Imperial College London
Alternate

DrWeiCui

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 2124wei.cui Website

 
 
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Location

 

1010Institute of Reproductive and Developmental BiologyHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Zhang:2014:10.4252/wjsc.v6.i3.305,
author = {Zhang, S and Cui, W},
doi = {10.4252/wjsc.v6.i3.305},
journal = {World Journal of Stem Cells},
pages = {305--311},
title = {Sox2, a key factor in the regulation of pluripotency and neural differentiation.},
url = {http://dx.doi.org/10.4252/wjsc.v6.i3.305},
volume = {6},
year = {2014}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Sex determining region Y-box 2 (Sox2), a member of the SoxB1 transcription factor family, is an important transcriptional regulator in pluripotent stem cells (PSCs). Together with octamer-binding transcription factor 4 and Nanog, they co-operatively control gene expression in PSCs and maintain their pluripotency. Furthermore, Sox2 plays an essential role in somatic cell reprogramming, reversing the epigenetic configuration of differentiated cells back to a pluripotent embryonic state. In addition to its role in regulation of pluripotency, Sox2 is also a critical factor for directing the differentiation of PSCs to neural progenitors and for maintaining the properties of neural progenitor stem cells. Here, we review recent findings concerning the involvement of Sox2 in pluripotency, somatic cell reprogramming and neural differentiation as well as the molecular mechanisms underlying these roles.
AU  - Zhang,S
AU  - Cui,W
DO  - 10.4252/wjsc.v6.i3.305
EP  - 311
PY  - 2014///
SN  - 1948-0210
SP  - 305
TI  - Sox2, a key factor in the regulation of pluripotency and neural differentiation.
T2  - World Journal of Stem Cells
UR  - http://dx.doi.org/10.4252/wjsc.v6.i3.305
UR  - http://hdl.handle.net/10044/1/26889
VL  - 6
ER  -
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