Imperial College London
Alternate

DrWeiCui

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 2124wei.cui Website

 
 
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Location

 

1010Institute of Reproductive and Developmental BiologyHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Cui:2016:10.1242/dev.137075,
author = {Cui, W and Yu, J},
doi = {10.1242/dev.137075},
journal = {Development},
pages = {3050--3060},
title = {Proliferation, survival and metabolism: the role of PI3K/AKT/mTOR signalling in pluripotency and cell fate determination},
url = {http://dx.doi.org/10.1242/dev.137075},
volume = {143},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Phosphatidylinositide 3 kinases (PI3Ks) and their downstream mediators AKT and mammaliantarget of rapamycin (mTOR) constitute the core components of the PI3K/AKT/mTORsignalling cascade, regulating cell proliferation, survival and metabolism. Although thesefunctions are well defined in the context of tumorigenesis, recent studies – in particular thoseusing pluripotent stem cells – have highlighted the importance of this pathway to developmentand cellular differentiation. Here we review the recent in vitro and in vivo evidence for the rolePI3K/Akt/mTOR signalling plays in the control of pluripotency and differentiation, with aparticular focus on the molecular mechanisms underlying these functions.
AU  - Cui,W
AU  - Yu,J
DO  - 10.1242/dev.137075
EP  - 3060
PY  - 2016///
SN  - 0950-1991
SP  - 3050
TI  - Proliferation, survival and metabolism: the role of PI3K/AKT/mTOR signalling in pluripotency and cell fate determination
T2  - Development
UR  - http://dx.doi.org/10.1242/dev.137075
UR  - http://hdl.handle.net/10044/1/38903
VL  - 143
ER  -
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