Publications
219 results found
Goetz T, Arslan A, Wisden W, et al., 2007, GABA<sub>A</sub> receptors:: structure and function in the basal ganglia, GABA AND THE BASAL GANGLIA: FROM MOLECULES TO SYSTEMS, Vol: 160, Pages: 21-41, ISSN: 0079-6123
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- Citations: 83
Linden AM, Aller MI, Leppä E, et al., 2006, The in vivo contributions of TASK-1-containing channels to the actions of inhalation anesthetics, the α<sub>2</sub> adrenergic sedative dexmedetomidine, and cannabinoid agonists, JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, Vol: 317, Pages: 615-626, ISSN: 0022-3565
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- Citations: 69
Meuth SG, Aller MI, Munsch T, et al., 2006, The contribution of TWIK-related acid-sensitive K<SUP>+</SUP>-containing channels to the function of dorsal lateral geniculate thalamocortical relay neurons, MOLECULAR PHARMACOLOGY, Vol: 69, Pages: 1468-1476, ISSN: 0026-895X
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- Citations: 55
Aller MI, Veale EL, Linden AM, et al., 2005, Modifying the subunit composition of TASK channels alters the modulation of a leak conductance in cerebellar granule neurons, JOURNAL OF NEUROSCIENCE, Vol: 25, Pages: 11455-11467, ISSN: 0270-6474
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- Citations: 116
Cope DW, Halbsguth C, Karayannis T, et al., 2005, Loss of zolpidem efficacy in the hippocampus of mice with the GABA<sub>A</sub> receptor γ2 F77I point mutation, EUROPEAN JOURNAL OF NEUROSCIENCE, Vol: 21, Pages: 3002-3016, ISSN: 0953-816X
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- Citations: 30
Merlo D, Di Stasi AMM, Bonini P, et al., 2005, DNA repair in post-mitotic neurons: a gene-trapping strategy, CELL DEATH AND DIFFERENTIATION, Vol: 12, Pages: 307-309, ISSN: 1350-9047
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- Citations: 20
Leppä E, Vekovischeva OY, Lindén AM, et al., 2005, Agonistic effects of the β-carboline DMCM revealed in GABA<sub>A</sub> receptor γ2 subunit F77I point-mutated mice, NEUROPHARMACOLOGY, Vol: 48, Pages: 469-478, ISSN: 0028-3908
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- Citations: 20
Wulff P, Wisden W, 2005, Dissecting neural circuitry by combining genetics and pharmacology, TRENDS IN NEUROSCIENCES, Vol: 28, Pages: 44-50, ISSN: 0166-2236
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- Citations: 22
Ogris W, Pöltl A, Hauer B, et al., 2004, Affinity of various benzodiazepine site ligands in mice with a point mutation in the GABA(A) receptor gamma2 subunit., Biochem Pharmacol, Vol: 68, Pages: 1621-1629, ISSN: 0006-2952
The benzodiazepine binding site of GABA(A) receptors is located at the interface of the alpha and gamma subunits. Certain point mutations in these subunits have been demonstrated to dramatically reduce the affinity of benzodiazepine binding site ligands for these receptors. Recently, mice were generated with a phenylalanine (F) to isoleucine (I) substitution at position 77 in the gamma2 subunit of GABA(A) receptors. Here we tested the potency of 24 benzodiazepine binding site ligands from 16 different structural classes for inhibition of [(3)H]flunitrazepam binding to brain membranes of these gamma2F77I mice. Results indicate that the potency of the classical 1,4-benzodiazepines, of the 1,4-thienodiazepine clotiazepam, the 1,5-benzodiazepine clobazam, or the pyrazoloquinoline CGS 9896 is only 2-7-fold reduced by this gamma2F77I point mutation. The potency of the imidazopyrimidines Ru 32698, Ru 33203, and Ru 33356, of the imidazoquinoline Ru 31719, or the pyrazolopyridine CGS 20625 is reduced 10-20-fold, whereas the potency of some imidazobenzodiazepines, beta-carbolines, cyclopyrrolones, imidazopyridines, triazolopyridazines, or quinolines is 100-1000-fold reduced. Interestingly, the extent of potency reduction induced by the gamma2F77I point mutation varied within the structural classes of compounds. Results support and significantly extend previous observations indicating that the residue gamma2F77 is important for high affinity binding of some, but not all benzodiazepine site ligands.
Ogris W, Pöltl A, Hauer B, et al., 2004, Affinity of various benzodiazepine site ligands in mice with a point mutation in the GABA<sub>A</sub> receptor γ2 subunit, 6th Decades of GABA Conference, Publisher: PERGAMON-ELSEVIER SCIENCE LTD, Pages: 1621-1629, ISSN: 0006-2952
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- Citations: 38
Sinkkonen ST, Vekovischeva OY, Möykkynen T, et al., 2004, Behavioural correlates of an altered balance between synaptic and extrasynaptic GABA<sub>A</sub>ergic inhibition in a mouse model, EUROPEAN JOURNAL OF NEUROSCIENCE, Vol: 20, Pages: 2168-2178, ISSN: 0953-816X
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- Citations: 21
Lauder AJ, Jolin HE, Smith P, et al., 2004, Lymphomagenesis, hydronephrosis, and autoantibodies result from dysregulation of IL-9 and are differentially dependent on Th2 cytokines, JOURNAL OF IMMUNOLOGY, Vol: 173, Pages: 113-122, ISSN: 0022-1767
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- Citations: 13
Cope DW, Wulff P, Oberto A, et al., 2004, Abolition of zolpidem sensitivity in mice with a point mutation in the GABA<sub>A</sub> receptor γ2 subunit, NEUROPHARMACOLOGY, Vol: 47, Pages: 17-34, ISSN: 0028-3908
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- Citations: 60
Aller MI, Jones A, Merlo D, et al., 2003, Cerebellar granule cell Cre recombinase expression, GENESIS, Vol: 36, Pages: 97-103, ISSN: 1526-954X
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- Citations: 38
Wisden W, Cope D, Klausberger T, et al., 2002, Ectopic expression of the GABA<sub>A</sub> receptor α6 subunit in hippocampal pyramidal neurons produces extrasynaptic receptors and an increased tonic inhibition, NEUROPHARMACOLOGY, Vol: 43, Pages: 530-549, ISSN: 0028-3908
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- Citations: 60
Wisden W, Morris BJ, 2002, In situ hybridization protocols for the brain -second edition, Publisher: Academic Pr, ISBN: 9780123668479
This volume of the International Review of Neurobiology was written to assist researchers without any previous experience with in situ hybridization, allowing ...
Wisden B, Morris B, 2002, Acknowledgements, International Review of Neurobiology, Vol: 47, ISSN: 0074-7742
Wisden W, Morris BJ, 2002, Introduction: studying gene expression in neural tissues by in situ hybridization., Int Rev Neurobiol, Vol: 47, Pages: xvii-xxi, ISSN: 0074-7742
Wisden W, Farrant M, 2002, Insights into GABA-A receptor complexity from the study of cerebellar granule cells: synaptic and extrasynaptic receptors., Glutamate and GABA receptors and transporters, Editors: Egebjerg, Krogsgaard-Larsen, Schousboe, Publisher: CRC, Pages: 189-201, ISBN: 9780748408818
This book conveys recent discoveries in a framework of the basic concepts in the fieldof glutamate and GABA receptor research.
Wisden W, Morris BJ, 2002, Introduction:: Studying gene expression in neural tissues by <i>in situ</i> hybridization, IN SITU HYBRIDIZATION PROTOCOLS FOR THE BRAIN, 2ND EDITION, Vol: 47, Pages: XVII-XXI, ISSN: 0074-7742
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- Citations: 1
Wisden W, Morris BJ, 2002, <i>In situ</i> hybridization with oligonucleotide probes, IN SITU HYBRIDIZATION PROTOCOLS FOR THE BRAIN, 2ND EDITION, Vol: 47, Pages: 3-59, ISSN: 0074-7742
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- Citations: 29
Bedford FK, Kittler JT, Muller E, et al., 2001, GABA<sub>A</sub> receptor cell surface number and subunit stability are regulated by the ubiquitin-like protein Plic-1, NATURE NEUROSCIENCE, Vol: 4, Pages: 908-916, ISSN: 1097-6256
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- Citations: 187
Brickley SG, Revilla V, Cull-Candy SG, et al., 2001, Adaptive regulation of neuronal excitability by a voltage-independent potassium conductance, NATURE, Vol: 409, Pages: 88-92, ISSN: 0028-0836
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- Citations: 454
Campos ML, De Cabo C, Wisden W, et al., 2001, Expression of GABA<sub>A</sub> receptor subunits in rat brainstem auditory pathways:: Cochlear nuclei, superior olivary complex and nucleus of the lateral lemniscus, NEUROSCIENCE, Vol: 102, Pages: 625-638, ISSN: 0306-4522
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- Citations: 42
Wisden W, Seeburg PH, Monyer H, 2000, Chapter IV AMPA, kainate and NMDA ionotropic glutamate receptor expression-an in situ hybridization atlas, Handbook of Chemical Neuroanatomy, Vol: 18, Pages: 99-143, ISSN: 0924-8196
Most rat neocortical neurons have Ca2+-impermeable AMPA receptors containing GluR-A/B, heteromeric receptors will be least numerous in layer IV cells (Fig. 11) (discussed by Conti et al., 1994a). Most GABAergic interneurons have Ca2+-permeable AMPA receptors made from GluR-A/D subunits; these receptors will have fast kinetics and high single-channel conductance. © 2000 Elsevier B.V. All rights reserved.
Wisden W, Seeburg PH, Monyer H, 2000, AMPA, kainate and NMDA ionotropic glutamate receptor expression: an in situ hybridization atlas., Glutamate, Editors: Ottersen, Storm-Mathisen, Publisher: Elsevier Science Ltd, Pages: 99-143, ISBN: 9780444502865
The volume presents a comprehensive and up-to-date treatise of the glutamatergic synapse and its environment.
Jones A, Paterlini M, Wisden W, et al., 2000, Transgenic methods for directing gene expression to specific neuronal types: cerebellar granule cells., Progress in Brain Resaerch: Cerebellar modules: molecules, morphology and function, Editors: Gerrits, Ruigrok, De Zeeuw, Pages: 69-80, ISBN: 9780444801043
Jones A, Paterlini M, Wisden W, et al., 2000, Transgenic methods for directing gene expression to specific neuronal types: cerebellar granule cells, 2nd Symposium on Cerebellar Modules, Publisher: ELSEVIER SCIENCE BV, Pages: 69-80, ISSN: 0079-6123
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- Citations: 5
Wisden W, 2000, Technical workshop: Ligand-gated ion channel diversity, Publisher: BLACKWELL SCIENCE LTD, Pages: 382-382, ISSN: 0953-816X
Paterlini M, Revilla V, Grant AL, et al., 2000, Expression of the neuronal calcium sensor protein family in the rat brain, Neuroscience, Vol: 99, Pages: 205-216, ISSN: 0306-4522
The neuronal calcium sensor proteins are members of the calcium-binding protein superfamily. They control localized calcium signalling on membranes and may make G-protein cascades sensitive to cytosolic calcium. The family members are recoverin (visinin, S-modulin), neuronal calcium sensor-1 (frequenin), hippocalcin, neuronal visinin-like protein-1 (visinin-like protein, neurocalcin-alpha), neuronal visinin-like protein-2 and neuronal visinin-like protein-3. Recoverin is expressed only in the retina and pineal gland. Using in situ hybridization, we mapped the expression of the other neuronal calcium sensor protein genes in the adult rat brain. Neuronal visinin-like protein-1 messenger RNA has a widespread distribution and is abundant in all brain areas except the caudate-putamen. Neuronal calcium sensor-1 gene expression is pan-neuronal. Neuronal calcium sensor-1 messenger RNA is present in the dendrites of hippocampal pyramidal and granule cells, suggesting a specific role in dendritic function. Hippocalcin and neuronal visinin-like protein-2 are mainly expressed in the forebrain and have similar expression patterns (neocortex, hippocampus and caudate-putamen). Neuronal visinin-like protein-3 has the most restricted expression; its highest expression level is in the cerebellum (Purkinje and granule cells). However, the neuronal visinin-like protein-3 gene is also expressed in many ventral nuclei throughout the fore- and midbrain, in the medial habenulae, and in the superior and inferior colliculi. The neuronal calcium sensor proteins are a relatively unexplored family of Ca(2+)-binding proteins. They are likely to be involved in many diverse areas of neuronal signalling. In this paper, we describe their expression in the rat brain as determined by in situ hybridization. As all five neuronal calcium sensor protein genes have distinctive expression patterns, they probably perform specific functions.
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