Imperial College London
Alternate

DrXavierDidelot

Faculty of Medicine, School of Public Health

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 7594 3622x.didelot

 
 
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Location

 

G30Medical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Osnes:2020:10.1101/2020.02.07.935825,
author = {Osnes, MN and Didelot, X and de, Korne-Elenbaas J and Alfsnes, K and Brynildsrud, OB and Syversen, G and Nilsen, Ø and de, Blasio BF and Caugant, DA and Eldholm, V},
doi = {10.1101/2020.02.07.935825},
title = {The sudden emergence of a <i>Neisseria gonorrhoeae</i> strain with reduced susceptibility to extended-spectrum cephalosporins, Norway},
url = {http://dx.doi.org/10.1101/2020.02.07.935825},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - <jats:title>Abstract</jats:title><jats:p>The <jats:italic>Neisseria gonorrhoeae</jats:italic> multilocus sequence type (ST) 7827 emerged in dramatic fashion in Norway in the period 2016-2018. Here, we aim to determine what enabled it to establish and spread so quickly. In Norway, ST-7827 isolates were almost exclusively isolated from men. Phylogeographic analyses demonstrated an Asian origin of the ST with multiple importation events to Europe. The ST was uniformly resistant to fluoroquinolones and associated with reduced susceptibility to both azithromycin and the extended-spectrum cephalosporins (ESC) cefixime and ceftriaxone. We identified additional independent events of acquisition of <jats:italic>penA</jats:italic> and <jats:italic>porB</jats:italic> alleles in Europe, associated with further reduction in cefixime and ceftriaxone susceptibility, respectively. Transmission of the ST was largely curbed in Norway in 2019, but our results indicate the existence of a reservoir in Europe. The worrisome drug resistance profile and rapid emergence of ST-7827 calls for close monitoring of the situation.</jats:p>
AU  - Osnes,MN
AU  - Didelot,X
AU  - de,Korne-Elenbaas J
AU  - Alfsnes,K
AU  - Brynildsrud,OB
AU  - Syversen,G
AU  - Nilsen,Ø
AU  - de,Blasio BF
AU  - Caugant,DA
AU  - Eldholm,V
DO  - 10.1101/2020.02.07.935825
PY  - 2020///
TI  - The sudden emergence of a <i>Neisseria gonorrhoeae</i> strain with reduced susceptibility to extended-spectrum cephalosporins, Norway
UR  - http://dx.doi.org/10.1101/2020.02.07.935825
ER  -
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