to find us: click here for a map  - we are on the 4th floor  of the Sir Ernst Chain Building (marked "30" on the map)

Imperial College''s location in London:

 Royal Albert Hall - next to Imperial College

 Albert Hall - view from Imperial






Harding E, Franks N, Wisden W, 2019, The temperature dependence of sleep, Frontiers in Neuroscience, Vol:13, ISSN:1662-4548

Yu X, Ma Y, Harding E, et al., 2019, Genetic lesioning of histamine neurons increases sleep-wake fragmentation and reveals their contribution to modafinil-induced wakefulness, Sleep, ISSN:1550-9109

Yu X, Li W, Ma Y, et al., 2019, GABA and glutamate neurons in the VTA regulate sleep and wakefulness, Nature Neuroscience, Vol:22, ISSN:1097-6256, Pages:106-119

Paul EJ, Kalk E, Tossell K, et al., 2018, nNOS-expressing neurons in the ventral tegmental area and substantia nigra pars compacta, Eneuro, Vol:5, ISSN:2373-2822

Wisden W, Franks NP, Scammell TE, et al., 2018, Histamine: neural circuits and new medications, Sleep, ISSN:1550-9109

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