Imperial College London
Dr Weihua Zhang

DrWeihuaZhang

Faculty of Medicine, School of Public Health

Honorary Research Associate
 
 
 
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Contact

 

+44 (0)20 7594 1612weihua.zhang

 
 
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Location

 

165Medical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Reeves:2022:10.3389/fpubh.2022.1034227,
author = {Reeves, JJ and Kooner, JS and Zhang, W},
doi = {10.3389/fpubh.2022.1034227},
journal = {Frontiers in Public Health},
pages = {1--12},
title = {Accelerated ageing is associated with increased Covid-19 severity and differences across ethnic groups may exist},
url = {http://dx.doi.org/10.3389/fpubh.2022.1034227},
volume = {10},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background:While increased age is an established risk factor for COVID-19, there is great heterogeneity in outcomes within age groups. This isbecause chronological age does not reflect health, unlike biological age. We intend to investigate the association betweenaccelerated ageing and COVID-19 outcomes through the lens of three measures, namely phenotypic age acceleration(PhenoAgeAccel), telomere length (Adjusted T/S Ratio) and facial ageing, and to examine whether there are differences acrossethnic groups.Methods:Taking participants from the UK Biobank, we associated accelerated ageing with severe COVID-19 outcomes, defined as COVID-related hospitalisation or death. Separate logistic regressions models were created for age and the three accelerated ageing-related variables, adjusting for a variety of covariates in each model. Multivariable logistic regression models were also createdwithin White, Black, Asian and Other ethnic groups to assess for potential differing associations. Forward likelihood ratio logisticregression models were created to evaluate importance of the variables and to assess for patterns of association across the totalpopulation and ethnic groups.Results:After adjusting for all covariates, the odds ratio (OR) and 95% confidence interval (95% CI) of COVID-19 severe outcomes for age was1.080 (1.074-1.086). After further adjusting age for the accelerated ageing variables, the ORs were 1.029 (1.020-1.039) forPhenoAgeAccel and 0.847 (0.772-0.929) for Facial Ageing’s ‘Younger Than You Are’ while Adjusted T/S ratio and ‘Older Than You Are’were statistically insignificant. The OR for age remained similar across ethnic groups. Both PhenoAgeAccel and younger facial agesin the White population and PhenoAgeAccel in the Black population had ORs of 1.031 (1.021-1.042), 0.853 (0.774-0.939), and 1.049(1.001-1.100), respectively. Both Adjusted T/S Ratio and older facial ages showed statistical insignificance in all ethnicities. In
AU  - Reeves,JJ
AU  - Kooner,JS
AU  - Zhang,W
DO  - 10.3389/fpubh.2022.1034227
EP  - 12
PY  - 2022///
SN  - 2296-2565
SP  - 1
TI  - Accelerated ageing is associated with increased Covid-19 severity and differences across ethnic groups may exist
T2  - Frontiers in Public Health
UR  - http://dx.doi.org/10.3389/fpubh.2022.1034227
UR  - https://www.frontiersin.org/articles/10.3389/fpubh.2022.1034227/full
UR  - http://hdl.handle.net/10044/1/100562
VL  - 10
ER  -
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