Imperial College London
Alternate

DrWeiCui

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 2124wei.cui Website

 
 
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Location

 

1010Institute of Reproductive and Developmental BiologyHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Tian:2017:10.7554/eLife.29538.001,
author = {Tian, Y and Ma, X and Lv, C and Sheng, X and Li and Song, Y and Andl, T and Plikus, MV and Sun, J and Ren, F and Shuai, J and Lengner, CJ and Cui, W and Yu, Z},
doi = {10.7554/eLife.29538.001},
journal = {eLife},
pages = {1--30},
title = {Stress responsive miR-31 is a major modulator of mouse intestinal stem cells during regeneration and tumorigenesis},
url = {http://dx.doi.org/10.7554/eLife.29538.001},
volume = {6},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Intestinal regeneration and tumorigenesis are believed to be driven by intestinal stemcells (ISCs). Elucidating mechanisms underlying ISC activation during regeneration andtumorigenesis can help uncover the underlying principles of intestinal homeostasis and diseaseincluding colorectal cancer. Here we show that miR-31 drives ISC proliferation, and protects ISCsagainst apoptosis, both during homeostasis and regeneration in response to ionizing radiationinjury. Furthermore, miR-31 has oncogenic properties, promoting intestinal tumorigenesis.Mechanistically, miR-31 acts to balance input from Wnt, BMP, TGFb signals to coordinate control ofintestinal homeostasis, regeneration and tumorigenesis. We further find that miR-31 is regulated bythe STAT3 signaling pathway in response to radiation injury. These findings identify miR-31 as acritical modulator of ISC biology, and a potential therapeutic target for a broad range of intestinalregenerative disorders and cancers.
AU  - Tian,Y
AU  - Ma,X
AU  - Lv,C
AU  - Sheng,X
AU  - Li
AU  - Song,Y
AU  - Andl,T
AU  - Plikus,MV
AU  - Sun,J
AU  - Ren,F
AU  - Shuai,J
AU  - Lengner,CJ
AU  - Cui,W
AU  - Yu,Z
DO  - 10.7554/eLife.29538.001
EP  - 30
PY  - 2017///
SN  - 2050-084X
SP  - 1
TI  - Stress responsive miR-31 is a major modulator of mouse intestinal stem cells during regeneration and tumorigenesis
T2  - eLife
UR  - http://dx.doi.org/10.7554/eLife.29538.001
UR  - https://elifesciences.org/articles/29538
UR  - http://hdl.handle.net/10044/1/50663
VL  - 6
ER  -
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