Imperial College London
Portrait Picture

Prof. William Wisden F. Med. Sci.

Faculty of Natural Sciences, Department of Life Sciences

Chair in Molecular Neuroscience
 
 
 
//

Contact

 

+44 (0)20 7594 9744w.wisden Website CV

 
 
//

Location

 

401BSir Ernst Chain BuildingSouth Kensington Campus

//

Summary

 

Publications

Citation

BibTex format

@unpublished{Tossell:2020:10.1101/2020.07.01.179671,
author = {Tossell, K and Yu, X and Soto, BA and Vicente, M and Miracca, G and Giannos, P and Miao, A and Hsieh, B and Ma, Y and Yustos, R and Vyssotski, A and Constandinou, T and Franks, N and Wisden, W},
doi = {10.1101/2020.07.01.179671},
publisher = {bioRxiv},
title = {Sleep deprivation triggers somatostatin neurons in prefrontal cortex to initiate nesting and sleep via the preoptic and lateral hypothalamus},
url = {http://dx.doi.org/10.1101/2020.07.01.179671},
year = {2020}
}
Download

RIS format (EndNote, RefMan)

TY  - UNPB
AB  - Animals undertake specific behaviors before sleep. Little is known about whether these innate behaviors, such as nest building, are actually an intrinsic part of the sleep-inducing circuitry. We found, using activity-tagging genetics, that mouse prefrontal cortex (PFC) somatostatin/GABAergic (SOM/GABA) neurons, which become activated during sleep deprivation, induce nest building when opto-activated. These tagged neurons induce sustained global NREM sleep if their activation is prolonged metabotropically. Sleep-deprivation-tagged PFC SOM/GABA neurons have long-range projections to the lateral preoptic (LPO) and lateral hypothalamus (LH). Local activation of tagged PFC SOM/GABA terminals in LPO and the LH induced nesting and NREM sleep respectively. Our findings provide a circuit link for how the PFC responds to sleep deprivation by coordinating sleep preparatory behavior and subsequent sleep.
AU  - Tossell,K
AU  - Yu,X
AU  - Soto,BA
AU  - Vicente,M
AU  - Miracca,G
AU  - Giannos,P
AU  - Miao,A
AU  - Hsieh,B
AU  - Ma,Y
AU  - Yustos,R
AU  - Vyssotski,A
AU  - Constandinou,T
AU  - Franks,N
AU  - Wisden,W
DO  - 10.1101/2020.07.01.179671
PB  - bioRxiv
PY  - 2020///
TI  - Sleep deprivation triggers somatostatin neurons in prefrontal cortex to initiate nesting and sleep via the preoptic and lateral hypothalamus
UR  - http://dx.doi.org/10.1101/2020.07.01.179671
UR  - http://hdl.handle.net/10044/1/90615
ER  -
Download