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@article{Imran:2021:10.3390/ijms22189900,
author = {Imran, SAM and Yazid, MD and Cui, W and Lokanathan, Y},
doi = {10.3390/ijms22189900},
journal = {International Journal of Molecular Sciences},
title = {The intra- and extra-telomeric role of TRF2 in the DNA damage response},
url = {http://dx.doi.org/10.3390/ijms22189900},
volume = {22},
year = {2021}
}

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TY  - JOUR
AB  - Telomere repeat binding factor 2 (TRF2) has a well-known function at the telomeres, which acts to protect the telomere end from being recognized as a DNA break or from unwanted recombination. This protection mechanism prevents DNA instability from mutation and subsequent severe diseases caused by the changes in DNA, such as cancer. Since TRF2 actively inhibits the DNA damage response factors from recognizing the telomere end as a DNA break, many more studies have also shown its interactions outside of the telomeres. However, very little has been discovered on the mechanisms involved in these interactions. This review aims to discuss the known function of TRF2 and its interaction with the DNA damage response (DDR) factors at both telomeric and non-telomeric regions. In this review, we will summarize recent progress and findings on the interactions between TRF2 and DDR factors at telomeres and outside of telomeres.
AU  - Imran,SAM
AU  - Yazid,MD
AU  - Cui,W
AU  - Lokanathan,Y
DO  - 10.3390/ijms22189900
PY  - 2021///
SN  - 1422-0067
TI  - The intra- and extra-telomeric role of TRF2 in the DNA damage response
T2  - International Journal of Molecular Sciences
UR  - http://dx.doi.org/10.3390/ijms22189900
UR  - https://www.ncbi.nlm.nih.gov/pubmed/34576063
UR  - http://hdl.handle.net/10044/1/96334
VL  - 22
ER  -

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