Imperial College London

Prof. William Wisden F. Med. Sci.

Faculty of Natural SciencesDepartment of Life Sciences

Chair in Molecular Neuroscience
 
 
 
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Contact

 

+44 (0)20 7594 9744w.wisden Website CV

 
 
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Location

 

401BSir Ernst Chain BuildingSouth Kensington Campus

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Summary

 

Publications

Publication Type
Year
to

192 results found

Korpi ER, Debus F, Linden A-M, Malecot C, Leppa E, Vekovischeva O, Rabe H, Boehme I, Aller MI, Wisden W, Lueddens Het al., 2007, Does ethanol act preferentially via selected brain GABA(A) receptor subtypes? the current evidence is ambiguous, ALCOHOL, Vol: 41, Pages: 163-176, ISSN: 0741-8329

Journal article

Goetz T, Arslan A, Wisden W, Wulff Pet al., 2007, GABA(A) receptors: structure and function in the basal ganglia, GABA AND THE BASAL GANGLIA: FROM MOLECULES TO SYSTEMS, Vol: 160, Pages: 21-41, ISSN: 0079-6123

Journal article

Summerfield A, Wisden W, 2007, Fig.1 Cerebros Warhol, Paisajes neuronales. Homenaje a Santiago Ramon y Cajal, Editors: DeFelipe, Markram, Wagensberg, Pages: 195-195, ISBN: 9788400085339

Book chapter

Osten P, Wisden W, Sprengel R, 2007, Molecular mechanisms of synaptic function in the hippocampus: neurotransmitter exocytosis, glutamatergic, GABAergic and cholinergic transmission., The hippocampus book, Editors: Andersen, Morris, Amaral, Bliss, O'Keefe, Publisher: Oxford University Press, USA, Pages: 243-295, ISBN: 9780195100273

The Hippocampus Book is destined to take a central place on every neuroscientist'sbookshelf.

Book chapter

Linden AM, Aller MI, Leppa E, Vekovischeva O, Aitta-Aho T, Veale EL, Mathie A, Rosenberg P, Wisden W, Korpi ERet al., 2006, The in vivo contributions of TASK-1-containing channels to the actions of inhalation anesthetics, the alpha(2) adrenergic sedative dexmedetomidine, and cannabinoid agonists, JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, Vol: 317, Pages: 615-626, ISSN: 0022-3565

Journal article

Meuth SG, Aller MI, Munsch T, Schuhmacher T, Seidenbecher T, Meuth P, Kleinschnitz C, Pape HC, Wiendl H, Wisden W, Budde Tet al., 2006, The contribution of TWIK-related acid-sensitive K+-containing channels to the function of dorsal lateral geniculate thalamocortical relay neurons, MOLECULAR PHARMACOLOGY, Vol: 69, Pages: 1468-1476, ISSN: 0026-895X

Journal article

Aller MI, Veale EL, Linden AM, Sandu C, Schwaninger M, Evans LJ, Korpi ER, Mathie A, Wisden W, Brickley SGet al., 2005, Modifying the subunit composition of TASK channels alters the modulation of a leak conductance in cerebellar granule neurons, JOURNAL OF NEUROSCIENCE, Vol: 25, Pages: 11455-11467, ISSN: 0270-6474

Journal article

Cope DW, Halbsguth C, Karayannis T, Wulff P, Ferraguti F, Hoeger H, Leppa E, Linden AM, Oberto A, Ogris W, Korpi ER, Sieghart W, Somogyi P, Wisden W, Capogna Met al., 2005, Loss of zolpidem efficacy in the hippocampus of mice with the GABA(A) receptor gamma 2 F77I point mutation, EUROPEAN JOURNAL OF NEUROSCIENCE, Vol: 21, Pages: 3002-3016, ISSN: 0953-816X

Journal article

Merlo D, Di Stasi AMM, Bonini P, Mollinari C, Cardinale A, Cozzolino F, Wisden W, Garaci Eet al., 2005, DNA repair in post-mitotic neurons: a gene-trapping strategy, CELL DEATH AND DIFFERENTIATION, Vol: 12, Pages: 307-309, ISSN: 1350-9047

Journal article

Leppa E, Vekovischeva OY, Linden AM, Wulff P, Oberto A, Wisden W, Korpi ERet al., 2005, Agonistic effects of the beta-carboline DMCM revealed in GABA(A) receptor gamma 2 subunit F77I point-mutated mice, NEUROPHARMACOLOGY, Vol: 48, Pages: 469-478, ISSN: 0028-3908

Journal article

Wulff P, Wisden W, 2005, Dissecting neural circuitry by combining genetics and pharmacology, TRENDS IN NEUROSCIENCES, Vol: 28, Pages: 44-50, ISSN: 0166-2236

Journal article

Ogris W, Pöltl A, Hauer B, Ernst M, Oberto A, Wulff P, Höger H, Wisden W, Sieghart Wet al., 2004, Affinity of various benzodiazepine site ligands in mice with a point mutation in the GABA(A) receptor gamma2 subunit., Biochem Pharmacol, Vol: 68, Pages: 1621-1629, ISSN: 0006-2952

The benzodiazepine binding site of GABA(A) receptors is located at the interface of the alpha and gamma subunits. Certain point mutations in these subunits have been demonstrated to dramatically reduce the affinity of benzodiazepine binding site ligands for these receptors. Recently, mice were generated with a phenylalanine (F) to isoleucine (I) substitution at position 77 in the gamma2 subunit of GABA(A) receptors. Here we tested the potency of 24 benzodiazepine binding site ligands from 16 different structural classes for inhibition of [(3)H]flunitrazepam binding to brain membranes of these gamma2F77I mice. Results indicate that the potency of the classical 1,4-benzodiazepines, of the 1,4-thienodiazepine clotiazepam, the 1,5-benzodiazepine clobazam, or the pyrazoloquinoline CGS 9896 is only 2-7-fold reduced by this gamma2F77I point mutation. The potency of the imidazopyrimidines Ru 32698, Ru 33203, and Ru 33356, of the imidazoquinoline Ru 31719, or the pyrazolopyridine CGS 20625 is reduced 10-20-fold, whereas the potency of some imidazobenzodiazepines, beta-carbolines, cyclopyrrolones, imidazopyridines, triazolopyridazines, or quinolines is 100-1000-fold reduced. Interestingly, the extent of potency reduction induced by the gamma2F77I point mutation varied within the structural classes of compounds. Results support and significantly extend previous observations indicating that the residue gamma2F77 is important for high affinity binding of some, but not all benzodiazepine site ligands.

Journal article

Ogris W, Poltl A, Hauer B, Ernst M, Oberto A, Wulff P, Hoger H, Wisden W, Sieghart Wet al., 2004, Affinity of various benzodiazepine site ligands in mice with a point mutation in the GABA(A) receptor gamma 2 subunit, 6th Decades of GABA Conference, Publisher: PERGAMON-ELSEVIER SCIENCE LTD, Pages: 1621-1629, ISSN: 0006-2952

Conference paper

Sinkkonen ST, Vekovischeva OY, Moykkynen T, Ogris W, Sieghart W, Wisden W, Korpi ERet al., 2004, Behavioural correlates of an altered balance between synaptic and extrasynaptic GABA(A)ergic inhibition in a mouse model, EUROPEAN JOURNAL OF NEUROSCIENCE, Vol: 20, Pages: 2168-2178, ISSN: 0953-816X

Journal article

Cope DW, Wulff P, Oberto A, Aller MI, Capogna M, Ferraguti F, Halbsguth C, Hoeger H, Jolin HE, Jones A, Mckenzie ANJ, Ogris W, Poeltl A, Sinkkonen ST, Vekovischeva OY, Korpi ER, Sieghart W, Sigel E, Somogyi P, Wisden Wet al., 2004, Abolition of zolpidem sensitivity in mice with a point mutation in the GABA(A) receptor gamma 2 subunit, NEUROPHARMACOLOGY, Vol: 47, Pages: 17-34, ISSN: 0028-3908

Journal article

Lauder AJ, Jolin HE, Smith P, van den Berg JG, Jones A, Wisden W, Smith KGC, Dasvarma A, Fallon PG, McKenzie ANJet al., 2004, Lymphomagenesis, hydronephrosis, and autoantibodies result from dysregulation of IL-9 and are differentially dependent on Th2 cytokines, JOURNAL OF IMMUNOLOGY, Vol: 173, Pages: 113-122, ISSN: 0022-1767

Journal article

Aller MI, Jones A, Merlo D, Paterlini M, Meyer AH, Arntmann U, Brickley S, Jolin HE, McKenzie ANJ, Monyer H, Farrant M, Wisden Wet al., 2003, Cerebellar granule cell Cre recombinase expression, GENESIS, Vol: 36, Pages: 97-103, ISSN: 1526-954X

Journal article

Wisden W, Cope D, Klausberger T, Hauer B, Sinkkonen ST, Tretter V, Lujan R, Jones A, Korpi ER, Mody I, Sieghart W, Somogyi Pet al., 2002, Ectopic expression of the GABA(A) receptor alpha 6 subunit in hippocampal pyramidal neurons produces extrasynaptic receptors and an increased tonic inhibition, NEUROPHARMACOLOGY, Vol: 43, Pages: 530-549, ISSN: 0028-3908

Journal article

Wisden W, Morris BJ, 2002, In situ hybridization protocols for the brain -second edition, Publisher: Academic Pr, ISBN: 9780123668479

This volume of the International Review of Neurobiology was written to assist researchers without any previous experience with in situ hybridization, allowing ...

Book

Wisden W, Morris BJ, 2002, In situ hybridization with oligonucleotide probes, IN SITU HYBRIDIZATION PROTOCOLS FOR THE BRAIN, 2ND EDITION, Vol: 47, Pages: 3-59, ISSN: 0074-7742

Journal article

Wisden W, Morris BJ, 2002, Introduction: Studying gene expression in neural tissues by in situ hybridization, IN SITU HYBRIDIZATION PROTOCOLS FOR THE BRAIN, 2ND EDITION, Vol: 47, Pages: XVII-XXI, ISSN: 0074-7742

Journal article

Wisden B, Morris B, 2002, Acknowledgements, International Review of Neurobiology, Vol: 47, ISSN: 0074-7742

Journal article

Wisden W, Farrant M, 2002, Insights into GABA-A receptor complexity from the study of cerebellar granule cells: synaptic and extrasynaptic receptors., Glutamate and GABA receptors and transporters, Editors: Egebjerg, Krogsgaard-Larsen, Schousboe, Publisher: CRC, Pages: 189-201, ISBN: 9780748408818

This book conveys recent discoveries in a framework of the basic concepts in the fieldof glutamate and GABA receptor research.

Book chapter

Wisden W, Morris BJ, 2002, Introduction: studying gene expression in neural tissues by in situ hybridization., Int Rev Neurobiol, Vol: 47, Pages: xvii-xxi, ISSN: 0074-7742

Journal article

Bedford FK, Kittler JT, Muller E, Thomas P, Uren JM, Merlo D, Wisden W, Triller A, Smart TG, Moss SJet al., 2001, GABA(A) receptor cell surface number and subunit stability are regulated by the ubiquitin-like protein Plic-1, NATURE NEUROSCIENCE, Vol: 4, Pages: 908-916, ISSN: 1097-6256

Journal article

Brickley SG, Revilla V, Cull-Candy SG, Wisden W, Farrant Met al., 2001, Adaptive regulation of neuronal excitability by a voltage-independent potassium conductance, NATURE, Vol: 409, Pages: 88-92, ISSN: 0028-0836

Journal article

Campos ML, De Cabo C, Wisden W, Juiz JM, Merlo Det al., 2001, Expression of GABA(A) receptor subunits in rat brainstem auditory pathways: Cochlear nuclei, superior olivary complex and nucleus of the lateral lemniscus, NEUROSCIENCE, Vol: 102, Pages: 625-638, ISSN: 0306-4522

Journal article

Wisden W, Seeburg PH, Monyer H, 2000, Chapter IV AMPA, kainate and NMDA ionotropic glutamate receptor expression-an in situ hybridization atlas, Handbook of Chemical Neuroanatomy, Vol: 18, Pages: 99-143, ISSN: 0924-8196

Most rat neocortical neurons have Ca2+-impermeable AMPA receptors containing GluR-A/B, heteromeric receptors will be least numerous in layer IV cells (Fig. 11) (discussed by Conti et al., 1994a). Most GABAergic interneurons have Ca2+-permeable AMPA receptors made from GluR-A/D subunits; these receptors will have fast kinetics and high single-channel conductance. © 2000 Elsevier B.V. All rights reserved.

Journal article

Wisden W, Seeburg PH, Monyer H, 2000, AMPA, kainate and NMDA ionotropic glutamate receptor expression: an in situ hybridization atlas., Glutamate, Editors: Ottersen, Storm-Mathisen, Publisher: Elsevier Science Ltd, Pages: 99-143, ISBN: 9780444502865

The volume presents a comprehensive and up-to-date treatise of the glutamatergic synapse and its environment.

Book chapter

Wisden W, 2000, Technical workshop: Ligand-gated ion channel diversity, Publisher: BLACKWELL SCIENCE LTD, Pages: 382-382, ISSN: 0953-816X

Conference paper

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