Imperial College London
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Prof. William Wisden F. Med. Sci.

Faculty of Natural Sciences, Department of Life Sciences

Chair in Molecular Neuroscience
 
 
 
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Contact

 

+44 (0)20 7594 9744w.wisden Website CV

 
 
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Location

 

401BSir Ernst Chain BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Yu:2022:10.1126/science.abn0853,
author = {Yu, X and Zhao, G and Wang, D and Wang, S and Li, R and Li, A and Wang, H and Nollet, M and Chun, YY and Zhao, T and Yustos, R and Li, H and Zhao, J and Li, J and Cai, M and Vyssotski, A and Li, Y and Dong, H and Franks, N and Wisden, W},
doi = {10.1126/science.abn0853},
journal = {Science},
pages = {1--10},
title = {A specific circuit in the midbrain detects stress and induces restorative sleep},
url = {http://dx.doi.org/10.1126/science.abn0853},
volume = {377},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - In mice, social defeat stress (SDS), an ethological model for psychosocial stress, induces sleep. Such sleep could enable resilience, but how stress promotes sleep is unclear. Activity - dependent tagging revealed a subset of ventral tegmental area GABA-somatostatin (VTAVgat-Sst) cells that sense stress and drive NREM and REM sleep via the lateral hypothalamus, andalso inhibit corticotropin-releasing factor (CRF) release in the paraventricular hypothalamus. Transient stress enhances the activity of VTA Vgat-Sst cells for several hours, allowing them to exert their sleep effects persistently. Lesioning of VTAVgat-Sst cells abolished SDS-induced sleep; without it, anxiety and corticosterone levels remained elevated after stress. Thus, aspecific circuit allows animals to restore mental and body functions via sleeping, potentially providing a refined route for treating anxiety disorders.
AU  - Yu,X
AU  - Zhao,G
AU  - Wang,D
AU  - Wang,S
AU  - Li,R
AU  - Li,A
AU  - Wang,H
AU  - Nollet,M
AU  - Chun,YY
AU  - Zhao,T
AU  - Yustos,R
AU  - Li,H
AU  - Zhao,J
AU  - Li,J
AU  - Cai,M
AU  - Vyssotski,A
AU  - Li,Y
AU  - Dong,H
AU  - Franks,N
AU  - Wisden,W
DO  - 10.1126/science.abn0853
EP  - 10
PY  - 2022///
SN  - 1095-9203
SP  - 1
TI  - A specific circuit in the midbrain detects stress and induces restorative sleep
T2  - Science
UR  - http://dx.doi.org/10.1126/science.abn0853
UR  - https://www.science.org/doi/10.1126/science.abn0853
UR  - http://hdl.handle.net/10044/1/97330
VL  - 377
ER  -
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