Imperial College London

Prof. William Wisden F. Med. Sci.

Faculty of Natural SciencesDepartment of Life Sciences

Chair in Molecular Neuroscience



+44 (0)20 7594 9744w.wisden Website CV




401BSir Ernst Chain BuildingSouth Kensington Campus






BibTex format

author = {Wisden, W and Yu, X and Zecharia, A and Zhang, Z and Yang, Q and Yustos, R and Jager, P and Vyssotski, AL and Maywood, ES and Chesham, JE and Ma, Y and Brickley, SG and Hastings, MH and Franks, NP},
doi = {10.1016/j.cub.2014.10.019},
journal = {Current Biology},
pages = {1--7},
title = {Circadian Factor BMAL1 in Histaminergic Neurons Regulates Sleep Architecture},
url = {},
volume = {24},
year = {2014}

RIS format (EndNote, RefMan)

AB - Circadian clocks allow anticipation of daily environmental changes [ 1 ]. The suprachiasmatic nucleus (SCN) houses the master clock, but clocks are also widely expressed elsewhere in the body [ 1 ]. Although some peripheral clocks have established roles [ 1 ], it is unclear what local brain clocks do [ 2, 3 ]. We tested the contribution of one putative local clock in mouse histaminergic neurons in the tuberomamillary nucleus to the regulation of the sleep-wake cycle. Histaminergic neurons are silent during sleep, and start firing after wake onset [ 4–6 ]; the released histamine, made by the enzyme histidine decarboxylase (HDC), enhances wakefulness [ 7–11 ]. We found that hdc gene expression varies with time of day. Selectively deleting the Bmal1 (also known as Arntl or Mop3 [ 12 ]) clock gene from histaminergic cells removes this variation, producing higher HDC expression and brain histamine levels during the day. The consequences include more fragmented sleep, prolonged wake at night, shallower sleep depth (lower nonrapid eye movement [NREM] δ power), increased NREM-to-REM transitions, hindered recovery sleep after sleep deprivation, and impaired memory. Removing BMAL1 from histaminergic neurons does not, however, affect circadian rhythms. We propose that for mammals with polyphasic/nonwake consolidating sleep, the local BMAL1-dependent clock directs appropriately timed declines and increases in histamine biosynthesis to produce an appropriate balance of wake and sleep within the overall daily cycle of rest and activity specified by the SCN.
AU - Wisden,W
AU - Yu,X
AU - Zecharia,A
AU - Zhang,Z
AU - Yang,Q
AU - Yustos,R
AU - Jager,P
AU - Vyssotski,AL
AU - Maywood,ES
AU - Chesham,JE
AU - Ma,Y
AU - Brickley,SG
AU - Hastings,MH
AU - Franks,NP
DO - 10.1016/j.cub.2014.10.019
EP - 7
PY - 2014///
SN - 1879-0445
SP - 1
TI - Circadian Factor BMAL1 in Histaminergic Neurons Regulates Sleep Architecture
T2 - Current Biology
UR -
UR -
UR -
VL - 24
ER -