194 results found
Wulff P, Goetz T, Leppa E, et al., 2007, From synapse to behavior: rapid modulation of defined neuronal types with engineered GABAA receptors, NATURE NEUROSCIENCE, Vol: 10, Pages: 923-929, ISSN: 1097-6256
Korpi ER, Debus F, Linden A-M, et al., 2007, Does ethanol act preferentially via selected brain GABA(A) receptor subtypes? the current evidence is ambiguous, ALCOHOL, Vol: 41, Pages: 163-176, ISSN: 0741-8329
Goetz T, Arslan A, Wisden W, et al., 2007, GABA(A) receptors: structure and function in the basal ganglia, GABA AND THE BASAL GANGLIA: FROM MOLECULES TO SYSTEMS, Vol: 160, Pages: 21-41, ISSN: 0079-6123
Summerfield A, Wisden W, 2007, Fig.1 Cerebros Warhol, Paisajes neuronales. Homenaje a Santiago Ramon y Cajal, Editors: DeFelipe, Markram, Wagensberg, Pages: 195-195, ISBN: 9788400085339
Osten P, Wisden W, Sprengel R, 2007, Molecular mechanisms of synaptic function in the hippocampus: neurotransmitter exocytosis, glutamatergic, GABAergic and cholinergic transmission., The hippocampus book, Editors: Andersen, Morris, Amaral, Bliss, O'Keefe, Publisher: Oxford University Press, USA, Pages: 243-295, ISBN: 9780195100273
The Hippocampus Book is destined to take a central place on every neuroscientist'sbookshelf.
Linden AM, Aller MI, Leppa E, et al., 2006, The in vivo contributions of TASK-1-containing channels to the actions of inhalation anesthetics, the alpha(2) adrenergic sedative dexmedetomidine, and cannabinoid agonists, JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, Vol: 317, Pages: 615-626, ISSN: 0022-3565
Meuth SG, Aller MI, Munsch T, et al., 2006, The contribution of TWIK-related acid-sensitive K+-containing channels to the function of dorsal lateral geniculate thalamocortical relay neurons, MOLECULAR PHARMACOLOGY, Vol: 69, Pages: 1468-1476, ISSN: 0026-895X
Aller MI, Veale EL, Linden AM, et al., 2005, Modifying the subunit composition of TASK channels alters the modulation of a leak conductance in cerebellar granule neurons, JOURNAL OF NEUROSCIENCE, Vol: 25, Pages: 11455-11467, ISSN: 0270-6474
Cope DW, Halbsguth C, Karayannis T, et al., 2005, Loss of zolpidem efficacy in the hippocampus of mice with the GABA(A) receptor gamma 2 F77I point mutation, EUROPEAN JOURNAL OF NEUROSCIENCE, Vol: 21, Pages: 3002-3016, ISSN: 0953-816X
Merlo D, Di Stasi AMM, Bonini P, et al., 2005, DNA repair in post-mitotic neurons: a gene-trapping strategy, CELL DEATH AND DIFFERENTIATION, Vol: 12, Pages: 307-309, ISSN: 1350-9047
Leppa E, Vekovischeva OY, Linden AM, et al., 2005, Agonistic effects of the beta-carboline DMCM revealed in GABA(A) receptor gamma 2 subunit F77I point-mutated mice, NEUROPHARMACOLOGY, Vol: 48, Pages: 469-478, ISSN: 0028-3908
Wulff P, Wisden W, 2005, Dissecting neural circuitry by combining genetics and pharmacology, TRENDS IN NEUROSCIENCES, Vol: 28, Pages: 44-50, ISSN: 0166-2236
Ogris W, Pöltl A, Hauer B, et al., 2004, Affinity of various benzodiazepine site ligands in mice with a point mutation in the GABA(A) receptor gamma2 subunit., Biochem Pharmacol, Vol: 68, Pages: 1621-1629, ISSN: 0006-2952
The benzodiazepine binding site of GABA(A) receptors is located at the interface of the alpha and gamma subunits. Certain point mutations in these subunits have been demonstrated to dramatically reduce the affinity of benzodiazepine binding site ligands for these receptors. Recently, mice were generated with a phenylalanine (F) to isoleucine (I) substitution at position 77 in the gamma2 subunit of GABA(A) receptors. Here we tested the potency of 24 benzodiazepine binding site ligands from 16 different structural classes for inhibition of [(3)H]flunitrazepam binding to brain membranes of these gamma2F77I mice. Results indicate that the potency of the classical 1,4-benzodiazepines, of the 1,4-thienodiazepine clotiazepam, the 1,5-benzodiazepine clobazam, or the pyrazoloquinoline CGS 9896 is only 2-7-fold reduced by this gamma2F77I point mutation. The potency of the imidazopyrimidines Ru 32698, Ru 33203, and Ru 33356, of the imidazoquinoline Ru 31719, or the pyrazolopyridine CGS 20625 is reduced 10-20-fold, whereas the potency of some imidazobenzodiazepines, beta-carbolines, cyclopyrrolones, imidazopyridines, triazolopyridazines, or quinolines is 100-1000-fold reduced. Interestingly, the extent of potency reduction induced by the gamma2F77I point mutation varied within the structural classes of compounds. Results support and significantly extend previous observations indicating that the residue gamma2F77 is important for high affinity binding of some, but not all benzodiazepine site ligands.
Ogris W, Poltl A, Hauer B, et al., 2004, Affinity of various benzodiazepine site ligands in mice with a point mutation in the GABA(A) receptor gamma 2 subunit, 6th Decades of GABA Conference, Publisher: PERGAMON-ELSEVIER SCIENCE LTD, Pages: 1621-1629, ISSN: 0006-2952
Sinkkonen ST, Vekovischeva OY, Moykkynen T, et al., 2004, Behavioural correlates of an altered balance between synaptic and extrasynaptic GABA(A)ergic inhibition in a mouse model, EUROPEAN JOURNAL OF NEUROSCIENCE, Vol: 20, Pages: 2168-2178, ISSN: 0953-816X
Cope DW, Wulff P, Oberto A, et al., 2004, Abolition of zolpidem sensitivity in mice with a point mutation in the GABA(A) receptor gamma 2 subunit, NEUROPHARMACOLOGY, Vol: 47, Pages: 17-34, ISSN: 0028-3908
Lauder AJ, Jolin HE, Smith P, et al., 2004, Lymphomagenesis, hydronephrosis, and autoantibodies result from dysregulation of IL-9 and are differentially dependent on Th2 cytokines, JOURNAL OF IMMUNOLOGY, Vol: 173, Pages: 113-122, ISSN: 0022-1767
Aller MI, Jones A, Merlo D, et al., 2003, Cerebellar granule cell Cre recombinase expression, GENESIS, Vol: 36, Pages: 97-103, ISSN: 1526-954X
Wisden W, Cope D, Klausberger T, et al., 2002, Ectopic expression of the GABA(A) receptor alpha 6 subunit in hippocampal pyramidal neurons produces extrasynaptic receptors and an increased tonic inhibition, NEUROPHARMACOLOGY, Vol: 43, Pages: 530-549, ISSN: 0028-3908
Wisden W, Morris BJ, 2002, In situ hybridization protocols for the brain -second edition, Publisher: Academic Pr, ISBN: 9780123668479
This volume of the International Review of Neurobiology was written to assist researchers without any previous experience with in situ hybridization, allowing ...
Wisden W, Morris BJ, 2002, In situ hybridization with oligonucleotide probes, IN SITU HYBRIDIZATION PROTOCOLS FOR THE BRAIN, 2ND EDITION, Vol: 47, Pages: 3-59, ISSN: 0074-7742
Wisden W, Morris BJ, 2002, Introduction: Studying gene expression in neural tissues by in situ hybridization, IN SITU HYBRIDIZATION PROTOCOLS FOR THE BRAIN, 2ND EDITION, Vol: 47, Pages: XVII-XXI, ISSN: 0074-7742
Wisden B, Morris B, 2002, Acknowledgements, International Review of Neurobiology, Vol: 47, ISSN: 0074-7742
Wisden W, Farrant M, 2002, Insights into GABA-A receptor complexity from the study of cerebellar granule cells: synaptic and extrasynaptic receptors., Glutamate and GABA receptors and transporters, Editors: Egebjerg, Krogsgaard-Larsen, Schousboe, Publisher: CRC, Pages: 189-201, ISBN: 9780748408818
This book conveys recent discoveries in a framework of the basic concepts in the fieldof glutamate and GABA receptor research.
Wisden W, Morris BJ, 2002, Introduction: studying gene expression in neural tissues by in situ hybridization., Int Rev Neurobiol, Vol: 47, Pages: xvii-xxi, ISSN: 0074-7742
Bedford FK, Kittler JT, Muller E, et al., 2001, GABA(A) receptor cell surface number and subunit stability are regulated by the ubiquitin-like protein Plic-1, NATURE NEUROSCIENCE, Vol: 4, Pages: 908-916, ISSN: 1097-6256
Brickley SG, Revilla V, Cull-Candy SG, et al., 2001, Adaptive regulation of neuronal excitability by a voltage-independent potassium conductance, NATURE, Vol: 409, Pages: 88-92, ISSN: 0028-0836
Campos ML, De Cabo C, Wisden W, et al., 2001, Expression of GABA(A) receptor subunits in rat brainstem auditory pathways: Cochlear nuclei, superior olivary complex and nucleus of the lateral lemniscus, NEUROSCIENCE, Vol: 102, Pages: 625-638, ISSN: 0306-4522
Wisden W, Seeburg PH, Monyer H, 2000, Chapter IV AMPA, kainate and NMDA ionotropic glutamate receptor expression-an in situ hybridization atlas, Handbook of Chemical Neuroanatomy, Vol: 18, Pages: 99-143, ISSN: 0924-8196
Most rat neocortical neurons have Ca2+-impermeable AMPA receptors containing GluR-A/B, heteromeric receptors will be least numerous in layer IV cells (Fig. 11) (discussed by Conti et al., 1994a). Most GABAergic interneurons have Ca2+-permeable AMPA receptors made from GluR-A/D subunits; these receptors will have fast kinetics and high single-channel conductance. © 2000 Elsevier B.V. All rights reserved.
Wisden W, Seeburg PH, Monyer H, 2000, AMPA, kainate and NMDA ionotropic glutamate receptor expression: an in situ hybridization atlas., Glutamate, Editors: Ottersen, Storm-Mathisen, Publisher: Elsevier Science Ltd, Pages: 99-143, ISBN: 9780444502865
The volume presents a comprehensive and up-to-date treatise of the glutamatergic synapse and its environment.
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