Imperial College London
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Prof. William Wisden F. Med. Sci.

Faculty of Natural Sciences, Department of Life Sciences

Chair in Molecular Neuroscience
 
 
 
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Contact

 

+44 (0)20 7594 9744w.wisden Website CV

 
 
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Location

 

401BSir Ernst Chain BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Nollet:2020:10.1098/rsfs.2019.0092,
author = {Nollet, M and Wisden, W and Franks, N},
doi = {10.1098/rsfs.2019.0092},
journal = {Interface Focus},
pages = {1--11},
title = {Sleep deprivation and stress - a reciprocal relationship},
url = {http://dx.doi.org/10.1098/rsfs.2019.0092},
volume = {10},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Sleep is highly conserved across evolution, suggesting vital biological functions that are  yet  to  be  fully  understood.  Animals  and  humans  experiencing  partial  sleep restriction   usually   exhibit   detrimental   physiological   responses,   while   total   and prolonged  sleep  loss  could  lead  to  death.  The  perturbation  of  sleep  homeostasis  is usually  accompanied  by  an  increase  of  the  hypothalamic-pituitary-adrenal  (HPA) axis, leading to a rise of circulating level of stress hormones (e.g., cortisol in humans, corticosterone  in  rodents).  Such  hormones  follow  a  circadian  release  pattern  under undisturbed conditions and participate in the regulation of sleep. The investigation of the  consequences  of  sleep  deprivation,  from  molecular  changes  to  behavioural alterations, has been used to study the fundamental functions of sleep. However, the reciprocal relationship between sleep and the activity of the HPA axis is problematic when investigating sleep using traditional sleep-deprivation protocols that can induce stress  per  se.  This  is  especially  true  in  studies  using  rodents  in  which  sleep deprivation  is  achieved  by  exogenous,  and  potentially  stressful,  sensory-motor stimulations that can undoubtedly confuse their conclusions. While more research is needed to explore the mechanisms underlying sleep loss and health, avoiding stress as a confounding factor in sleep-deprivation studies is therefore crucial. This review examines the evidence of the intricate links between sleep and stress in the context of  experimental  sleep  deprivation,  and  proposes  a  more  sophisticated  research framework  for  sleep-deprivation  procedures  that  could  benefit  from  recent  progress in  biotechnological  tools  for  precise  neuromodulation,  such  as  chemogenetics  and optogenetics,  as  well  as  improved  automated  real-time  sleep  scoring  algorithms.
AU  - Nollet,M
AU  - Wisden,W
AU  - Franks,N
DO  - 10.1098/rsfs.2019.0092
EP  - 11
PY  - 2020///
SN  - 2042-8901
SP  - 1
TI  - Sleep deprivation and stress - a reciprocal relationship
T2  - Interface Focus
UR  - http://dx.doi.org/10.1098/rsfs.2019.0092
UR  - https://royalsocietypublishing.org/doi/10.1098/rsfs.2019.0092
UR  - http://hdl.handle.net/10044/1/77288
VL  - 10
ER  -
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