Imperial College London
Alternate

DrXavierDidelot

Faculty of Medicine, School of Public Health

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 7594 3622x.didelot

 
 
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Location

 

G30Medical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Knight:2020:10.1101/2020.09.21.307223,
author = {Knight, DR and Imwattana, K and Kullin, B and Guerrero-Araya, E and Paredes-Sabja, D and Didelot, X and Dingle, KE and Eyre, DW and Rodríguez, C and Riley, TV},
doi = {10.1101/2020.09.21.307223},
title = {The <i>Clostridioides difficile</i> species problem: global phylogenomic analysis uncovers three ancient, toxigenic, genomospecies},
url = {http://dx.doi.org/10.1101/2020.09.21.307223},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - <jats:title>Abstract</jats:title><jats:p><jats:italic>Clostridioides difficile</jats:italic> infection (CDI) remains an urgent global One Health threat. The genetic heterogeneity seen across <jats:italic>C. difficile</jats:italic> underscores its wide ecological versatility and has driven the significant changes in CDI epidemiology seen in the last 20 years. We analysed an international collection of over 12,000 <jats:italic>C. difficile</jats:italic> genomes spanning the eight currently defined phylogenetic clades. Through whole-genome average nucleotide identity, pangenomic and Bayesian analyses, we identified major taxonomic incoherence with clear species boundaries for each of the recently described cryptic clades CI-III. The emergence of these three novel genomospecies predates clades C1-5 by millions of years, rewriting the global population structure of <jats:italic>C. difficile</jats:italic> specifically and taxonomy of the <jats:italic>Peptostreptococcaceae</jats:italic> in general. These genomospecies all show unique and highly divergent toxin gene architecture, advancing our understanding of the evolution of <jats:italic>C. difficile</jats:italic> and close relatives. Beyond the taxonomic ramifications, this work impacts the diagnosis of CDI worldwide.</jats:p>
AU  - Knight,DR
AU  - Imwattana,K
AU  - Kullin,B
AU  - Guerrero-Araya,E
AU  - Paredes-Sabja,D
AU  - Didelot,X
AU  - Dingle,KE
AU  - Eyre,DW
AU  - Rodríguez,C
AU  - Riley,TV
DO  - 10.1101/2020.09.21.307223
PY  - 2020///
TI  - The <i>Clostridioides difficile</i> species problem: global phylogenomic analysis uncovers three ancient, toxigenic, genomospecies
UR  - http://dx.doi.org/10.1101/2020.09.21.307223
ER  -
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