Imperial College London
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Prof. William Wisden F. Med. Sci.

Faculty of Natural Sciences, Department of Life Sciences

Chair in Molecular Neuroscience
 
 
 
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Contact

 

+44 (0)20 7594 9744w.wisden Website CV

 
 
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Location

 

401BSir Ernst Chain BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Yu:2019:10.1038/s41593-018-0288-9,
author = {Yu, X and Li, W and Ma, Y and Tossell, K and Harris, J and Harding, E and Ba, W and Miracca, G and Wang, D and Li, L and Guo, J and Chen, M and Li, Y and Yustos, R and Vyssotski, A and Burdakov, D and Yang, Q and Dong, H and Franks, N and Wisden, W},
doi = {10.1038/s41593-018-0288-9},
journal = {Nature Neuroscience},
pages = {106--119},
title = {GABA and glutamate neurons in the VTA regulate sleep and wakefulness},
url = {http://dx.doi.org/10.1038/s41593-018-0288-9},
volume = {22},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - We screened for novel circuits in the mouse brain that promote wakefulness. Chemogenetic activation experiments and electroencephalogram recordings pointed to glutamatergic/nitrergic (NOS1) and GABAergic neurons in the ventral tegmental area (VTA). Activating glutamatergic/NOS1 neurons, which were wake- and rapid eye movement (REM) sleep-active, produced wakefulness through projections to the nucleus accumbens and the lateral hypothalamus. Lesioning the glutamate cells impaired the consolidation of wakefulness. By contrast, activation of GABAergic VTA neurons elicited long-lasting non-rapid-eye-movement-like sleep resembling sedation. Lesioning these neurons produced an increase in wakefulness that persisted for at least 4 months. Surprisingly, these VTA GABAergic neurons were wake- and REM sleep-active. We suggest that GABAergic VTA neurons may limit wakefulness by inhibiting the arousal-promoting VTA glutamatergic and/or dopaminergic neurons and through projections to the lateral hypothalamus. Thus, in addition to its contribution to goal- and reward-directed behaviors, the VTA has a role in regulating sleep and wakefulness.
AU  - Yu,X
AU  - Li,W
AU  - Ma,Y
AU  - Tossell,K
AU  - Harris,J
AU  - Harding,E
AU  - Ba,W
AU  - Miracca,G
AU  - Wang,D
AU  - Li,L
AU  - Guo,J
AU  - Chen,M
AU  - Li,Y
AU  - Yustos,R
AU  - Vyssotski,A
AU  - Burdakov,D
AU  - Yang,Q
AU  - Dong,H
AU  - Franks,N
AU  - Wisden,W
DO  - 10.1038/s41593-018-0288-9
EP  - 119
PY  - 2019///
SN  - 1097-6256
SP  - 106
TI  - GABA and glutamate neurons in the VTA regulate sleep and wakefulness
T2  - Nature Neuroscience
UR  - http://dx.doi.org/10.1038/s41593-018-0288-9
UR  - https://www.nature.com/articles/s41593-018-0288-9
UR  - http://hdl.handle.net/10044/1/65390
VL  - 22
ER  -
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