Imperial College London

Prof. William Wisden F. Med. Sci.

Faculty of Natural SciencesDepartment of Life Sciences

Chair in Molecular Neuroscience
 
 
 
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Contact

 

+44 (0)20 7594 9744w.wisden Website CV

 
 
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Location

 

401BSir Ernst Chain BuildingSouth Kensington Campus

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Summary

 

Publications

Publication Type
Year
to

194 results found

Seja P, Schonewille M, Spitzmaul G, Badura A, Klein I, Rudhard Y, Wisden W, Huebner CA, De Zeeuw CI, Jentsch TJet al., 2012, Raising cytosolic Cl- in cerebellar granule cells affects their excitability and vestibulo-ocular learning, EMBO JOURNAL, Vol: 31, Pages: 1217-1230, ISSN: 0261-4189

Journal article

Leppa E, Linden A-M, Vekovischeva OY, Swinny JD, Rantanen V, Toppila E, Hoeger H, Sieghart W, Wulff P, Wisden W, Korpi ERet al., 2011, Removal of GABA(A) Receptor gamma 2 Subunits from Parvalbumin Neurons Causes Wide-Ranging Behavioral Alterations, PLOS ONE, Vol: 6, ISSN: 1932-6203

Journal article

Leppa E, Linden A-M, Rabe H, Vekovischeva OY, Wulff P, Lueddens H, Wisden W, Korpi ERet al., 2011, Actions of two GABA(A) receptor benzodiazepine-site ligands that are mediated via non-gamma 2-dependent modulation, EUROPEAN JOURNAL OF PHARMACOLOGY, Vol: 666, Pages: 111-121, ISSN: 0014-2999

Journal article

Murray AJ, Sauer J-F, Riedel G, McClure C, Ansel L, Cheyne L, Bartos M, Wisden W, Wulff Pet al., 2011, Parvalbumin-positive CA1 interneurons are required for spatial working but not for reference memory, NATURE NEUROSCIENCE, Vol: 14, Pages: 297-299, ISSN: 1097-6256

Journal article

Linden A-M, Schmitt U, Leppa E, Wulff P, Wisden W, Lueddens H, Korpi ERet al., 2011, Ro 15-4513 antagonizes alcohol-induced sedation in mice through alpha beta gamma 2-type GABA(A) receptors, FRONTIERS IN NEUROSCIENCE, Vol: 5, ISSN: 1662-453X

Journal article

Engelhardt T, Wisden W, 2011, Central nervous system: neurotransmitters and anesthesia, Pediatric Anesthesia: Basic principles - state of the art - future, Editors: Bissonnette, Anderson, Boesenberg, Engelhardt, Mason, Tobias, Shelton, Connecticut, USA, Publisher: People's Medical publishing House -USA, Pages: 71-79, ISBN: 978-1-60795-093-6

Book chapter

Muhammad S, Aller MI, Maser-Gluth C, Schwaninger M, Wisden Wet al., 2010, EXPRESSION OF THE KCNK3 POTASSIUM CHANNEL GENE LESSENS THE INJURY FROM CEREBRAL ISCHEMIA, MOST LIKELY BY A GENERAL INFLUENCE ON BLOOD PRESSURE, NEUROSCIENCE, Vol: 167, Pages: 758-764, ISSN: 0306-4522

Journal article

Heimann D, Bandulik S, Penton D, Lesage F, Wisden W, Barhanin J, Warth Ret al., 2010, The role of TASK potassium channels in the control of aldosterone secretion, ENDOCRINE JOURNAL, Vol: 57, Pages: S276-S276, ISSN: 0918-8959

Journal article

Wisden W, 2010, Cre-ating ways to serotonin, FRONTIERS IN NEUROSCIENCE, Vol: 4, ISSN: 1662-453X

Journal article

Wisden W, Meier JC, 2010, Genetic techniques and circuit analysis., Front Mol Neurosci, Vol: 3, ISSN: 1662-5099

Journal article

Pang DSJ, Robledo CJ, Carr DR, Gent TC, Vyssotski AL, Caley A, Zecharia AY, Wisden W, Brickley SG, Franks NPet al., 2009, An unexpected role for TASK-3 potassium channels in network oscillations with implications for sleep mechanisms and anesthetic action, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 106, Pages: 17546-17551, ISSN: 0027-8424

Journal article

Donner B, Schullenberg M, Huning A, Decking U, Kovacevic A, Wisden W, Schmidt KGet al., 2009, Cardiac phenotyping the TASK-1 deficient mouse, CLIN RES CARDIOL, Vol: 98, Pages: 589-589, ISSN: 1861-0684

Journal article

Wulff P, Schonewille M, Renzi M, Viltono L, Sassoe-Pognetto M, Badura A, Gao Z, Hoebeek FE, van Dorp S, Wisden W, Farrant M, De Zeeuw CIet al., 2009, Synaptic inhibition of Purkinje cells mediates consolidation of vestibulo-cerebellar motor learning, NATURE NEUROSCIENCE, Vol: 12, Pages: 1042-U118, ISSN: 1097-6256

Journal article

Wulff P, Ponomarenko AA, Bartos M, Korotkova TM, Fuchs EC, Baehner F, Both M, Tort ABL, Kopell NJ, Wisden W, Monyer Het al., 2009, Hippocampal theta rhythm and its coupling with gamma oscillations require fast inhibition onto parvalbumin-positive interneurons, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 106, Pages: 3561-3566, ISSN: 0027-8424

Journal article

Murray A, Black C, Cheyne L, Riedel G, Wisden W, Wulff Pet al., 2009, Selective modulation of parvalbumin GABAergic interneuron function in-vivo in mice, European-College-of-Neuropsychopharmacology Workshop on Neuropsychopharmacology for Young Scientists in Europe, Publisher: ELSEVIER SCIENCE BV, Pages: S20-S21, ISSN: 0924-977X

Conference paper

Murray A, Black C, Cheyne L, Riedel G, Wisden W, Wulff Pet al., 2009, P.1.22 Selective modulation of parvalbumin GABAergic interneuron function in-vivo in mice, European Neuropsychopharmacology, Vol: 19, Pages: S20-S21, ISSN: 0924-977X

Journal article

Wisden W, 2009, Engineering receptor subtypes as tools in neuropsychopharmacology, European-College-of-Neuropsychopharmacology Workshop on Neuropsychopharmacology for Young Scientists in Europe, Publisher: ELSEVIER SCIENCE BV, Pages: S2-S3, ISSN: 0924-977X

Conference paper

Wisden W, 2009, S.1.02 Engineering receptor subtypes as tools in neuropsychopharmacology, European Neuropsychopharmacology, Vol: 19, Pages: S2-S3, ISSN: 0924-977X

Journal article

Gajendran N, Kapfhammer JP, Lain E, Canepari M, Vogt K, Wisden W, Brenner HRet al., 2009, Neuregulin Signaling Is Dispensable for NMDA- and GABA(A)-Receptor Expression in the Cerebellum In Vivo, JOURNAL OF NEUROSCIENCE, Vol: 29, Pages: 2404-2413, ISSN: 0270-6474

Journal article

Goetz T, Wulff P, Wisden W, 2009, GABA<inf>A</inf> Receptors: Molecular Biology, Cell Biology, and Pharmacology, Pages: 463-470

Γ-Aminobutyric acid A (GABAA) receptors are the principal means of delivering fast (millisecond) inhibition to neurons in the vertebrate central nervous system. The receptors are ligand-gated chloride channels in the nicotinic acetylcholine receptor superfamily. On the binding of two GABA molecules, a conformational change occurs, and Cl? moves into the cell, producing an inhibitory hyperpolarization. Drugs acting at the GABAA receptor are used widely in medicine, such as for the induction and maintenance of general anesthesia or to treat anxiety disorders, states of agitation, epilepsy, or sleep disorders. There is scope to develop these drugs further so that they produce fewer side effects. © 2009 Elsevier Ltd All rights reserved.

Journal article

Wisden W, Murray AJ, McClure C, Wulff Pet al., 2009, Studying Cerebellar Circuits by Remote Control of Selected Neuronal Types with GABA(A) Receptors., Front Mol Neurosci, Vol: 2

Although GABA(A) receptor-mediated inhibition of cerebellar Purkinje cells by molecular layer interneurons (MLIs) has been studied intensely at the cellular level, it has remained unclear how this inhibition regulates cerebellum-dependent behaviour. We have implemented two complementary approaches to investigate the function of the MLI-Purkinje cell synapse on the behavioural level. In the first approach we permanently disrupted inhibitory fast synaptic transmission at the synapse by genetically removing the postsynaptic GABA(A) receptors from Purkinje cells (PC-Deltagamma2 mice). We found that chronic disruption of the MLI-Purkinje cell synapse strongly impaired cerebellar learning of the vestibular occular reflex (VOR), presumably by disrupting the temporal patterns of Purkinje cell activity. However, in PC-Deltagamma2 mice the baseline VOR reflex was only mildly affected; indeed PC-Deltagamma2 mice show no ataxia or gait abnormalities, suggesting that MLI control of Purkinje cell activity is either not involved in ongoing motor tasks or that the system compensates for its loss. To investigate the latter possibility we developed an alternative genetic technique; we made the MLI-Purkinje cell synapse selectively sensitive to rapid manipulation with the GABA(A) receptor modulator zolpidem (PC-gamma2-swap mice). Minutes after intraperitoneal zolpidem injection, these PC-gamma2-swap mice developed severe motor abnormalities, revealing a substantial contribution of the MLI-Purkinje cell synapses to real time motor control. The cell-type selective permanent knockout of synaptic GABAergic input and the fast reversible modulation of GABAergic input at the same synapse illustrate how pursuing both strategies gives a fuller view.

Journal article

Linden A-M, Aller MI, Leppa E, Rosenberg PH, Wisden W, Korpi ERet al., 2008, K+ channel TASK-1 knockout mice show enhanced sensitivities to ataxic and hypnotic effects of GABA(A) receptor ligands, JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, Vol: 327, Pages: 277-286, ISSN: 0022-3565

Journal article

Trapp S, Aller MI, Wisden W, Gourine AVet al., 2008, A role for TASK-1 (KCNK3) channels in the chemosensory control of breathing, JOURNAL OF NEUROSCIENCE, Vol: 28, Pages: 8844-8850, ISSN: 0270-6474

Journal article

Aller MI, Wisden W, 2008, Changes in expression of some two-pore domain potassium channel genes (KCNK) in selected brain regions of developing mice, NEUROSCIENCE, Vol: 151, Pages: 1154-1172, ISSN: 0306-4522

Journal article

Heitzmann D, Derand R, Jungbauer S, Bandulik S, Sterner C, Schweda F, El Wakil A, Lalli E, Guy N, Mengual R, Reichold M, Tegtmeier I, Bendahhou S, Gomez-Sanchez CE, Aller MI, Wisden W, Weber A, Lesage F, Warth R, Barhanin Jet al., 2008, Invalidation of TASK1 potassium channels disrupts adrenal gland zonation and mineralocorticoid homeostasis, EMBO JOURNAL, Vol: 27, Pages: 179-187, ISSN: 0261-4189

Journal article

Peterschmitt Y, Weger S, Plauth A, Heilbronn R, Wisden W, Sperk G, Sieghart Wet al., 2008, Establishing a new mouse model for investigating the function of amygdala neurons in anxiety, BMC Pharmacology, Vol: 8, Pages: A35-A35, ISSN: 1471-2210

Journal article

Wisden W, 2008, Commissioned meeting report: Glutamate and GABAA receptors – a BNA conference, Durham, UK, 9th April 2008., The Investigational drugs database Alerts (IDdb Alerts)

Journal article

Linden A-M, Sandu C, Aller MI, Vekovischeva OY, Rosenberg PH, Wisden W, Korpi ERet al., 2007, TASK-3 knockout mice exhibit exaggerated nocturnal activity, impairments in cognitive functions, and reduced sensitivity to inhalation Anesthetics, JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, Vol: 323, Pages: 924-934, ISSN: 0022-3565

Journal article

Wulff P, Goetz T, Leppä E, Linden AM, Renzi M, Swinny JD, Vekovischeva OY, Sieghart W, Somogyi P, Korpi ER, Farrant M, Wisden Wet al., 2007, From synapse to behavior: Rapid modulation of defined neuronal types with engineered GABA<inf>A</inf> receptors, Neuroforum, Vol: 13, Pages: 134-136, ISSN: 0947-0875

Journal article

Brickley SG, Aller MI, Sandu C, Veale EL, Alder FG, Sambi H, Mathie A, Wisden Wet al., 2007, TASK-3 two-pore domain potassium channels enable sustained high-frequency firing in cerebellar granule neurons, JOURNAL OF NEUROSCIENCE, Vol: 27, Pages: 9329-9340, ISSN: 0270-6474

Journal article

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