Imperial College London
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Prof. William Wisden F. Med. Sci.

Faculty of Natural Sciences, Department of Life Sciences

Chair in Molecular Neuroscience
 
 
 
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Contact

 

+44 (0)20 7594 9744w.wisden Website CV

 
 
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Location

 

401BSir Ernst Chain BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Ma:2019:10.1016/j.cub.2019.07.087,
author = {Ma, Y and Miracca, G and Yu, X and Harding, EC and Miao, A and Yustos, R and Vyssotski, AL and Franks, NP and Wisden, W},
doi = {10.1016/j.cub.2019.07.087},
journal = {Current biology : CB},
pages = {3315--3322.e3},
title = {Galanin Neurons Unite Sleep Homeostasis and α2-Adrenergic Sedation.},
url = {http://dx.doi.org/10.1016/j.cub.2019.07.087},
volume = {29},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Our urge to sleep increases with time spent awake, until sleep becomes inescapable. The sleep following sleep deprivation is longer and deeper, with an increased power of delta (0.5-4 Hz) oscillations, a phenomenon termed sleep homeostasis [1-4]. Although widely expressed genes regulate sleep homeostasis [1, 4-10] and the process is tracked by somnogens and phosphorylation [1, 3, 7, 11-14], at the circuit level sleep homeostasis has remained mysterious. Previously, we found that sedation induced with α2-adrenergic agonists (e.g., dexmedetomidine) and sleep homeostasis both depend on the preoptic (PO) hypothalamus [15, 16]. Dexmedetomidine, increasingly used for long-term sedation in intensive care units [17], induces a non-rapid-eye-movement (NREM)-like sleep but with undesirable hypothermia [18, 19]. Within the PO, various neuronal subtypes (e.g., GABA/galanin and glutamate/NOS1) induce NREM sleep [20-22] and concomitant body cooling [21, 22]. This could be because NREM sleep's restorative effects depend on lower body temperature [23, 24]. Here, we show that mice with lesioned PO galanin neurons have reduced sleep homeostasis: in the recovery sleep following sleep deprivation there is a diminished increase in delta power, and the mice catch up little on lost sleep. Furthermore, dexmedetomidine cannot induce high-power delta oscillations or sustained hypothermia. Some hours after dexmedetomidine administration to wild-type mice there is a rebound in delta power when they enter normal NREM sleep, reminiscent of emergence from torpor. This delta rebound is reduced in mice lacking PO galanin neurons. Thus, sleep homeostasis and dexmedetomidine-induced sedation require PO galanin neurons and likely share common mechanisms.
AU  - Ma,Y
AU  - Miracca,G
AU  - Yu,X
AU  - Harding,EC
AU  - Miao,A
AU  - Yustos,R
AU  - Vyssotski,AL
AU  - Franks,NP
AU  - Wisden,W
DO  - 10.1016/j.cub.2019.07.087
EP  - 3322
PY  - 2019///
SN  - 0960-9822
SP  - 3315
TI  - Galanin Neurons Unite Sleep Homeostasis and α2-Adrenergic Sedation.
T2  - Current biology : CB
UR  - http://dx.doi.org/10.1016/j.cub.2019.07.087
UR  - http://hdl.handle.net/10044/1/72568
VL  - 29
ER  -
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