Imperial College London

Prof. William Wisden F. Med. Sci.

Faculty of Natural SciencesDepartment of Life Sciences

Chair in Molecular Neuroscience
 
 
 
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Contact

 

+44 (0)20 7594 9744w.wisden Website CV

 
 
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Location

 

401BSir Ernst Chain BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Jager:2016:10.1038/ncomms13579,
author = {Jager, P and Ye, Z and Yu, X and Zagoraiou, L and Prekop, H-T and Partanen, J and Jessell, TM and Wisden, W and Brickley, SG and Delogu, A},
doi = {10.1038/ncomms13579},
journal = {Nature Communications},
title = {Tectal-derived interneurons contribute to phasic and tonic inhibition in the visual thalamus},
url = {http://dx.doi.org/10.1038/ncomms13579},
volume = {7},
year = {2016}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - The release of GABA from local interneurons in the dorsal lateral geniculate nucleus (dLGN-INs) provides inhibitory control during visual processing within the thalamus. It is commonly assumed that this important class of interneurons originates from within the thalamic complex, but we now show that during early postnatal development Sox14/Otx2-expressing precursor cells migrate from the dorsal midbrain to generate dLGN-INs. The unexpected extra-diencephalic origin of dLGN-INs sets them apart from GABAergic neurons of the reticular thalamic nucleus. Using optogenetics we show that at increased firing rates tectal-derived dLGN-INs generate a powerful form of tonic inhibition that regulates the gain of thalamic relay neurons through recruitment of extrasynaptic high-affinity GABAA receptors. Therefore, by revising the conventional view of thalamic interneuron ontogeny we demonstrate how a previously unappreciated mesencephalic population controls thalamic relay neuron excitability.
AU - Jager,P
AU - Ye,Z
AU - Yu,X
AU - Zagoraiou,L
AU - Prekop,H-T
AU - Partanen,J
AU - Jessell,TM
AU - Wisden,W
AU - Brickley,SG
AU - Delogu,A
DO - 10.1038/ncomms13579
PY - 2016///
SN - 2041-1723
TI - Tectal-derived interneurons contribute to phasic and tonic inhibition in the visual thalamus
T2 - Nature Communications
UR - http://dx.doi.org/10.1038/ncomms13579
UR - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000389492900001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR - http://hdl.handle.net/10044/1/44921
VL - 7
ER -