Imperial College London

Prof. William Wisden F. Med. Sci.

Faculty of Natural SciencesDepartment of Life Sciences

Chair in Molecular Neuroscience
 
 
 
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Contact

 

+44 (0)20 7594 9744w.wisden Website CV

 
 
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Location

 

401BSir Ernst Chain BuildingSouth Kensington Campus

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Summary

 

Publications

Publication Type
Year
to

200 results found

Baker R, Gent TC, Yang Q, Parker S, Vyssotski AL, Wisden W, Brickley SG, Franks NPet al., 2014, Altered Activity in the Central Medial Thalamus Precedes Changes in the Neocortex during Transitions into Both Sleep and Propofol Anesthesia, JOURNAL OF NEUROSCIENCE, Vol: 34, Pages: 13326-13335, ISSN: 0270-6474

Journal article

Gelegen C, Gent TC, Ferretti V, Zhang Z, Yustos R, Lan F, Yang Q, Overington DWU, Vyssotski AL, van Lith HA, Wisden W, Franks NPet al., 2014, Staying awake - a genetic region that hinders alpha(2) adrenergic receptor agonist-induced sleep, EUROPEAN JOURNAL OF NEUROSCIENCE, Vol: 40, Pages: 2311-2319, ISSN: 0953-816X

Journal article

Galliano E, Potters J-W, Elgersma Y, Wisden W, Kushner SA, De Zeeuw CI, Hoebeek FEet al., 2013, Synaptic Transmission and Plasticity at Inputs to Murine Cerebellar Purkinje Cells Are Largely Dispensable for Standard Nonmotor Tasks, JOURNAL OF NEUROSCIENCE, Vol: 33, Pages: 12599-12618, ISSN: 0270-6474

Journal article

Frola E, Patrizi A, Goetz T, Medrihan L, Petrini EM, Barberis A, Wulff P, Wisden W, Sassoe-Pognetto Met al., 2013, Synaptic Competition Sculpts the Development of GABAergic Axo-Dendritic but Not Perisomatic Synapses, PLOS ONE, Vol: 8, ISSN: 1932-6203

Journal article

Zecharia AY, Yu X, Götz T, Ye Z, Carr DR, Wulff P, Bettler B, Vyssotski AL, Brickley SG, Franks NP, Wisden Wet al., 2012, GABAergic inhibition of histaminergic neurons regulates active waking but not the sleep-wake switch or propofol-induced loss of consciousness., J Neurosci, Vol: 32, Pages: 13062-13075

The activity of histaminergic neurons in the tuberomammillary nucleus (TMN) of the hypothalamus correlates with an animal's behavioral state and maintains arousal. We examined how GABAergic inputs onto histaminergic neurons regulate this behavior. A prominent hypothesis, the "flip-flop" model, predicts that increased and sustained GABAergic drive onto these cells promotes sleep. Similarly, because of the histaminergic neurons' key hub-like place in the arousal circuitry, it has also been suggested that anesthetics such as propofol induce loss of consciousness by acting primarily at histaminergic neurons. We tested both these hypotheses in mice by genetically removing ionotropic GABA(A) or metabotropic GABA(B) receptors from histidine decarboxylase-expressing neurons. At the cellular level, histaminergic neurons deficient in synaptic GABA(A) receptors were significantly more excitable and were insensitive to the anesthetic propofol. At the behavioral level, EEG profiles were recorded in nontethered mice over 24 h. Surprisingly, GABAergic transmission onto histaminergic neurons had no effect in regulating the natural sleep-wake cycle and, in the case of GABA(A) receptors, for propofol-induced loss of righting reflex. The latter finding makes it unlikely that the histaminergic TMN has a central role in anesthesia. GABA(B) receptors on histaminergic neurons were dispensable for all behaviors examined. Synaptic inhibition of histaminergic cells by GABA(A) receptors, however, was essential for habituation to a novel environment.

Journal article

Franks N, Brickley S, Wisden W, 2012, The relationship between natural sleep and general anaesthesia, 21st Congress of the European-Sleep-Research-Society, Publisher: WILEY-BLACKWELL, Pages: 47-47, ISSN: 0962-1105

Conference paper

Seja P, Schonewille M, Spitzmaul G, Badura A, Klein I, Rudhard Y, Wisden W, Huebner CA, De Zeeuw CI, Jentsch TJet al., 2012, Raising cytosolic Cl- in cerebellar granule cells affects their excitability and vestibulo-ocular learning, EMBO JOURNAL, Vol: 31, Pages: 1217-1230, ISSN: 0261-4189

Journal article

Leppa E, Linden A-M, Vekovischeva OY, Swinny JD, Rantanen V, Toppila E, Hoeger H, Sieghart W, Wulff P, Wisden W, Korpi ERet al., 2011, Removal of GABA(A) Receptor gamma 2 Subunits from Parvalbumin Neurons Causes Wide-Ranging Behavioral Alterations, PLOS ONE, Vol: 6, ISSN: 1932-6203

Journal article

Leppa E, Linden A-M, Rabe H, Vekovischeva OY, Wulff P, Lueddens H, Wisden W, Korpi ERet al., 2011, Actions of two GABA(A) receptor benzodiazepine-site ligands that are mediated via non-gamma 2-dependent modulation, EUROPEAN JOURNAL OF PHARMACOLOGY, Vol: 666, Pages: 111-121, ISSN: 0014-2999

Journal article

Murray AJ, Sauer J-F, Riedel G, McClure C, Ansel L, Cheyne L, Bartos M, Wisden W, Wulff Pet al., 2011, Parvalbumin-positive CA1 interneurons are required for spatial working but not for reference memory, NATURE NEUROSCIENCE, Vol: 14, Pages: 297-299, ISSN: 1097-6256

Journal article

Linden A-M, Schmitt U, Leppa E, Wulff P, Wisden W, Lueddens H, Korpi ERet al., 2011, Ro 15-4513 antagonizes alcohol-induced sedation in mice through alpha beta gamma 2-type GABA(A) receptors, FRONTIERS IN NEUROSCIENCE, Vol: 5, ISSN: 1662-453X

Journal article

Engelhardt T, Wisden W, 2011, Central nervous system: neurotransmitters and anesthesia, Pediatric Anesthesia: Basic principles - state of the art - future, Editors: Bissonnette, Anderson, Boesenberg, Engelhardt, Mason, Tobias, Shelton, Connecticut, USA, Publisher: People's Medical publishing House -USA, Pages: 71-79, ISBN: 978-1-60795-093-6

Book chapter

Muhammad S, Aller MI, Maser-Gluth C, Schwaninger M, Wisden Wet al., 2010, EXPRESSION OF THE KCNK3 POTASSIUM CHANNEL GENE LESSENS THE INJURY FROM CEREBRAL ISCHEMIA, MOST LIKELY BY A GENERAL INFLUENCE ON BLOOD PRESSURE, NEUROSCIENCE, Vol: 167, Pages: 758-764, ISSN: 0306-4522

Journal article

Heimann D, Bandulik S, Penton D, Lesage F, Wisden W, Barhanin J, Warth Ret al., 2010, The role of TASK potassium channels in the control of aldosterone secretion, ENDOCRINE JOURNAL, Vol: 57, Pages: S276-S276, ISSN: 0918-8959

Journal article

Wisden W, 2010, Cre-ating ways to serotonin, FRONTIERS IN NEUROSCIENCE, Vol: 4, ISSN: 1662-453X

Journal article

Wisden W, Meier JC, 2010, Genetic techniques and circuit analysis., Front Mol Neurosci, Vol: 3, ISSN: 1662-5099

Journal article

Pang DSJ, Robledo CJ, Carr DR, Gent TC, Vyssotski AL, Caley A, Zecharia AY, Wisden W, Brickley SG, Franks NPet al., 2009, An unexpected role for TASK-3 potassium channels in network oscillations with implications for sleep mechanisms and anesthetic action, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 106, Pages: 17546-17551, ISSN: 0027-8424

Journal article

Donner B, Schullenberg M, Huning A, Decking U, Kovacevic A, Wisden W, Schmidt KGet al., 2009, Cardiac phenotyping the TASK-1 deficient mouse, CLIN RES CARDIOL, Vol: 98, Pages: 589-589, ISSN: 1861-0684

Journal article

Wulff P, Schonewille M, Renzi M, Viltono L, Sassoe-Pognetto M, Badura A, Gao Z, Hoebeek FE, van Dorp S, Wisden W, Farrant M, De Zeeuw CIet al., 2009, Synaptic inhibition of Purkinje cells mediates consolidation of vestibulo-cerebellar motor learning, NATURE NEUROSCIENCE, Vol: 12, Pages: 1042-U118, ISSN: 1097-6256

Journal article

Wulff P, Ponomarenko AA, Bartos M, Korotkova TM, Fuchs EC, Baehner F, Both M, Tort ABL, Kopell NJ, Wisden W, Monyer Het al., 2009, Hippocampal theta rhythm and its coupling with gamma oscillations require fast inhibition onto parvalbumin-positive interneurons, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 106, Pages: 3561-3566, ISSN: 0027-8424

Journal article

Murray A, Black C, Cheyne L, Riedel G, Wisden W, Wulff Pet al., 2009, Selective modulation of parvalbumin GABAergic interneuron function in-vivo in mice, European-College-of-Neuropsychopharmacology Workshop on Neuropsychopharmacology for Young Scientists in Europe, Publisher: ELSEVIER SCIENCE BV, Pages: S20-S21, ISSN: 0924-977X

Conference paper

Murray A, Black C, Cheyne L, Riedel G, Wisden W, Wulff Pet al., 2009, P.1.22 Selective modulation of parvalbumin GABAergic interneuron function in-vivo in mice, European Neuropsychopharmacology, Vol: 19, Pages: S20-S21, ISSN: 0924-977X

Journal article

Wisden W, 2009, S.1.02 Engineering receptor subtypes as tools in neuropsychopharmacology, European Neuropsychopharmacology, Vol: 19, Pages: S2-S3, ISSN: 0924-977X

Journal article

Wisden W, 2009, Engineering receptor subtypes as tools in neuropsychopharmacology, European-College-of-Neuropsychopharmacology Workshop on Neuropsychopharmacology for Young Scientists in Europe, Publisher: ELSEVIER SCIENCE BV, Pages: S2-S3, ISSN: 0924-977X

Conference paper

Gajendran N, Kapfhammer JP, Lain E, Canepari M, Vogt K, Wisden W, Brenner HRet al., 2009, Neuregulin Signaling Is Dispensable for NMDA- and GABA(A)-Receptor Expression in the Cerebellum In Vivo, JOURNAL OF NEUROSCIENCE, Vol: 29, Pages: 2404-2413, ISSN: 0270-6474

Journal article

Goetz T, Wulff P, Wisden W, 2009, GABA<inf>A</inf> Receptors: Molecular Biology, Cell Biology, and Pharmacology, Pages: 463-470

Γ-Aminobutyric acid A (GABAA) receptors are the principal means of delivering fast (millisecond) inhibition to neurons in the vertebrate central nervous system. The receptors are ligand-gated chloride channels in the nicotinic acetylcholine receptor superfamily. On the binding of two GABA molecules, a conformational change occurs, and Cl? moves into the cell, producing an inhibitory hyperpolarization. Drugs acting at the GABAA receptor are used widely in medicine, such as for the induction and maintenance of general anesthesia or to treat anxiety disorders, states of agitation, epilepsy, or sleep disorders. There is scope to develop these drugs further so that they produce fewer side effects. © 2009 Elsevier Ltd All rights reserved.

Journal article

Wisden W, Murray AJ, McClure C, Wulff Pet al., 2009, Studying cerebellar circuits by remote control of selected neuronal types with GABA(A) receptors, FRONTIERS IN MOLECULAR NEUROSCIENCE, Vol: 2, ISSN: 1662-5099

Journal article

Linden A-M, Aller MI, Leppa E, Rosenberg PH, Wisden W, Korpi ERet al., 2008, K+ channel TASK-1 knockout mice show enhanced sensitivities to ataxic and hypnotic effects of GABA(A) receptor ligands, JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, Vol: 327, Pages: 277-286, ISSN: 0022-3565

Journal article

Trapp S, Aller MI, Wisden W, Gourine AVet al., 2008, A role for TASK-1 (KCNK3) channels in the chemosensory control of breathing, JOURNAL OF NEUROSCIENCE, Vol: 28, Pages: 8844-8850, ISSN: 0270-6474

Journal article

Aller MI, Wisden W, 2008, Changes in expression of some two-pore domain potassium channel genes (KCNK) in selected brain regions of developing mice, NEUROSCIENCE, Vol: 151, Pages: 1154-1172, ISSN: 0306-4522

Journal article

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