Imperial College London

Prof. William Wisden F. Med. Sci.

Faculty of Natural SciencesDepartment of Life Sciences

Chair in Molecular Neuroscience



+44 (0)20 7594 9744w.wisden Website CV




401BSir Ernst Chain BuildingSouth Kensington Campus






BibTex format

author = {Makela, R and Wisden, W and Korpi, ER},
journal = {Eur J Pharmacol},
pages = {101--105},
title = {Loreclezole and La3+ differentiate cerebellar granule cell GABA(A) receptor subtypes},
url = {},
volume = {367},
year = {1999}

RIS format (EndNote, RefMan)

AB - The effects of loreclezole and La3+ on native cerebellar GABA(A) receptors were compared between GABA(A) receptor alpha6 subunit-deficient (alpha6-/-) and wildtype mouse lines, produced through homologous recombination, using t-[35S]butylbicyclophosphorothionate ([35S]TBPS) autoradiography in brain sections. In the alpha6 subunit-deficient mice, the GABA receptor antagonistic ability of La3+ was abolished in the cerebellar granule cell layer, consistent with its opposite actions on alpha6- and of alpha1 subunit-containing receptors. La3+ significantly potentiated the action of GABA in the molecular layer of the alpha6-/- mice, but not in that of the wildtype mice. The potentiation of agonistic GABA inhibition of [35S]TBPS binding by loreclezole in alpha6-/- granule cells was reduced, suggesting an emergence of low-affinity GABA(A) receptors. The present results thus identified two ligands that may be useful in studying functional roles of cerebellar alpha1 and alpha6 subunit-containing GABA(A) receptor subtypes.
AU - Makela,R
AU - Wisden,W
AU - Korpi,ER
EP - 105
PY - 1999///
SN - 0014-2999
SP - 101
TI - Loreclezole and La3+ differentiate cerebellar granule cell GABA(A) receptor subtypes
T2 - Eur J Pharmacol
UR -
VL - 367
ER -